8WOW
| Crystal structure of Arabidopsis thaliana UDP-glucose 4-epimerase 2 (AtUGE2) complexed with UDP, I160L/G233A mutant | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, UDP-glucose 4-epimerase 2, ... | 著者 | Matsumoto, M, Umezawa, A, Kotake, T, Fushinobu, S. | 登録日 | 2023-10-08 | 公開日 | 2024-05-15 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Cytosolic UDP-L-arabinose synthesis by bifunctional UDP-glucose 4-epimerases in Arabidopsis. Plant J., 119, 2024
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7Q3G
| Pentameric ligand-gated ion channel, DeCLIC at pH 7 with 10 mM Ca2+ | 分子名称: | CALCIUM ION, Neur_chan_LBD domain-containing protein | 著者 | Licksell, M, Rovsnik, U, Hanke, A, Howard, R.J, Lindahl, E. | 登録日 | 2021-10-27 | 公開日 | 2022-11-16 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel. Proc.Natl.Acad.Sci.USA, 119, 2022
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2MD3
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7ZIR
| Cryo-EM structure of hnRNPDL amyloid fibrils | 分子名称: | Heterogeneous nuclear ribonucleoprotein D-like | 著者 | Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S. | 登録日 | 2022-04-08 | 公開日 | 2022-12-28 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun, 14, 2023
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6QAT
| Crystal structure of ULK2 in complexed with hesperadin | 分子名称: | N-{(3Z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1H-indol-5-yl}ethanesulfonamide, Serine/threonine-protein kinase ULK2 | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | 登録日 | 2018-12-19 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem.J., 476, 2019
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4NP1
| NITROPHORIN 1 COMPLEX WITH NITRIC OXIDE | 分子名称: | NITRIC OXIDE, NITROPHORIN 1, PHOSPHATE ION, ... | 著者 | Weichsel, A, Andersen, J.F, Walker, F.A, Montfort, W.R. | 登録日 | 1998-06-26 | 公開日 | 1998-11-11 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Nitric Oxide Binding to the Ferri-and Ferroheme States of Nitrophorin 1, a Reversible No-Binding Heme Protein from the Saliva of the Blood-Sucking Insect, Rhodnius Prolixus To be Published
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7FJH
| LecA from Pseudomonas aeruginosa in complex with 4-Phenylbutyryl hydroxamic acid (CAS: 32153-46-1) | 分子名称: | CALCIUM ION, N-oxidanyl-4-phenyl-butanamide, PA-I galactophilic lectin | 著者 | Shanina, S, Kuhaudomlarp, S, Siebs, E, Fuchsberger, F, Denis, M, da Silva Figueiredo Celstino Gomes, P, Clausen, M.H, Seeberger, P.H, Rognan, D, Titz, A, Imberty, A, Rademacher, C. | 登録日 | 2021-08-04 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Targeting undruggable carbohydrate recognition sites through focused fragment library design. Commun Chem, 5, 2022
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6QIS
| Crystal structure of CAG repeats with synthetic CMBL3a compound (model II) | 分子名称: | CMBL3a, RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), SULFATE ION | 著者 | Kiliszek, A, Blaszczyk, L, Rypniewski, W, Nakatani, K. | 登録日 | 2019-01-21 | 公開日 | 2019-09-25 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019
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7SSJ
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8X0X
| Crystal structure of JE-5C in complex with SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of JE-5C Fab, Light chain of JE-5C Fab, ... | 著者 | Mohapatra, A, Chen, X. | 登録日 | 2023-11-06 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine. Plos Pathog., 20, 2024
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8X0Y
| Crystal structure of JM-1A in complex with SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Heavy chain of JM-1A Fab, ... | 著者 | Mohapatra, A, Chen, X. | 登録日 | 2023-11-06 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine. Plos Pathog., 20, 2024
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3P0P
| Human Tankyrase 2 - Catalytic PARP domain in complex with an inhibitor | 分子名称: | 2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one, SULFATE ION, Tankyrase-2, ... | 著者 | Karlberg, T, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Kotenyova, T, Kouznetsova, E, Moche, M, Nordlund, P, Nyman, T, Persson, C, Schutz, P, Sehic, A, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-09-29 | 公開日 | 2010-10-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nat.Biotechnol., 30, 2012
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3ZDV
| Crystal structure of the LecB lectin from Pseudomonas aeruginosa in complex with Methyl 6-(2,4,6-trimethylphenylsulfonylamido)-6-deoxy-alpha-D-mannopyranoside | 分子名称: | 1,2-ETHANEDIOL, 2,4,6-trimethylbenzenesulfonamide, CALCIUM ION, ... | 著者 | Hauck, D, Joachim, I, Frommeyer, B, Varrot, A, Philipp, B, MOller, H.M, Imberty, A, Exner, T.E, Titz, A. | 登録日 | 2012-11-30 | 公開日 | 2013-09-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas Aeruginosa Lecb with Distinct Binding Modes. Acs Chem.Biol., 8, 2013
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5NOO
| Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | 著者 | Wilk, P, Jarmula, A, Maj, P, Dowiercial, A, Banaszak, K, Rypniewski, W, Rode, W. | 登録日 | 2017-04-12 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS. J. Mol. Graph. Model., 77, 2017
