6GZS
 
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9EIH
 | | Import stalled PINK1 TOM complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM20 homolog, Mitochondrial import receptor subunit TOM22 homolog, ... | | 著者 | Kirk, N.S, Glukhova, A, Callegari, S, Komander, D. | | 登録日 | 2024-11-26 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of human PINK1 at a mitochondrial TOM-VDAC array.
Science, 388, 2025
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9EII
 | | Import stalled PINK1 TOM complex, symmetry expanded | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM20 homolog, Mitochondrial import receptor subunit TOM22 homolog, ... | | 著者 | Kirk, N.S, Glukhova, A, Callegari, S, Komander, D. | | 登録日 | 2024-11-26 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Structure of human PINK1 at a mitochondrial TOM-VDAC array.
Science, 388, 2025
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5LJM
 | | Structure of SPATA2 PUB domain | | 分子名称: | GLYCEROL, Spermatogenesis-associated protein 2 | | 著者 | Elliott, P.R, Komander, D. | | 登録日 | 2016-07-18 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.454 Å) | | 主引用文献 | SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.
Mol.Cell, 63, 2016
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9EIJ
 | | Import stalled PINK1 TOM complex, extended TOM20 helix class | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM20 homolog, Mitochondrial import receptor subunit TOM22 homolog, ... | | 著者 | Kirk, N.S, Glukhova, A, Callegari, S, Komander, D. | | 登録日 | 2024-11-26 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of human PINK1 at a mitochondrial TOM-VDAC array.
Science, 388, 2025
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5LJN
 | | Structure of the HOIP PUB domain bound to SPATA2 PIM peptide | | 分子名称: | E3 ubiquitin-protein ligase RNF31, GLYCEROL, SULFATE ION, ... | | 著者 | Elliott, P.R, Komander, D. | | 登録日 | 2016-07-18 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.
Mol.Cell, 63, 2016
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6HEM
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6HEK
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6HEJ
 | | Structure of human USP28 | | 分子名称: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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6I9C
 | | Structure of the OTU domain of OTULIN G281R mutant | | 分子名称: | CHLORIDE ION, GLYCEROL, Ubiquitin thioesterase otulin | | 著者 | Damgaard, R.B, Elliott, P.R, Swatek, K.N, Maher, E.R, Stepensky, P, Elpeleg, O, Komander, D, Berkun, Y. | | 登録日 | 2018-11-22 | | 公開日 | 2019-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.
Embo Mol Med, 11, 2019
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6HEH
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6HEI
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6HEL
 | | Structure of human USP25 | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 25 | | 著者 | Gersch, M, Komander, D. | | 登録日 | 2018-08-20 | | 公開日 | 2019-03-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.941 Å) | | 主引用文献 | Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
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5AAZ
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | 分子名称: | OPTINEURIN, ZINC ION | | 著者 | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | 登録日 | 2015-07-31 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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5AAQ
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | 分子名称: | CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2, ZINC ION | | 著者 | Thurston, T.L, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | 登録日 | 2015-07-28 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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5AAY
 | | TBK1 recruitment to cytosol-invading Salmonella induces anti- bacterial autophagy | | 分子名称: | NF-KAPPA-B ESSENTIAL MODULATOR, ZINC ION | | 著者 | Thurston, T.l, Allen, M.D, Ravenhill, B, Karpiyevitch, M, Bloor, S, Kaul, A, Matthews, S, Komander, D, Holden, D, Bycroft, M, Randow, F. | | 登録日 | 2015-07-31 | | 公開日 | 2016-07-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recruitment of Tbk1 to Cytosol-Invading Salmonella Induces Wipi2-Dependent Antibacterial Autophagy.
Embo J., 35, 2016
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2WX0
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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2WX1
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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2XEW
 | | Crystal structure of K11-linked diubiquitin | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, CITRATE ANION, ... | | 著者 | Bremm, A, Freund, S.M.V, Komander, D. | | 登録日 | 2010-05-18 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Lys11-Linked Ubiquitin Chains Adopt Compact Conformations and are Preferentially Hydrolyzed by the Deubiquitinase Cezanne
Nat.Struct.Mol.Biol., 17, 2010
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5LRU
 | | Structure of Cezanne/OTUD7B OTU domain | | 分子名称: | OTU domain-containing protein 7B | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5LRX
 | | Structure of A20 OTU domain bound to ubiquitin | | 分子名称: | Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3 | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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2XK5
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5LRV
 | | Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin | | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ... | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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5LRW
 | | Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin | | 分子名称: | GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B | | 著者 | Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D. | | 登録日 | 2016-08-22 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
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2WWZ
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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