8IAM
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![BU of 8iam by Molmil](/molmil-images/mine/8iam) | Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex | 分子名称: | Chimera of Long chain base biosynthesis protein 1 and Serine palmitoyltransferase 1, N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide, PYRIDOXAL-5'-PHOSPHATE, ... | 著者 | Xie, T, Gong, X. | 登録日 | 2023-02-08 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide. Cell Rep, 43, 2024
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4G2J
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![BU of 4g2j by Molmil](/molmil-images/mine/4g2j) | Human pde9 in complex with selective compound | 分子名称: | 1-cyclopentyl-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Liu, S. | 登録日 | 2012-07-12 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem., 55, 2012
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7WJ4
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7WIZ
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7XMV
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![BU of 7xmv by Molmil](/molmil-images/mine/7xmv) | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A(AMP/ADP) filament bound with ADP, AMP and R5P | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | 登録日 | 2022-04-27 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XN3
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![BU of 7xn3 by Molmil](/molmil-images/mine/7xn3) | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi | 分子名称: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | 登録日 | 2022-04-27 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XMU
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![BU of 7xmu by Molmil](/molmil-images/mine/7xmu) | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | 登録日 | 2022-04-26 | 公開日 | 2022-06-29 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7YK1
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![BU of 7yk1 by Molmil](/molmil-images/mine/7yk1) | Structural basis of human PRPS2 filaments | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Lu, G.M, Hu, H.H, Liu, J.L. | 登録日 | 2022-07-21 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis of human PRPS2 filaments. Cell Biosci, 13, 2023
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7CL0
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![BU of 7cl0 by Molmil](/molmil-images/mine/7cl0) | Crystal structure of human SIRT6 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | Song, K, Zhang, J. | 登録日 | 2020-07-20 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Reply to: Binding site for MDL-801 on SIRT6. Nat.Chem.Biol., 17, 2021
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7CL1
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7CKM
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![BU of 7ckm by Molmil](/molmil-images/mine/7ckm) | Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2020-07-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7CKL
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![BU of 7ckl by Molmil](/molmil-images/mine/7ckl) | Structure of Lassa virus polymerase bound to Z matrix protein | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2020-07-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7ELC
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![BU of 7elc by Molmil](/molmil-images/mine/7elc) | Structure of monomeric complex of MACV L bound to Z and 3'-vRNA | 分子名称: | 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELA
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![BU of 7ela by Molmil](/molmil-images/mine/7ela) | Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) | 分子名称: | 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7EL9
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![BU of 7el9 by Molmil](/molmil-images/mine/7el9) | Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex) | 分子名称: | MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ... | 著者 | Peng, R, Xu, X, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELB
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![BU of 7elb by Molmil](/molmil-images/mine/7elb) | Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Peng, R, Xu, X, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7DPT
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![BU of 7dpt by Molmil](/molmil-images/mine/7dpt) | Structural basis for ligand binding modes of CTP synthase | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | 登録日 | 2020-12-21 | 公開日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DPW
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![BU of 7dpw by Molmil](/molmil-images/mine/7dpw) | Structural basis for ligand binding modes of CTP synthase | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | 登録日 | 2020-12-21 | 公開日 | 2021-09-15 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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