5NSD

Co-crystal structure of NAMPT dimer with KPT-9274

Summary for 5NSD

Entry DOI	10.2210/pdb5nsd/pdb
Descriptor	Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	drug target, nampt, crispr/cas, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P43490
Total number of polymer chains	2
Total formula weight	115480.08
Authors	Neggers, J.E.,Kwanten, B.,Dierckx, T.,Noguchi, H.,Voet, A.,Vercruysse, T.,Baloglu, E.,Senapedis, W.,Jacquemyn, M.,Daelemans, D. (deposition date: 2017-04-26, release date: 2018-02-14, Last modification date: 2018-03-07)
Primary citation	Neggers, J.E.,Kwanten, B.,Dierckx, T.,Noguchi, H.,Voet, A.,Bral, L.,Minner, K.,Massant, B.,Kint, N.,Delforge, M.,Vercruysse, T.,Baloglu, E.,Senapedis, W.,Jacquemyn, M.,Daelemans, D. Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes. Nat Commun, 9:502-502, 2018 Cited by PubMed: 29402884 DOI: 10.1038/s41467-017-02349-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.046 Å)

Structure validation