3U85
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3u85 by Molmil](/molmil-images/mine/3u85) | |
3U88
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3u88 by Molmil](/molmil-images/mine/3u88) | Crystal structure of human menin in complex with MLL1 and LEDGF | 分子名称: | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... | 著者 | Huang, J, Wan, B, Lei, M. | 登録日 | 2011-10-16 | 公開日 | 2012-02-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
|
|
3TOJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3toj by Molmil](/molmil-images/mine/3toj) | Structure of the SPRY domain of human Ash2L | 分子名称: | Set1/Ash2 histone methyltransferase complex subunit ASH2 | 著者 | Chen, Y, Cao, F, Wan, B, Dou, Y, Lei, M. | 登録日 | 2011-09-05 | 公開日 | 2012-01-25 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res., 22, 2012
|
|
6VKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vkj by Molmil](/molmil-images/mine/6vkj) | |
6J4F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j4f by Molmil](/molmil-images/mine/6j4f) | Crystal structure of the AtWRKY2 domain | 分子名称: | DNA (5'-D(*AP*GP*CP*CP*TP*TP*TP*GP*AP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*AP*GP*GP*C)-3'), Probable WRKY transcription factor 2, ... | 著者 | Xu, Y.P, Xu, H, Wang, B, Su, X.D. | 登録日 | 2019-01-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the AtWRKY2 domain To Be Published
|
|
6J4G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j4g by Molmil](/molmil-images/mine/6j4g) | Crystal structure of the AtWRKY33 domain | 分子名称: | DNA (5'-D(*AP*GP*CP*CP*TP*TP*TP*GP*AP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*TP*GP*GP*TP*CP*AP*AP*AP*GP*GP*C)-3'), Probable WRKY transcription factor 33, ... | 著者 | Xu, Y.P, Xu, H, Wang, B, Su, X.D. | 登録日 | 2019-01-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structure of the N-terminal DNA binding domain of AtWRKY33 To Be Published
|
|
8C41
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c41 by Molmil](/molmil-images/mine/8c41) | High resolution structure of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*AP*TP*GP*AP*AP*T)-3'), ... | 著者 | Najmudin, S, Pan, X.S, Wang, B, Chayen, N.E, Fisher, L.M, Sanderson, M.R. | 登録日 | 2022-12-30 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin. To Be Published
|
|
4AOJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4aoj by Molmil](/molmil-images/mine/4aoj) | Human TrkA in complex with the inhibitor AZ-23 | 分子名称: | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION | 著者 | Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H. | 登録日 | 2012-03-28 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors Acs Med.Chem.Lett., 3, 2012
|
|
5LQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lqg by Molmil](/molmil-images/mine/5lqg) | |
5LQH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lqh by Molmil](/molmil-images/mine/5lqh) | |
5LIG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lig by Molmil](/molmil-images/mine/5lig) | G-Quadruplex formed at the 5'-end of NHEIII_1 Element in human c-MYC promoter bound to triangulenium based fluorescence probe DAOTA-M2 | 分子名称: | 8,12-bis(2-morpholinoethyl)-8H-benzo[ij]xantheno[1,9,8-cdef][2,7]naphthyridin-12-iumhexafluorophosphate, DNA (5'-D(*TP*AP*GP*GP*GP*AP*GP*GP*GP*TP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3') | 著者 | Kotar, A, Wang, B, Shivalingam, A, Gonzalez-Garcia, J, Vilar, R, Plavec, J. | 登録日 | 2016-07-14 | 公開日 | 2016-09-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex. Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
6OTT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ott by Molmil](/molmil-images/mine/6ott) | Structure of PurF in complex with ppApp | 分子名称: | Amidophosphoribosyltransferase, PurF, MAGNESIUM ION, ... | 著者 | Grant, R.A, Wang, B, Laub, M.T. | 登録日 | 2019-05-03 | 公開日 | 2019-11-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature, 575, 2019
|
|
6SX6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6sx6 by Molmil](/molmil-images/mine/6sx6) | Guanine-rich oligonucleotide with 5'-GC end form G-quadruplex with A(GGGG)A hexad, GCGC- and G-quartets and two symmetric GG and AA base pairs | 分子名称: | GCn | 著者 | Pavc, D, Wang, B, Spindler, L, Drevensek-Olenik, I, Plavec, J, Sket, P. | 登録日 | 2019-09-25 | 公開日 | 2020-07-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | GC ends control topology of DNA G-quadruplexes and their cation-dependent assembly. Nucleic Acids Res., 48, 2020
|
|
7DCN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dcn by Molmil](/molmil-images/mine/7dcn) | |
