1SVR
 
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1TLE
 | | LE (LAMININ-TYPE EGF-LIKE) MODULE GIII4 IN SOLUTION AT PH 3.5 AND 290 K, NMR, 14 STRUCTURES | | 分子名称: | LAMININ | | 著者 | Baumgartner, R, Czisch, M, Mayer, U, Schl, E.P, Huber, R, Timpl, R, Holak, T.A. | | 登録日 | 1996-01-26 | | 公開日 | 1997-02-12 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the nidogen binding LE module of the laminin gamma1 chain in solution.
J.Mol.Biol., 257, 1996
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1OXD
 | | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | | 分子名称: | cyan fluorescent protein cfp | | 著者 | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | | 登録日 | 2003-04-02 | | 公開日 | 2003-12-02 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins
J.Mol.Biol., 328, 2003
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1OXE
 | | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | | 分子名称: | cyan fluorescent protein cfp | | 著者 | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | | 登録日 | 2003-04-02 | | 公開日 | 2003-12-02 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins
J.Mol.Biol., 328, 2003
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1OH1
 | | Solution structure of staphostatin A form Staphylococcus aureus confirms the discovery of a novel class of cysteine proteinase inhibitors. | | 分子名称: | STAPHOSTATIN A | | 著者 | Dubin, G, Popowicz, G, Krajewski, M, Stec, J, Bochtler, M, Potempa, J, Dubin, A, Holak, T.A. | | 登録日 | 2003-05-21 | | 公開日 | 2003-11-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Novel Class of Cysteine Protease Inhibitors: Solution Structure of Staphostatin a from Staphylococcus Aureus
Biochemistry, 42, 2003
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1QLO
 | | Structure of the active domain of the herpes simplex virus protein ICP47 in water/sodium dodecyl sulfate solution determined by nuclear magnetic resonance spectroscopy | | 分子名称: | HERPES SIMPLEX VIRUS PROTEIN ICP47 | | 著者 | Pfaender, R, Neumann, L, Zweckstetter, M, Seger, C, Holak, T.A, Tampe, R. | | 登録日 | 1999-09-09 | | 公開日 | 1999-12-14 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Structure of the Active Domain of the Herpes Simplex Virus Protein Icp47 in Water/Sodium Dodecyl Sulfate Solution Determined by Nuclear Magnetic Resonance Spectroscopy.
Biochemistry, 38, 1999
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1NMG
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1NMF
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1NPS
 | | CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF PROTEIN S | | 分子名称: | CALCIUM ION, DEVELOPMENT-SPECIFIC PROTEIN S | | 著者 | Wenk, M, Baumgartner, R, Mayer, E.M, Huber, R, Holak, T.A, Jaenicke, R. | | 登録日 | 1999-02-01 | | 公開日 | 2000-02-04 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The domains of protein S from Myxococcus xanthus: structure, stability and interactions.
J.Mol.Biol., 286, 1999
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1OXF
 | | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins | | 分子名称: | cyan fluorescent protein cfp | | 著者 | Hyun Bae, J, Rubini, M, Jung, G, Wiegand, G, Seifert, M.H, Azim, M.K, Kim, J.S, Zumbusch, A, Holak, T.A, Moroder, L, Huber, R, Budisa, N. | | 登録日 | 2003-04-02 | | 公開日 | 2003-12-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Expansion of the Genetic Code Enables Design of a Novel "Gold" Class of Green Fluorescent Proteins
J.Mol.Biol., 328, 2003
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1A23
 | | SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | DSBA | | 著者 | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | | 登録日 | 1998-01-15 | | 公開日 | 1998-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of reduced DsbA from Escherichia coli in solution.
Biochemistry, 37, 1998
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1A24
 | | SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, FAMILY OF 20 STRUCTURES | | 分子名称: | DSBA | | 著者 | Schirra, H.J, Renner, C, Czisch, M, Huber-Wunderlich, M, Holak, T.A, Glockshuber, R. | | 登録日 | 1998-01-15 | | 公開日 | 1998-09-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of reduced DsbA from Escherichia coli in solution.
