5NSD
Co-crystal structure of NAMPT dimer with KPT-9274
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Nicotinamide phosphoribosyltransferase | polymer | 497 | 56389.8 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 14 | Chemie (GOL) | |||
| 4 | A, B | (~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide | non-polymer | 610.6 | 2 | Chemie (96Q) | |||
| 5 | water | water | 18.0 | 809 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Glu 492 | - | expression tag |
| Asn 493 | - | expression tag |
| Leu 494 | - | expression tag |
| Tyr 495 | - | expression tag |
| Phe 496 | - | expression tag |
| Gln 497 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112779.6 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2700.5 | |
| All* | Total formula weight | 115480.1 |
