8CU4
 
 | | Structure of a K+ selective NaK mutant (NaK2K, Laue diffraction) in the presence of an electric field of ~0.8MV/cm along the crystallographic z axis, 1us, with eightfold extrapolation of structure factor differences | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... | | 著者 | Lee, B, White, K.I, Socolich, M.A, Klureza, M.A, Henning, R, Srajer, V, Ranganathan, R, Hekstra, D. | | 登録日 | 2022-05-16 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Direct visualization of electric field-stimulated ion conduction in a potassium channel
To Be Published
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8CU2
 | | Structure of a K+ selective NaK mutant (NaK2K, Laue diffraction) in the presence of an electric field of ~0.8MV/cm along the crystallographic z axis, 100ns, with eightfold extrapolation of structure factor differences | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... | | 著者 | Lee, B, White, K.I, Socolich, M.A, Klureza, M.A, Henning, R, Srajer, V, Ranganathan, R, Hekstra, D. | | 登録日 | 2022-05-16 | | 公開日 | 2023-07-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Direct visualization of electric field-stimulated ion conduction in a potassium channel
To Be Published
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8Q7W
 | | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 3) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7E
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8PUI
 | | human PHOX2B C-terminal domain including the polyA fragment at 298K | | 分子名称: | Paired mesoderm homeobox protein 2B | | 著者 | Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. | | 登録日 | 2023-07-17 | | 公開日 | 2024-03-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions.
Nat Commun, 15, 2024
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8PTL
 | | human PHOX2B C-terminal domain including the polyA fragment at 278K | | 分子名称: | Paired mesoderm homeobox protein 2B | | 著者 | Anton, R, Trevino, M.A, Pantoja-Uceda, D, Felix, S, Babu, M, Cabrita, E.J, Zweckstetter, M, Tinnefeld, P, Vera, A.M, Oroz, J. | | 登録日 | 2023-07-14 | | 公開日 | 2024-03-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions.
Nat Commun, 15, 2024
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8CRD
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8PIZ
 | | Neisseria meningitidis Type IV pilus SB-DATDH variant bound to the C24 nanobody | | 分子名称: | 2,4-bisacetamido-2,4,6-trideoxy-beta-D-glucopyranose, C24 nanobody, Pilin, ... | | 著者 | Fernandez-Martinez, D, Dumenil, G. | | 登録日 | 2023-06-22 | | 公開日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms.
Nat Commun, 15, 2024
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8Q7V
 | | Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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7AWV
 | | Azoreductase (AzoRo) from Rhodococcus opacus 1CP | | 分子名称: | DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, FMN-dependent NADH-azoreductase, ... | | 著者 | Bento, I, Ngo, A, Qi, J, Juric, C, Tischler, D. | | 登録日 | 2020-11-09 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Identification of molecular basis that underlie enzymatic specificity of AzoRo from Rhodococcus opacus 1CP: A potential NADH:quinone oxidoreductase.
Arch.Biochem.Biophys., 717, 2022
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4BLD
 | | Crystal structure of a human Suppressor of fused (SUFU)-GLI3p complex | | 分子名称: | MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, TRANSCRIPTIONAL ACTIVATOR GLI3, ... | | 著者 | Cherry, A.L, Finta, C, Karlstrom, M, De Sanctis, D, Toftgard, R, Jovine, L. | | 登録日 | 2013-05-02 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.802 Å) | | 主引用文献 | Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
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8CWY
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8C37
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7B85
 | | Crystal Structure of EGFR-WT in Complex with TAK-788 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | | 著者 | Niggenaber, J, Mueller, M.P, Rauh, D. | | 登録日 | 2020-12-12 | | 公開日 | 2022-02-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
J.Med.Chem., 65, 2022
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8C31
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8Q7Q
 | | Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 2) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-16 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7X
 | | Structure of the recycling U5 snRNP bound to chaperone CD2BP2 (State 4) | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Riabov Bassat, D, Plaschka, C, Vorlaender, M.K. | | 登録日 | 2023-08-17 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of human U5 snRNP late biogenesis and recycling.
Nat.Struct.Mol.Biol., 31, 2024
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8Q7H
 | | Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated and neddylated conformation - focused cullin dimer | | 分子名称: | Cullin-9, E3 ubiquitin-protein ligase RBX1, NEDD8, ... | | 著者 | Hopf, L.V.M, Horn-Ghetko, D, Schulman, B.A. | | 登録日 | 2023-08-16 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-07-31 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.
Nat.Struct.Mol.Biol., 31, 2024
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8CPC
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8PM9
 | | Crystal structure of human wild type transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
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7AH9
 | | Substrate-engaged type 3 secretion system needle complex from Salmonella enterica typhimurium - SpaR state 1 | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, LAURYL DIMETHYLAMINE-N-OXIDE, Lipoprotein PrgK, ... | | 著者 | Fahrenkamp, D, Goessweiner-Mohr, N, Miletic, S, Wald, J, Marlovits, T. | | 登録日 | 2020-09-24 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation
Nat Commun, 12, 2021
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8PM8
 | | V30M Transthyretin structure in complex with Tolcalpone | | 分子名称: | Tolcapone, Transthyretin | | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
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8PMO
 | | Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | | 登録日 | 2023-06-29 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
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8PMA
 | | Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | | 登録日 | 2023-06-28 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.
Eur.J.Med.Chem., 261, 2023
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8PW0
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