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8WF5
| Horse heart myoglobin reconstituted with an iron complex of porphyrin bearing two CF3 groups (rMb(FePor(CF3)2)) | 分子名称: | GLYCEROL, Myoglobin, PROTOPORPHYRIN(CF3)2 CONTAINING FE, ... | 著者 | Kagawa, Y, Oohora, K, Himiyama, T, Suzuki, A, Hayashi, T. | 登録日 | 2023-09-19 | 公開日 | 2024-06-12 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Redox Engineering of Myoglobin by Cofactor Substitution to Enhance Cyclopropanation Reactivity. Angew.Chem.Int.Ed.Engl., 63, 2024
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6QAU
| Crystal structure of ULK2 in complexed with MRT67307 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | 登録日 | 2018-12-19 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). Biochem.J., 476, 2019
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5NBA
| Complement factor D in complex with the inhibitor (2S,4R)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] | 分子名称: | (2~{S},4~{R})-~{N}1-(1-aminocarbonylindol-3-yl)-4-fluoranyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D | 著者 | Mac Sweeney, A, Ostermann, N. | 登録日 | 2017-03-01 | 公開日 | 2017-06-28 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
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3ZEP
| Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor | 分子名称: | 2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, GLYCEROL, TYROSINE-PROTEIN KINASE JAK3 | 著者 | Kuglstatter, A, Jestel, A, Nagel, S, Boettcher, J, Blaesse, M. | 登録日 | 2012-12-06 | 公開日 | 2013-12-11 | 最終更新日 | 2016-09-14 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery of a Series of Novel 5H-Pyrrolo[2,3-B]Pyrazine-2-Phenyl Ethers, as Potent Jak3 Kinase Inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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1WMR
| Crystal Structure of Isopullulanase from Aspergillus niger ATCC 9642 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Isopullulanase | 著者 | Mizuno, M, Tonozuka, T, Miyasaka, Y, Akeboshi, H, Kamitori, S, Nishikawa, A, Sakano, Y. | 登録日 | 2004-07-15 | 公開日 | 2005-07-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of Aspergillus niger Isopullulanase, a Member of Glycoside Hydrolase Family 49 J.Mol.Biol., 376, 2008
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2ZO6
| Crystal Structure of Kusabira-Cyan (KCY), a Cyan-Emitting GFP-Like Protein | 分子名称: | CYAN-EMITTING GFP-LIKE PROTEIN, KUSABIRA-CYAN (KCY) | 著者 | Kikuchi, A, Fukumura, E, Karasawa, S, Miyawaki, A, Shiro, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2008-05-06 | 公開日 | 2009-05-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of a new cyan fluorescent protein and its hue-shifted variants Biochemistry, 48, 2009
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3ZGH
| Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CELL WALL SURFACE ANCHOR FAMILY PROTEIN, ... | 著者 | Schulte, T, Loefling, J, Mikaelsson, C, Kikhney, A, Hentrich, K, Diamante, A, Ebel, C, Normark, S, Svergun, D, Henriques-Normark, B, Achour, A. | 登録日 | 2012-12-17 | 公開日 | 2014-01-08 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Basic Keratin 10-Binding Domain of the Virulence-Associated Pneumococcal Serine-Rich Protein Psrp Adopts a Novel Mscramm Fold. Open Biol., 4, 2014
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4ZBV
| Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with benzyl T-antigen | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chandran, T, Sharma, A, Vijayan, M. | 登録日 | 2015-04-15 | 公開日 | 2016-03-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure. J.Biosci., 40, 2015
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6Q42
| Crystal Structure of Human Pancreatic Phospholipase A2 | 分子名称: | CHLORIDE ION, Phospholipase A2 | 著者 | Saul, F, Haouz, A, Lambeau, G, Theze, J. | 登録日 | 2018-12-05 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients. J.Clin.Invest., 130, 2020
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3TYR
| Crystal structure of transcriptional regulator VanUg, Form I | 分子名称: | Transcriptional regulator | 著者 | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Dong, A, Depardieu, F, Courvalin, P, Shabalin, I, Chruszcz, M, Minor, W, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-09-26 | 公開日 | 2011-10-12 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Crystal structure of transcriptional regulator VanUg, Form I TO BE PUBLISHED
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3ZGI
| Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP | 分子名称: | 1,2-ETHANEDIOL, CELL WALL SURFACE ANCHOR FAMILY PROTEIN, SULFATE ION | 著者 | Schulte, T, Loefling, J, Mikaelsson, C, Kikhney, A, Hentrich, K, Diamante, A, Ebel, C, Normark, S, Svergun, D, Henriques-Normark, B, Achour, A. | 登録日 | 2012-12-17 | 公開日 | 2013-12-25 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The Basic Keratin 10-Binding Domain of the Virulence-Associated Pneumococcal Serine-Rich Protein Psrp Adopts a Novel Mscramm Fold. Open Biol., 4, 2014
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