5XDL

Crystal structure of EGFR 696-1022 L858R in complex with CO-1686

Summary for 5XDL

• Entry DOI: 10.2210/pdb5xdl/pdb
• Related: 5XDK
• Descriptor: Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide (3 entities in total)
• Functional Keywords: egfr, l858r, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 38236.03

Authors

Yan, X.E.,Zhu, S.J.,Yun, C.H. (deposition date: 2017-03-28, release date: 2017-12-13, Last modification date: 2023-11-22)

• Primary citation: Yan, X.E.,Zhu, S.J.,Liang, L.,Zhao, P.,Choi, H.G.,Yun, C.H.; Structural basis of mutant-selectivity and drug-resistance related to CO-1686.; Oncotarget, 8:53508-53517, 2017; PubMed: 28881827; DOI: 10.18632/oncotarget.18588

Experimental method

X-RAY DIFFRACTION (2.7 Å)