6RZ3
 
 | | Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP | | 分子名称: | Cellular tumor antigen p53, RelA-associated inhibitor, ZINC ION | | 著者 | Chen, S, Ren, J, Jones, E.Y, Lu, X. | | 登録日 | 2019-06-12 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | | 主引用文献 | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6XS6
 | | SARS-CoV-2 Spike D614G variant, minus RBD | | 分子名称: | Spike glycoprotein | | 著者 | Wang, X, Egri, S.B, Dudkina, N, Luban, J, Shen, K. | | 登録日 | 2020-07-15 | | 公開日 | 2020-07-22 | | 最終更新日 | 2020-11-11 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Cell, 183, 2020
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7YFM
 | | Structure of GluN1b-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | 分子名称: | Glutamate receptor ionotropic, NMDA 2D, Isoform 6 of Glutamate receptor ionotropic, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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8K3S
 | | Structure of PKD2-F604P complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | 登録日 | 2023-07-16 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
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7YFF
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonist glycine and competitive antagonist CPP. | | 分子名称: | (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFL
 | | Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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7YFO
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7YFR
 | | Structure of GluN1a E698C-GluN2D NMDA receptor in cystines non-crosslinked state. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ... | | 著者 | Zhang, J.L, Zhu, S.J, Zhang, M. | | 登録日 | 2022-07-09 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
Nat.Struct.Mol.Biol., 30, 2023
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6WXL
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6KPF
 | | Cryo-EM structure of a class A GPCR with G protein complex | | 分子名称: | 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Shen, L, Wang, Y.X, Liu, Z.J. | | 登録日 | 2019-08-15 | | 公開日 | 2020-02-12 | | 最終更新日 | 2022-04-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
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6KPG
 | | Cryo-EM structure of CB1-G protein complex | | 分子名称: | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. | | 登録日 | 2019-08-15 | | 公開日 | 2020-02-12 | | 最終更新日 | 2020-03-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
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8XK8
 | | N1D10 Fab bound to SFTSV glycoprotein-Gn | | 分子名称: | Envelopment polyprotein, mAb N1D10 Fab heavy chain, mAb N1D10 Fab light chain | | 著者 | Zhao, H, Deng, Z. | | 登録日 | 2023-12-22 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | | 主引用文献 | A broadly protective antibody targeting the glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.
Nat Commun, 2024
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8XK5
 | | SNB1G11 Fab bound to SFTSV glycoprotein Gn | | 分子名称: | Envelopment polyprotein, mAb SNB1G11 Fab heavy chain, mAb SNB1G11 Fab light chain | | 著者 | Deng, Z. | | 登録日 | 2023-12-22 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | A broadly protective antibody targeting the glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.
Nat Commun, 2024
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8XK6
 | | S2A5 Fab bound to SFTSV glycoprotein Gn | | 分子名称: | Envelopment polyprotein, mAb S2A5 Fab heavy chain, mAb S2A5 Fab light chain | | 著者 | Deng, Z. | | 登録日 | 2023-12-22 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | A broadly protective antibody targeting the glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection.
Nat Commun, 2024
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7KMG
 | | LY-CoV555 neutralizing antibody against SARS-CoV-2 | | 分子名称: | GLYCEROL, LY-CoV555 Fab heavy chain, LY-CoV555 Fab light chain, ... | | 著者 | Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. | | 登録日 | 2020-11-02 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates.
Sci Transl Med, 13, 2021
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3KDU
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3KDT
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8SAI
 | | Cryo-EM structure of GPR34-Gi complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2023-04-01 | | 公開日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7KMH
 | | LY-CoV488 neutralizing antibody against SARS-CoV-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LY-CoV488 Fab heavy chain, ... | | 著者 | Hendle, J, Pustilnik, A, Sauder, J.M, Boyles, J.S, Dickinson, C.D, Coleman, K.A. | | 登録日 | 2020-11-02 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates.
Sci Transl Med, 13, 2021
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7KMI
 | | LY-CoV481 neutralizing antibody against SARS-CoV-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LY-CoV481 Fab heavy chain, ... | | 著者 | Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. | | 登録日 | 2020-11-02 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates.
Sci Transl Med, 13, 2021
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1QT1
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8W6A
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8W6B
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8DWB
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8C3Y
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