6MW5
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![BU of 6mw5 by Molmil](/molmil-images/mine/6mw5) | UDP-galactose:glucoside-Skp1 alpha-D-galactosyltransferase with bound UDP and Platinum | 分子名称: | 1,2-ETHANEDIOL, PLATINUM (II) ION, UDP-galactose:glucoside-Skp1 alpha-D-galactosyltransferase, ... | 著者 | Kim, H.W, Wood, Z.A, West, C.M. | 登録日 | 2018-10-29 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A terminal alpha 3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii . J.Biol.Chem., 295, 2020
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6MW8
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![BU of 6mw8 by Molmil](/molmil-images/mine/6mw8) | UDP-galactose:glucoside-Skp1 alpha-D-galactosyltransferase with bound UDP and Manganese | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... | 著者 | Kim, H.W, Wood, Z.A, West, C.M. | 登録日 | 2018-10-29 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.756 Å) | 主引用文献 | A terminal alpha 3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii . J.Biol.Chem., 295, 2020
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8DF1
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![BU of 8df1 by Molmil](/molmil-images/mine/8df1) | Chi3l1 bound by antibody C59 | 分子名称: | C59 Fab Heavy chain, C59 Fab Light chain, Chitinase-3-like protein 1, ... | 著者 | Wrapp, D, McLellan, J.S. | 登録日 | 2022-06-21 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice. Antib Ther, 6, 2023
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7LLL
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![BU of 7lll by Molmil](/molmil-images/mine/7lll) | Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | 分子名称: | Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | 登録日 | 2021-02-04 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
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7LLY
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![BU of 7lly by Molmil](/molmil-images/mine/7lly) | Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | 登録日 | 2021-02-04 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
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7JX9
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![BU of 7jx9 by Molmil](/molmil-images/mine/7jx9) | The crystal structure of human ornithine aminotransferase with an intermediate bound during inactivation by (1S,3S)-3-amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic acid. | 分子名称: | (1S,3S,4S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-(1,1,3,3,3-pentafluoroprop-1-en-2-yl)cyclopentane-1-carboxylic acid, N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]glycine, Ornithine aminotransferase, ... | 著者 | Butrin, A, Beaupre, B, Shen, S, Silverman, R.B, Moran, G, Liu, D. | 登録日 | 2020-08-26 | 公開日 | 2021-01-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1 S ,3 S )-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF 3 ). Acs Chem.Biol., 16, 2021
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5XDK
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![BU of 5xdk by Molmil](/molmil-images/mine/5xdk) | Crystal structure of EGFR 696-1022 T790M in complex with CO-1686 | 分子名称: | Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | 著者 | Yan, X.E, Yun, C.H. | 登録日 | 2017-03-28 | 公開日 | 2017-12-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | 主引用文献 | Structural basis of mutant-selectivity and drug-resistance related to CO-1686. Oncotarget, 8, 2017
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5XGN
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![BU of 5xgn by Molmil](/molmil-images/mine/5xgn) | Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976 | 分子名称: | 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, CHLORIDE ION, Epidermal growth factor receptor | 著者 | Kong, L.L, Yun, C.H. | 登録日 | 2017-04-14 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural pharmacological studies on EGFR T790M/C797S. Biochem. Biophys. Res. Commun., 488, 2017
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5XDL
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![BU of 5xdl by Molmil](/molmil-images/mine/5xdl) | |
7EBS
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![BU of 7ebs by Molmil](/molmil-images/mine/7ebs) | Crystal structure of juvenile hormone acid methyltransferase JHAMT from silkworm | 分子名称: | Juvenile hormone acid methyltransferase | 著者 | Guo, P.C, Zhang, Y.S, Zhang, L, Xu, H.Y, Xia, Q.Y. | 登録日 | 2021-03-11 | 公開日 | 2021-09-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem., 297, 2021
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7EBX
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![BU of 7ebx by Molmil](/molmil-images/mine/7ebx) | Crystal structure of juvenile hormone acid methyltransferase JHAMT in complex with S-adenosyl-L-homocysteine. | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, juvenile hormone acid methyltransferase | 著者 | Guo, P.C, Zhang, Y.S, Zhang, L, Xu, H.Y, Xia, Q.Y. | 登録日 | 2021-03-11 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem., 297, 2021
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7EC0
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![BU of 7ec0 by Molmil](/molmil-images/mine/7ec0) | Crystal structure of juvenile hormone acid methyltransferase JHAMT in complex with S-Adenosyl homocysteine and methyl farnesoate | 分子名称: | Juvenile hormone acid methyltransferase, Methyl farnesoate, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Guo, P.C, Zhang, Y.S, Zhang, L, Xu, H.Y, Xia, Q.Y. | 登録日 | 2021-03-11 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | 主引用文献 | Structural basis for juvenile hormone biosynthesis by the juvenile hormone acid methyltransferase. J.Biol.Chem., 297, 2021
