8C41
High resolution structure of the Streptococcus pneumoniae topoisomerase IV-DNA complex with the novel fluoroquinolone Delafloxacin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fused ParE30ParC55 CLEAVAGE COMPLEX of the TOPOISOMERASE IV | polymer | 742 | 84211.4 | 2 | Pfam (PF00521) UniProt (by SIFTS) (P72525) | Streptococcus pneumoniae | |
| 2 | C (E) | DNA (5'-D(*CP*AP*TP*GP*AP*AP*T)-3') | polymer | 7 | 2121.4 | 1 | DNA molecule | ||
| 3 | D (F) | DNA (5'-D(P*AP*GP*TP*CP*AP*TP*TP*CP*AP*TP*G)-3') | polymer | 11 | 3348.2 | 1 | DNA molecule | ||
| 4 | E (G) | DNA (5'-D(*CP*GP*TP*GP*CP*AP*T)-3') | polymer | 7 | 2113.4 | 1 | DNA molecule | ||
| 5 | F (H) | DNA (5'-D(P*GP*AP*CP*TP*AP*TP*GP*CP*AP*CP*G)-3') | polymer | 11 | 3358.2 | 1 | DNA molecule | ||
| 6 | G, H, M (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 3 | Chemie (MPD) | |||
| 7 | I, J, K, N, O... (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 8 | L, Q (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 9 | R, S (F, H) | delafloxacin | non-polymer | 440.8 | 2 | Chemie (TE9) | |||
| 10 | T, U, V, W, X... (A, B, E, F, G...) | water | water | 18.0 | 418 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 179364.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1452.8 | |
| All* | Total formula weight | 180816.9 |