7DCM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7dcm by Molmil](/molmil-images/mine/7dcm) | Crystal structure of CITX | 分子名称: | Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, ZINC ION | 著者 | Xu, H, Wang, B, Su, X.D. | 登録日 | 2020-10-26 | 公開日 | 2021-11-03 | 最終更新日 | 2023-05-17 | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | 主引用文献 | Co-evolution-based prediction of metal-binding sites in proteomes by machine learning. Nat.Chem.Biol., 19, 2023
|
|
5NSD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5nsd by Molmil](/molmil-images/mine/5nsd) | Co-crystal structure of NAMPT dimer with KPT-9274 | 分子名称: | (~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide, GLYCEROL, Nicotinamide phosphoribosyltransferase, ... | 著者 | Neggers, J.E, Kwanten, B, Dierckx, T, Noguchi, H, Voet, A, Vercruysse, T, Baloglu, E, Senapedis, W, Jacquemyn, M, Daelemans, D. | 登録日 | 2017-04-26 | 公開日 | 2018-02-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.046 Å) | 主引用文献 | Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes. Nat Commun, 9, 2018
|
|
8HB9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hb9 by Molmil](/molmil-images/mine/8hb9) | Crystal Structure of Human IDH1 R132H Mutant in Complex with NADPH and Compound IHMT-IDH1-053 | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | 著者 | Guo, G, Wang, B, Liu, J, Liu, Q. | 登録日 | 2022-10-27 | 公開日 | 2023-05-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor. Eur.J.Med.Chem., 256, 2023
|
|
6SYK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6syk by Molmil](/molmil-images/mine/6syk) | Guanine-rich oligonucleotide with 5'- and 3'-GC ends form G-quadruplex with A(GGGG)A hexad, GCGC- and G-quartets and two symmetric GG and AA base pair | 分子名称: | GCnCG | 著者 | Pavc, D, Wang, B, Spindler, L, Drevensek-Olenik, I, Plavec, J, Sket, P. | 登録日 | 2019-09-30 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | GC ends control topology of DNA G-quadruplexes and their cation-dependent assembly. Nucleic Acids Res., 48, 2020
|
|
5EPO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5epo by Molmil](/molmil-images/mine/5epo) | The three-dimensional structure of Clostridium absonum 7alpha-hydroxysteroid dehydrogenase | 分子名称: | 7-alpha-hydroxysteroid deydrogenase, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Lou, D, Wang, B, Wang, F. | 登録日 | 2015-11-12 | 公開日 | 2016-03-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The three-dimensional structure of Clostridium absonum 7 alpha-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition Sci Rep, 6, 2016
|
|
3ID4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3id4 by Molmil](/molmil-images/mine/3id4) | Crystal Structure of RseP PDZ2 domain fused GKASPV peptide | 分子名称: | Regulator of sigma E protease | 著者 | Li, X, Wang, B, Feng, L, Wang, J, Shi, Y. | 登録日 | 2009-07-20 | 公開日 | 2009-08-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3ID2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3id2 by Molmil](/molmil-images/mine/3id2) | Crystal Structure of RseP PDZ2 domain | 分子名称: | IODIDE ION, Regulator of sigma E protease | 著者 | Li, X, Wang, B, Feng, L, Wang, J, Shi, Y. | 登録日 | 2009-07-20 | 公開日 | 2009-08-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.089 Å) | 主引用文献 | Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3ID1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3id1 by Molmil](/molmil-images/mine/3id1) | Crystal Structure of RseP PDZ1 domain | 分子名称: | Regulator of sigma E protease | 著者 | Li, X, Wang, B, Feng, L, Wang, J, Shi, Y. | 登録日 | 2009-07-20 | 公開日 | 2009-08-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3ID3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3id3 by Molmil](/molmil-images/mine/3id3) | Crystal Structure of RseP PDZ2 I304A domain | 分子名称: | Regulator of sigma E protease | 著者 | Li, X, Wang, B, Feng, L, Wang, J, Shi, Y. | 登録日 | 2009-07-20 | 公開日 | 2009-08-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
1A37
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1a37 by Molmil](/molmil-images/mine/1a37) | 14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE | 分子名称: | 14-3-3 PROTEIN ZETA, PS-RAF259 PEPTIDE LSQRQRST(SEP)TPNVHM | 著者 | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | 登録日 | 1998-01-28 | 公開日 | 1999-03-02 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
|
|
1A38
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1a38 by Molmil](/molmil-images/mine/1a38) | 14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE | 分子名称: | 14-3-3 PROTEIN ZETA, R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) | 著者 | Petosa, C, Masters, S.C, Pohl, J, Wang, B, Fu, H, Liddington, R.C. | 登録日 | 1998-01-28 | 公開日 | 1999-03-02 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | 主引用文献 | 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J.Biol.Chem., 273, 1998
|
|