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5GNK
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![BU of 5gnk by Molmil](/molmil-images/mine/5gnk) | Crystal structure of EGFR 696-988 T790M in complex with LXX-6-34 | 分子名称: | 1,2-ETHANEDIOL, 1-[(3R)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one, CHLORIDE ION, ... | 著者 | Yan, X.E, Yun, C.H. | 登録日 | 2016-07-21 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. J. Med. Chem., 60, 2017
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8HOR
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![BU of 8hor by Molmil](/molmil-images/mine/8hor) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CH3)-Tyr | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4CH3)-Tyr, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HOS
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![BU of 8hos by Molmil](/molmil-images/mine/8hos) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4NO2)-Tyr | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4NO2)-Tyr, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HOQ
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![BU of 8hoq by Molmil](/molmil-images/mine/8hoq) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Phe(4CF3)-Tyr | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Phe(4CF3)-Tyr, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HOU
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![BU of 8hou by Molmil](/molmil-images/mine/8hou) | Crystal structure of the P450 BM3 heme domain mutant F87A-T268V in complex with Im-N-C4-Phe-Phe | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-N-C4-Phe-Phe, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HOP
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![BU of 8hop by Molmil](/molmil-images/mine/8hop) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Nap-Tyr | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Nap-Tyr, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HON
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![BU of 8hon by Molmil](/molmil-images/mine/8hon) | Crystal structure of the P450 BM3 heme domain mutant F87A in complex with Im-C6-Tyr-Tyr | 分子名称: | Bifunctional cytochrome P450/NADPH--P450 reductase, Im-C6-Tyr-Tyr, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2022-12-10 | 公開日 | 2023-12-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Anchoring a Structurally Editable Proximal Cofactor-like Module to Construct an Artificial Dual-center Peroxygenase. Angew.Chem.Int.Ed.Engl., 62, 2023
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7VEO
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![BU of 7veo by Molmil](/molmil-images/mine/7veo) | Crystal structure of juvenile hormone acid methyltransferase silkworm JHAMT isoform3 complex with S-Adenosyl-L-homocysteine | 分子名称: | Methyltranfer_dom domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Guo, P.C, Zhang, Y.S, Zhang, l, Xu, H.Y. | 登録日 | 2021-09-09 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structural characterization and functional analysis of juvenile hormone acid methyltransferase JHAMT3 from the silkworm, Bombyx mori. Insect Biochem.Mol.Biol., 151, 2022
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7XND
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![BU of 7xnd by Molmil](/molmil-images/mine/7xnd) | |
8K3U
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![BU of 8k3u by Molmil](/molmil-images/mine/8k3u) | S. cerevisiae Chs1 in complex with UDP and GlcNAc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin synthase 1, ... | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-17 | 公開日 | 2023-09-06 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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8K3R
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![BU of 8k3r by Molmil](/molmil-images/mine/8k3r) | S. cerevisiae Chs1 in apo state incubated with GlcNAc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1 | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-16 | 公開日 | 2023-08-16 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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8K3X
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![BU of 8k3x by Molmil](/molmil-images/mine/8k3x) | S. cerevisiae Chs1 in complex with Nikkomycin Z | 分子名称: | (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name), Chitin synthase 1 | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-17 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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8K3W
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![BU of 8k3w by Molmil](/molmil-images/mine/8k3w) | S. cerevisiae Chs1 in complex with UDP-GlcNAc and GlcNAc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Chitin synthase 1, MAGNESIUM ION, ... | 著者 | Bai, L, Chen, D. | 登録日 | 2023-07-17 | 公開日 | 2023-10-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structure, catalysis, chitin transport, and selective inhibition of chitin synthase. Nat Commun, 14, 2023
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