5NSD
Co-crystal structure of NAMPT dimer with KPT-9274
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007165 | biological_process | signal transduction |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0009435 | biological_process | NAD biosynthetic process |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0030054 | cellular_component | cell junction |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0034356 | biological_process | NAD biosynthesis via nicotinamide riboside salvage pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| A | 0048511 | biological_process | rhythmic process |
| A | 0051770 | biological_process | positive regulation of nitric-oxide synthase biosynthetic process |
| A | 0060612 | biological_process | adipose tissue development |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007165 | biological_process | signal transduction |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0009435 | biological_process | NAD biosynthetic process |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0030054 | cellular_component | cell junction |
| B | 0032922 | biological_process | circadian regulation of gene expression |
| B | 0034356 | biological_process | NAD biosynthesis via nicotinamide riboside salvage pathway |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| B | 0048511 | biological_process | rhythmic process |
| B | 0051770 | biological_process | positive regulation of nitric-oxide synthase biosynthetic process |
| B | 0060612 | biological_process | adipose tissue development |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | ARG392 |
| A | SER398 |
| A | LYS400 |
| A | HOH611 |
| A | HOH615 |
| A | HOH828 |
| B | GOL502 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ASP354 |
| B | LYS423 |
| B | PO4501 |
| B | HOH635 |
| A | ASP313 |
| A | GLY353 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | PHE123 |
| A | VAL124 |
| A | ARG434 |
| A | ASN479 |
| A | HOH617 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | VAL300 |
| A | HOH610 |
| A | HOH633 |
| B | ASP184 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ASN396 |
| A | ASP420 |
| A | HOH707 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | LEU13 |
| A | ALA14 |
| A | HOH654 |
| B | TYR195 |
| B | GLN201 |
| B | ALA222 |
| B | HOH654 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | TYR54 |
| A | GLY385 |
| A | LYS389 |
| A | LEU390 |
| A | HOH766 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | TYR64 |
| A | LYS68 |
| A | LEU226 |
| A | TYR230 |
| A | HOH626 |
| A | HOH808 |
| A | HOH831 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 509 |
| Chain | Residue |
| A | TYR240 |
| A | SER241 |
| A | VAL242 |
| B | HIS90 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 510 |
| Chain | Residue |
| A | GLU187 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue 96Q A 511 |
| Chain | Residue |
| A | TYR188 |
| A | HIS191 |
| A | PHE193 |
| A | ARG196 |
| A | LYS216 |
| A | GLY217 |
| A | ASP219 |
| A | TYR240 |
| A | VAL242 |
| A | ALA244 |
| A | SER275 |
| A | ARG311 |
| A | ARG349 |
| A | ALA379 |
| A | HOH697 |
| A | HOH751 |
| A | HOH765 |
| A | HOH842 |
| B | TYR18 |
| B | GLN92 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| A | GOL502 |
| B | ARG40 |
| B | ARG392 |
| B | SER398 |
| B | LYS400 |
| B | HOH629 |
| B | HOH634 |
| B | HOH635 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| A | LYS423 |
| A | PO4501 |
| B | ASP313 |
| B | GLY353 |
| B | ASP354 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | GLN63 |
| B | TYR230 |
| B | TYR231 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | TYR471 |
| B | GLU475 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | PHE123 |
| B | VAL124 |
| B | ARG434 |
| B | PHE440 |
| B | ASN479 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | ARG477 |
| B | HOH620 |
| B | HOH702 |
| B | LYS169 |
| B | GLU187 |
| B | LEU212 |
| B | VAL213 |
| B | ASN214 |
| B | PHE215 |
| B | LYS216 |
| site_id | AD9 |
| Number of Residues | 18 |
| Details | binding site for residue 96Q B 507 |
| Chain | Residue |
| A | TYR18 |
| A | GLN92 |
| A | HOH760 |
| B | TYR188 |
| B | HIS191 |
| B | PHE193 |
| B | ARG196 |
| B | LYS216 |
| B | ASP219 |
| B | TYR240 |
| B | VAL242 |
| B | ALA244 |
| B | SER275 |
| B | ARG311 |
| B | ARG349 |
| B | HOH715 |
| B | HOH734 |
| B | HOH999 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG392 | |
| B | ARG196 | |
| B | ASP219 | |
| B | HIS247 | |
| B | ARG311 | |
| B | GLY353 | |
| B | GLY384 | |
| B | ARG392 | |
| A | ARG196 | |
| A | ASP219 | |
| A | HIS247 | |
| A | ARG311 | |
| A | GLY353 | |
| A | GLY384 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| B | MET1 | |
| A | MET1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR188 | |
| B | TYR188 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER472 | |
| B | SER472 |
