7KFA

PCSK9 in complex with PCSK9i a 13mer cyclic peptide LDLR disruptor

Summary for 7KFA

• Entry DOI: 10.2210/pdb7kfa/pdb
• Descriptor: Proprotein convertase subtilisin/kexin type 9 Propeptide, Proprotein convertase subtilisin/kexin type 9, 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, ... (5 entities in total)
• Functional Keywords: pro-protein convertase, coronary heart disease, hypercholesterolemia, low density lipoprotein receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphorylation, protease, secreted, serine protease, steroid metabolism, zymogen, lipid transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 73966.38

Authors

Chopra, R.,Xu, M.,Spraggon, G. (deposition date: 2020-10-13, release date: 2021-11-10, Last modification date: 2023-10-18)

• Primary citation: Brousseau, M.E.,Clairmont, K.B.,Spraggon, G.,Flyer, A.N.,Golosov, A.A.,Grosche, P.,Amin, J.,Andre, J.,Burdick, D.,Caplan, S.,Chen, G.,Chopra, R.,Ames, L.,Dubiel, D.,Fan, L.,Gattlen, R.,Kelly-Sullivan, D.,Koch, A.W.,Lewis, I.,Li, J.,Liu, E.,Lubicka, D.,Marzinzik, A.,Nakajima, K.,Nettleton, D.,Ottl, J.,Pan, M.,Patel, T.,Perry, L.,Pickett, S.,Poirier, J.,Reid, P.C.,Pelle, X.,Seepersaud, M.,Subramanian, V.,Vera, V.,Xu, M.,Yang, L.,Yang, Q.,Yu, J.,Zhu, G.,Monovich, L.G.; Identification of a PCSK9-LDLR disruptor peptide with in vivo function.; Cell Chem Biol, 29:249-, 2022; PubMed: 34547225; DOI: 10.1016/j.chembiol.2021.08.012

Experimental method

X-RAY DIFFRACTION (2.45 Å)