8C41

High resolution structure of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin

Summary for 8C41

• Entry DOI: 10.2210/pdb8c41/pdb
• Descriptor: Fused ParE30ParC55 CLEAVAGE COMPLEX of the TOPOISOMERASE IV, DNA (5'-D(*CP*AP*TP*GP*AP*AP*T)-3'), DNA (5'-D(P*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*G)-3'), ... (10 entities in total)
• Functional Keywords: protein-dna cleavage complex, topoisomerase iia, delafloxacin, topoisomerase iv-dna-antibiotic complex, isomerase
• Biological source: Streptococcus pneumoniae; More
• Total number of polymer chains: 6
• Total formula weight: 180816.89

Authors

Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2022-12-30, release date: 2024-01-10, Last modification date: 2024-01-24)

• Primary citation: Najmudin, S.,Pan, X.S.,Wang, B.,Chayen, N.E.,Fisher, L.M.,Sanderson, M.R.; The nature of the molecular interactions at high resolution of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.393 Å)