8K3X

S. cerevisiae Chs1 in complex with Nikkomycin Z

Summary for 8K3X

• Entry DOI: 10.2210/pdb8k3x/pdb
• EMDB information: 36864
• Descriptor: Chitin synthase 1, (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name) (2 entities in total)
• Functional Keywords: antifungal protein-inhibitor complex, antifungal protein/inhibitor
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Total number of polymer chains: 2
• Total formula weight: 260993.16

Authors

Bai, L.,Chen, D. (deposition date: 2023-07-17, release date: 2023-10-18, Last modification date: 2024-05-08)

• Primary citation: Chen, D.D.,Wang, Z.B.,Wang, L.X.,Zhao, P.,Yun, C.H.,Bai, L.; Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.; Nat Commun, 14:4776-4776, 2023; PubMed: 37553334; DOI: 10.1038/s41467-023-40479-4

Experimental method

ELECTRON MICROSCOPY (2.86 Å)