6QIS

Crystal structure of CAG repeats with synthetic CMBL3a compound (model II)

Summary for 6QIS

• Entry DOI: 10.2210/pdb6qis/pdb
• Related: 6QIQ 6QIR
• Descriptor: RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), CMBL3a, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cag repeats, cmbl, rna complex with ligand, rna
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 24617.23

Authors

Kiliszek, A.,Blaszczyk, L.,Rypniewski, W.,Nakatani, K. (deposition date: 2019-01-21, release date: 2019-09-25, Last modification date: 2019-11-20)

• Primary citation: Mukherjee, S.,Blaszczyk, L.,Rypniewski, W.,Falschlunger, C.,Micura, R.,Murata, A.,Dohno, C.,Nakatani, K.,Kiliszek, A.; Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.; Nucleic Acids Res., 47:10906-10913, 2019; PubMed: 31566242; DOI: 10.1093/nar/gkz832

Experimental method

X-RAY DIFFRACTION (1.99 Å)