Biochemistry, 37, 1998
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1AG4
 | | NMR STRUCTURE OF SPHERULIN 3A (S3A) FROM PHYSARUM POLYCEPHALUM, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | SPHERULIN 3A | | 著者 | Rosinke, B, Renner, C, Mayr, E.-M, Jaenicke, R, Holak, T.A. | | 登録日 | 1997-04-01 | | 公開日 | 1998-04-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ca2+-loaded spherulin 3a from Physarum polycephalum adopts the prototype gamma-crystallin fold in aqueous solution.
J.Mol.Biol., 271, 1997
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1DTV
 | | NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI) | | 分子名称: | CARBOXYPEPTIDASE INHIBITOR | | 著者 | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | | 登録日 | 2000-01-13 | | 公開日 | 2000-07-19 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
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1DTD
 | | CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2) | | 分子名称: | CARBOXYPEPTIDASE A2, GLUTAMIC ACID, METALLOCARBOXYPEPTIDASE INHIBITOR, ... | | 著者 | Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X. | | 登録日 | 2000-01-12 | | 公開日 | 2000-07-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
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1BD8
 | | STRUCTURE OF CDK INHIBITOR P19INK4D | | 分子名称: | P19INK4D CDK4/6 INHIBITOR | | 著者 | Baumgartner, R, Fernandez-Catalan, C, Winoto, A, Huber, R, Engh, R, Holak, T.A. | | 登録日 | 1998-05-12 | | 公開日 | 1998-10-14 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a.
Structure, 6, 1998
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1DNY
 | | SOLUTION STRUCTURE OF PCP, A PROTOTYPE FOR THE PEPTIDYL CARRIER DOMAINS OF MODULAR PEPTIDE SYNTHETASES | | 分子名称: | NON-RIBOSOMAL PEPTIDE SYNTHETASE PEPTIDYL CARRIER PROTEIN | | 著者 | Weber, T, Baumgartner, R, Renner, C, Marahiel, M.A, Holak, T.A. | | 登録日 | 1999-12-17 | | 公開日 | 2000-05-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases.
Structure Fold.Des., 8, 2000
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7BEA
 | | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor | | 分子名称: | 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine, Programmed cell death 1 ligand 1 | | 著者 | Magiera-Mularz, K, Butera, R, Wazynska, M, Holak, T, Domling, A. | | 登録日 | 2020-12-22 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
Acs Med.Chem.Lett., 12, 2021
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7OUN
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6R8G
 | | Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine | | 分子名称: | 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | | 登録日 | 2019-04-01 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity
Commun Biol, 2021
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8ALX
 | | Structure of human PD-L1 in complex with inhibitor | | 分子名称: | 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, AMINOMETHYLAMIDE, ACETATE ION, ... | | 著者 | Rodriguez, I, Grudnik, P, Holak, T, Magiera-Mularz, K. | | 登録日 | 2022-08-01 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies.
Mol Cancer, 22, 2023
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8AEU
 | | Structure of hMDM2 in complex with Nutlin-3a-aa | | 分子名称: | 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2 | | 著者 | Labuzek, B, Golik, P, Magiera-Mularz, K, Berg, T. | | 登録日 | 2022-07-13 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group.
Chembiochem, 24, 2023
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8P64
 | | Co-crystal structure of PD-L1 with low molecular weight inhibitor | | 分子名称: | Programmed cell death 1 ligand 1, ~{N}-[[1-[(~{E})-2-(2-methyl-3-phenyl-phenyl)ethenyl]-1,2,3,4-tetrazol-5-yl]methyl]ethanamine | | 著者 | Plewka, J, Magiera-Mularz, K, van der Straat, R, Draijer, R, Surmiak, E, Butera, R, Land, L, Musielak, B, Domling, A. | | 登録日 | 2023-05-25 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (3.312 Å) | | 主引用文献 | 1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists.
Rsc Med Chem, 15, 2024
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8R6Q
 | | Co-crystal structure of PD-L1 with low molecular weight inhibitor | | 分子名称: | (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ... | | 著者 | Plewka, J, Surmiak, E, Magiera-Mularz, K, Kalinowska-Tluscik, J. | | 登録日 | 2023-11-22 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives.
Acs Med.Chem.Lett., 15, 2024
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6Y91
 | | Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH | | 分子名称: | Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. | | 登録日 | 2020-03-06 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Commun Biol, 4, 2021
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