7F04
 
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with Heme and ATP. | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-06-03 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7WB2
 | | Oxidase ChaP-D49L/Y109F mutant | | 分子名称: | ChaP, FE (III) ION | | 著者 | Zong, Y, Zheng, W, Wang, Y, Zhu, J, Tan, R. | | 登録日 | 2021-12-15 | | 公開日 | 2022-05-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7WCC
 | | Oxidase ChaP-D49L/Q91C mutant | | 分子名称: | ChaP, FE (III) ION | | 著者 | Sun, M.X, Zheng, W, Wang, Y.S, Zhu, J.P, Tan, R.X. | | 登録日 | 2021-12-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Oxidase ChaP-D49L/Q91C mutant
To Be Published
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7W5E
 | | Oxidase ChaP D49L mutant | | 分子名称: | ChaP, FE (III) ION | | 著者 | Wang, Y, Zheng, W, Meng, Z, Jin, Y, Zhu, J, Tan, R. | | 登録日 | 2021-11-30 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution.
Angew.Chem.Int.Ed.Engl., 61, 2022
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7VFJ
 | | Cytochrome c-type biogenesis protein CcmABCD | | 分子名称: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | | 著者 | Zhu, J.P, Zhang, K, Li, J, Zheng, W, Gu, M. | | 登録日 | 2021-09-13 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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7VFP
 | | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | | 登録日 | 2021-09-13 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states.
Nat Commun, 13, 2022
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8J1F
 | | GSK101 bound state of mTRPV4 | | 分子名称: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
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8J1H
 | | Agonist1 and Ruthenium Red bound state of mTRPV4 | | 分子名称: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
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8J1D
 | | Cryo-EM structure of apo state mTRPV4 | | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
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8J1B
 | | GSK101 and Ruthenium Red bound state of mTRPV4 | | 分子名称: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-09 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
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8JKM
 | | RN-1747 bound state of mTRPV4 | | 分子名称: | Transient receptor potential cation channel subfamily V member 4 | | 著者 | Zhen, W.X, Yang, F. | | 登録日 | 2023-06-01 | | 公開日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel.
Cell Discov, 9, 2023
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4H12
 | | The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-09-10 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2.
J.Am.Chem.Soc., 134, 2012
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5F1M
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7LF6
 | | Structure of lysosomal membrane protein | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175 | | 著者 | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | | 登録日 | 2021-01-15 | | 公開日 | 2022-01-26 | | 最終更新日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | pH regulates potassium conductance and drives a constitutive proton current in human TMEM175.
Sci Adv, 8, 2022
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4FGY
 | | Identification of a unique PPAR ligand with an unexpected binding mode and antibetic activity | | 分子名称: | (4R,6S,8S,12R,14R,16Z,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9,11-dioxodocos-16-enoic acid, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Wang, R, Li, Y. | | 登録日 | 2012-06-05 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | | 主引用文献 | Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor Gamma (PPAR-gamma) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes.
Diabetologia, 56, 2013
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5IAW
 | | Novel natural FXR modulator with a unique binding mode | | 分子名称: | (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 | | 著者 | Lu, Y, Li, Y. | | 登録日 | 2016-02-22 | | 公開日 | 2017-03-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
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5ICK
 | | A unique binding model of FXR LBD with feroline | | 分子名称: | (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate, Bile acid receptor, Nuclear receptor coactivator 2 | | 著者 | Lu, Y, Li, Y. | | 登録日 | 2016-02-23 | | 公開日 | 2017-03-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
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5H43
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5Z12
 | | A structure of FXR/RXR | | 分子名称: | (9cis)-retinoic acid, 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor, ... | | 著者 | Lu, Y, Li, Y. | | 登録日 | 2017-12-23 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
J. Biol. Chem., 293, 2018
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7VQ1
 | | Structure of Apo-hsTRPM2 channel | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | | 登録日 | 2021-10-18 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel.
Cell Rep, 37, 2021
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7VQ2
 | | Structure of Apo-hsTRPM2 channel TM domain | | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | | 著者 | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | | 登録日 | 2021-10-18 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel.
Cell Rep, 37, 2021
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5EOW
 | | Crystal Structure of 6-Hydroxynicotinic Acid 3-Monooxygenase from Pseudomonas putida KT2440 | | 分子名称: | 6-hydroxynicotinate 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Yuen, M.E, Zhen, W, Gerwig, T.J, Story, R.W, Kopp, M, Nakamoto, K, Snider, M.J, Hicks, K.A. | | 登録日 | 2015-11-10 | | 公開日 | 2016-06-08 | | 最終更新日 | 2016-07-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, A Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation.
Biochemistry, 55, 2016
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7XEM
 | | Cholesterol bound state of mTRPV2 | | 分子名称: | CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2 | | 著者 | Su, N. | | 登録日 | 2022-03-31 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
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7XEO
 | | MbetaCD treated state of mTRPV2 | | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | | 著者 | Su, N. | | 登録日 | 2022-03-31 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
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7XEV
 | | Structure of mTRPV2_2-APB | | 分子名称: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 | | 著者 | Su, N. | | 登録日 | 2022-03-31 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
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