6ZCI
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![BU of 6zci by Molmil](/molmil-images/mine/6zci) | Crystal structure of BRD4-BD1 in complex with NVS-BET-1 | 分子名称: | (4~{R})-4-(4-chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxidanylidene-pyridin-3-yl)-3-methyl-4~{H}-pyrrolo[3,4-c]pyrazol-6-one, Bromodomain-containing protein 4 | 著者 | Faller, M. | 登録日 | 2020-06-11 | 公開日 | 2020-12-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.976 Å) | 主引用文献 | BET bromodomain inhibitors regulate keratinocyte plasticity. Nat.Chem.Biol., 17, 2021
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5D1M
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![BU of 5d1m by Molmil](/molmil-images/mine/5d1m) | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... | 著者 | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | 登録日 | 2015-08-04 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.581 Å) | 主引用文献 | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
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5HJS
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![BU of 5hjs by Molmil](/molmil-images/mine/5hjs) | Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease | 分子名称: | 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, Nuclear receptor coactivator 1, Oxysterols receptor LXR-alpha, ... | 著者 | Parthasarathy, G, Klein, D. | 登録日 | 2016-01-13 | 公開日 | 2016-04-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59, 2016
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5HJP
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![BU of 5hjp by Molmil](/molmil-images/mine/5hjp) | Identification of LXRbeta selective agonists for the treatment of Alzheimer's Disease | 分子名称: | 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, DI(HYDROXYETHYL)ETHER, Oxysterols receptor LXR-beta, ... | 著者 | Parthasarathy, G, Klein, D. | 登録日 | 2016-01-13 | 公開日 | 2016-04-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J.Med.Chem., 59, 2016
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5D1L
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![BU of 5d1l by Molmil](/molmil-images/mine/5d1l) | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) | 分子名称: | DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ... | 著者 | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | 登録日 | 2015-08-04 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.618 Å) | 主引用文献 | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
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4RVZ
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![BU of 4rvz by Molmil](/molmil-images/mine/4rvz) | Crystal structure of tRNA fluorescent labeling enzyme | 分子名称: | MAGNESIUM ION, N-(4-aminobutyl)-2-azidoacetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Dong, J, Li, F, Wang, J, Gong, W. | 登録日 | 2014-11-29 | 公開日 | 2015-03-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A covalent approach for site-specific RNA labeling in Mammalian cells. Angew.Chem.Int.Ed.Engl., 54, 2015
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5HZG
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![BU of 5hzg by Molmil](/molmil-images/mine/5hzg) | The crystal structure of the strigolactone-induced AtD14-D3-ASK1 complex | 分子名称: | (2Z)-2-methylbut-2-ene-1,4-diol, F-box/LRR-repeat MAX2 homolog, SKP1-like protein 1A, ... | 著者 | Yao, R.F, Ming, Z.H, Yan, L.M, Rao, Z.H, Lou, Z.Y, Xie, D.X. | 登録日 | 2016-02-02 | 公開日 | 2016-08-03 | 最終更新日 | 2016-08-31 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | DWARF14 is a non-canonical hormone receptor for strigolactone Nature, 536, 2016
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3LRY
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![BU of 3lry by Molmil](/molmil-images/mine/3lry) | |
8KDM
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![BU of 8kdm by Molmil](/molmil-images/mine/8kdm) | |
8KDR
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![BU of 8kdr by Molmil](/molmil-images/mine/8kdr) | |
8KDS
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![BU of 8kds by Molmil](/molmil-images/mine/8kds) | |
8KDT
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![BU of 8kdt by Molmil](/molmil-images/mine/8kdt) | |
8KEJ
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![BU of 8kej by Molmil](/molmil-images/mine/8kej) | |
8KEK
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![BU of 8kek by Molmil](/molmil-images/mine/8kek) | |
8KEO
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![BU of 8keo by Molmil](/molmil-images/mine/8keo) | |
8KEP
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![BU of 8kep by Molmil](/molmil-images/mine/8kep) | |
8KEQ
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![BU of 8keq by Molmil](/molmil-images/mine/8keq) | |
8KER
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![BU of 8ker by Molmil](/molmil-images/mine/8ker) | |
7KFA
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![BU of 7kfa by Molmil](/molmil-images/mine/7kfa) | PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, ... | 著者 | Chopra, R, Xu, M, Spraggon, G. | 登録日 | 2020-10-13 | 公開日 | 2021-11-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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5Y9F
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7KEV
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![BU of 7kev by Molmil](/molmil-images/mine/7kev) | PCSK9 in complex with a cyclic peptide LDLR disruptor | 分子名称: | CALCIUM ION, Proprotein convertase subtilisin/kexin type 9, Proprotein convertase subtilisin/kexin type 9 Propeptide, ... | 著者 | Spraggon, G, Chopra, R. | 登録日 | 2020-10-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of a PCSK9-LDLR disruptor peptide with in vivo function. Cell Chem Biol, 29, 2022
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5Y9C
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5Y9E
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![BU of 5y9e by Molmil](/molmil-images/mine/5y9e) | Crystal structure of HPV58 pentamer | 分子名称: | GLYCEROL, MAGNESIUM ION, Major capsid protein L1 | 著者 | Li, S.W, Li, Z.H. | 登録日 | 2017-08-24 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.042 Å) | 主引用文献 | Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio, 8, 2017
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8DNT
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![BU of 8dnt by Molmil](/molmil-images/mine/8dnt) | SARS-CoV-2 specific T cell receptor | 分子名称: | Beta-2-microglobulin, MHC class I antigen alpha chain, Nucleoprotein, ... | 著者 | Gallagher, D.T, Wu, D, Gowthaman, R, Pierce, B.G, Mariuzza, R.A, Weng, N.P. | 登録日 | 2022-07-11 | 公開日 | 2023-07-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | SARS-CoV-2 infection establishes a stable and age-independent CD8 + T cell response against a dominant nucleocapsid epitope using restricted T cell receptors. Nat Commun, 14, 2023
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6A0Z
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![BU of 6a0z by Molmil](/molmil-images/mine/6a0z) | Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 13D4, Fab Heavy Chain, ... | 著者 | Li, S, Li, T. | 登録日 | 2018-06-06 | 公開日 | 2018-06-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.329 Å) | 主引用文献 | Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol., 92, 2018
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