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7OQM
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BU of 7oqm by Molmil
Human OMPD-domain of UMPS in complex with substrate OMP at 1.05 Angstroms resolution, 20 minutes soaking
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-03
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OQN
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BU of 7oqn by Molmil
Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 30 minutes soaking
分子名称: GLYCEROL, SULFATE ION, URIDINE-5'-MONOPHOSPHATE, ...
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-03
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OQF
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BU of 7oqf by Molmil
Human OMPD-domain of UMPS in complex with OMP at 1.05 Angstrom resolution, 5 minutes soaking
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-03
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OQI
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BU of 7oqi by Molmil
Human OMPD-domain of UMPS in complex with substrate OMP at 1.15 Angstrom resolution, 10 minutes soaking
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-03
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OQK
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BU of 7oqk by Molmil
Human OMPD-domain of UMPS in complex with substrate OMP at 1.10 Angstroms resolution, 15 minutes soaking
分子名称: GLYCEROL, OROTIDINE-5'-MONOPHOSPHATE, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-03
公開日2022-04-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OUZ
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BU of 7ouz by Molmil
Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.9 Angstroms resolution, crystal 1
分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, PROLINE, ...
著者Rindfleisch, S, Tittmann, K.
登録日2021-06-14
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OV0
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BU of 7ov0 by Molmil
Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in resting state at 0.95 Angstrom resolution
分子名称: GLYCEROL, PROLINE, SULFATE ION, ...
著者Rindfleisch, S, Rabe von Pappenheim, F.
登録日2021-06-14
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7OTU
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BU of 7otu by Molmil
Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2
分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Isoform 2 of Uridine 5'-monophosphate synthase
著者Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K.
登録日2021-06-10
公開日2022-04-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
7Q1H
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BU of 7q1h by Molmil
Variant D312N of Orotidine 5'-monophosphate decarboxylase-domain of human UMPS in complex with the substrate OMP at 1.31 Angstrom resolution
分子名称: OROTIDINE-5'-MONOPHOSPHATE, PROLINE, SULFATE ION, ...
著者Rabe von Pappenheim, F, Kirck, L.L.
登録日2021-10-20
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis
Nat Catal, 5, 2022
5DMI
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BU of 5dmi by Molmil
Structure of the extracellular domain of the CD40 in complex with CHI220 FAB
分子名称: Chi220 Fab heavy chain, Chi220 Fab light chain, SULFATE ION, ...
著者Sheriff, S.
登録日2015-09-08
公開日2016-06-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.69 Å)
主引用文献Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
4O1X
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BU of 4o1x by Molmil
Crystal structure of human thymidylate synthase double mutant C195S-Y202C
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者Pozzi, C, Mangani, S.
登録日2013-12-16
公開日2015-01-21
最終更新日2023-03-01
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Elife, 11, 2022
6H9B
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BU of 6h9b by Molmil
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation
分子名称: 9-methyl-3-[1-(2-methylquinolin-4-yl)ethenyl]carbazole, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Varela, P.F, Gigant, B.
登録日2018-08-03
公開日2018-12-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
J. Med. Chem., 62, 2019
6V13
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BU of 6v13 by Molmil
immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, G08 TCR alpha chain, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-19
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
6V0Y
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BU of 6v0y by Molmil
immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 72,74cit69-81, GLYCEROL, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-19
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
6V65
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BU of 6v65 by Molmil
Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
分子名称: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
著者Yan, W, Simanshu, D.K.
登録日2019-12-04
公開日2020-07-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.763 Å)
主引用文献Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
6V15
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BU of 6v15 by Molmil
immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 72,74cit69-81, G08 TCR alpha chain, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-19
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
6UPS
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BU of 6ups by Molmil
Crystal structure of the deubiquitylase domain from the Orientia tsutsugamushi protein OTT_1962 (OtDUB)
分子名称: ULP_PROTEASE domain-containing protein
著者Ronau, J.A, Lim, C.S, Xiong, Y.
登録日2019-10-18
公開日2020-04-01
最終更新日2021-04-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi.
Nat Commun, 11, 2020
6UPU
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BU of 6upu by Molmil
Crystal structure of the Orientia tsutsugamushi OtDUB in complex with three molecules of ubiquitin
分子名称: ULP_PROTEASE domain-containing protein, Ubiquitin
著者Lim, C.S, Ronau, J.A, Xiong, Y.
登録日2019-10-18
公開日2020-04-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi.
Nat Commun, 11, 2020
6V19
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BU of 6v19 by Molmil
immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 72,74cit69-81, GLYCEROL, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-20
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021
4O1U
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BU of 4o1u by Molmil
Crystal structure of human thymidylate synthase mutant Y202C
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
著者Pozzi, C, Mangani, S.
登録日2013-12-16
公開日2015-01-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.
Elife, 11, 2022
6V6F
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BU of 6v6f by Molmil
Crystal structure of Q61L KRAS(GMPPNP)-NF1(GRD)-SPRED1(EVH1) complex
分子名称: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
著者Yan, W, Simanshu, D.K.
登録日2019-12-05
公開日2020-07-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.542 Å)
主引用文献Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
6VDG
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BU of 6vdg by Molmil
Crystal Structure of the Y182A HisF Mutant from Thermotoga maritima
分子名称: Imidazole glycerol phosphate synthase subunit HisF, PHOSPHATE ION
著者Almeida, V.M, Matsuyama, B.Y, Farah, C.S, Marana, S.R.
登録日2019-12-27
公開日2020-01-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Role of a high centrality residue in protein dynamics and thermal stability.
J.Struct.Biol., 213, 2021
7LC2
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BU of 7lc2 by Molmil
Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1
分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Dharmaiah, S, Simanshu, D.K.
登録日2021-01-09
公開日2021-07-28
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LC1
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BU of 7lc1 by Molmil
Crystal Structure of KRAS4b (GMPPNP-bound) in complex with the RBD-PH domains of SIN1
分子名称: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Dharmaiah, S, Simanshu, D.K.
登録日2021-01-09
公開日2021-08-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
Proc.Natl.Acad.Sci.USA, 118, 2021
6V1A
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BU of 6v1a by Molmil
immune receptor complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen beta 74cit69-81, GLYCEROL, ...
著者Lim, J.J, Rossjohn, J.
登録日2019-11-20
公開日2020-11-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Sci Immunol, 6, 2021

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