8RWB
 
 | | Crystal structure of ULBP6 in complex with a blocking antibody | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bharill, S, Chen, I, Ivic, N, Bahrami Dizicheh, Z, Wu, Y, Doamekpor, S, Koenig, P, Fuh, G. | | 登録日 | 2024-02-02 | | 公開日 | 2025-02-12 | | 最終更新日 | 2025-05-07 | | 実験手法 | X-RAY DIFFRACTION (2.307 Å) | | 主引用文献 | 23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and Fc gamma RIIIa Activation.
Cancer Res Commun, 5, 2025
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7NB4
 | | Structure of Mcl-1 complex with compound 1 | | 分子名称: | (2~{R})-2-[[5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | | 著者 | Dokurno, P, Surgenor, A.E, Kotschy, A. | | 登録日 | 2021-01-25 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Acs Omega, 6, 2021
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7NB7
 | | Structure of Mcl-1 complex with compound 6b | | 分子名称: | (2~{R})-2-[[7-but-2-ynyl-5-(3-chloranyl-2-methyl-phenyl)-6-ethyl-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Dokurno, P, Surgenor, A.E, Kotschy, A. | | 登録日 | 2021-01-25 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its Analogues.
Acs Omega, 6, 2021
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4V2Y
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4V30
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4V31
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Deoxyuridine | | 分子名称: | 2'-DEOXYURIDINE, CEREBLON ISOFORM 4, CITRATE ANION, ... | | 著者 | Hartmann, M.D, Lupas, A.N, Hernandez Alvarez, B. | | 登録日 | 2014-10-15 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
J.Struct.Biol., 188, 2014
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4V2Z
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9MRB
 | | The designed serine hydrolase known as dad_t1 | | 分子名称: | TETRAETHYLENE GLYCOL, dad_t1 | | 著者 | Pellock, S.J, Lauko, A, Bera, A, Baker, D. | | 登録日 | 2025-01-07 | | 公開日 | 2025-02-19 | | 最終更新日 | 2025-04-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Computational design of serine hydrolases.
Science, 388, 2025
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4V32
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Y101F mutant | | 分子名称: | CEREBLON ISOFORM 4, S-Thalidomide, ZINC ION | | 著者 | Hartmann, M.D, Lupas, A.N, Hernandez Alvarez, B. | | 登録日 | 2014-10-15 | | 公開日 | 2014-12-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
J.Struct.Biol., 188, 2014
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3QA9
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1YFM
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9DEE
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9DEH
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9DED
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9DEG
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9DEF
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8VC8
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8VEI
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8VEJ
 | | De novo designed cholic acid binder: CHD_buttress | | 分子名称: | CHD_buttress, CHOLIC ACID | | 著者 | Bera, A.K, Tran, L, Kang, A, Baker, D. | | 登録日 | 2023-12-19 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-07-31 | | 実験手法 | X-RAY DIFFRACTION (3.59 Å) | | 主引用文献 | Binding and sensing diverse small molecules using shape-complementary pseudocycles.
Science, 385, 2024
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4C46
 | | ANDREI-N-LVPAS fused to GCN4 adaptors | | 分子名称: | BROMIDE ION, GENERAL CONTROL PROTEIN GCN4 | | 著者 | Albrecht, R, Alva, V, Ammelburg, M, Baer, K, Basina, E, Boichenko, I, Bonhoeffer, F, Braun, V, Chaubey, M, Chauhan, N, Chellamuthu, V.R, Coles, M, Deiss, S, Ewers, C.P, Forouzan, D, Fuchs, A, Groemping, Y, Hartmann, M.D, Hernandez Alvarez, B, Jeganantham, A, Kalev, I, Koenninger, U, Koiwai, K, Kopec, K.O, Korycinski, M, Laudenbach, B, Lehmann, K, Leo, J.C, Linke, D, Marialke, J, Martin, J, Mechelke, M, Michalik, M, Noll, A, Patzer, S.I, Scharfenberg, F, Schueckel, M, Shahid, S.A, Sulz, E, Ursinus, A, Wuertenberger, S, Zhu, H. | | 登録日 | 2013-08-30 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Your Personalized Protein Structure: Andrei N. Lupas Fused to GCN4 Adaptors.
J.Struct.Biol., 186, 2014
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8DT0
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8CYK
 | | Crystal structure of hallucinated protein HALC1_878 | | 分子名称: | HALC1_878 | | 著者 | Ragotte, R.J, Bera, A.K, Milles, L.F, Wicky, B.I.M, Baker, D. | | 登録日 | 2022-05-23 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Robust deep learning-based protein sequence design using ProteinMPNN.
Science, 378, 2022
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8UQF
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5AMK
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in multiple conformations, hexagonal crystal form | | 分子名称: | CEREBLON ISOFORM 4, DIMETHYL SULFOXIDE, S-Thalidomide, ... | | 著者 | Hartmann, M.D, Lupas, A.N, Hernandez Alvarez, B. | | 登録日 | 2015-03-10 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Dynamics of the Cereblon Ligand Binding Domain.
Plos One, 10, 2015
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5AMJ
 | | Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Thalidomide, Wash II structure | | 分子名称: | CEREBLON ISOFORM 4, PHOSPHATE ION, S-Thalidomide, ... | | 著者 | Hartmann, M.D, Lupas, A.N, Hernandez Alvarez, B. | | 登録日 | 2015-03-10 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Dynamics of the Cereblon Ligand Binding Domain.
Plos One, 10, 2015
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