4V2Z

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with Pomalidomide

Summary for 4V2Z

Entry DOI	10.2210/pdb4v2z/pdb
Related	4V2Y 4V30 4V31 4V32
Descriptor	CEREBLON ISOFORM 4, ZINC ION, S-Pomalidomide, ... (4 entities in total)
Functional Keywords	signaling protein, teratogenicity, aromatic cage, cc-4047, pomalyst
Biological source	MAGNETOSPIRILLUM GRYPHISWALDENSE
Total number of polymer chains	3
Total formula weight	42126.69
Authors	Hartmann, M.D.,Lupas, A.N.,Hernandez Alvarez, B. (deposition date: 2014-10-15, release date: 2014-12-17)
Primary citation	Hartmann, M.D.,Boichenko, I.,Coles, M.,Zanini, F.,Lupas, A.N.,Hernandez Alvarez, B. Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon. J.Struct.Biol., 188:225-, 2014 Cited by PubMed: 25448889 DOI: 10.1016/J.JSB.2014.10.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation