8RWB

Crystal structure of ULBP6 in complex with a blocking antibody

Summary for 8RWB

• Entry DOI: 10.2210/pdb8rwb/pdb
• Descriptor: UL16-binding protein 6, Heavy chain, Light chain, ... (8 entities in total)
• Functional Keywords: fab, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 66627.43

Authors

Bharill, S.,Chen, I.,Ivic, N.,Bahrami Dizicheh, Z.,Wu, Y.,Doamekpor, S.,Koenig, P.,Fuh, G. (deposition date: 2024-02-02, release date: 2025-02-12, Last modification date: 2025-05-07)

Primary citation

Benjamin, J.S.,Jarret, A.,Bharill, S.,Fontanillas, P.,Yadav, S.,Sen, D.,Ayupova, D.,Kellar, D.,Tilk, S.,Hom, C.,Bahrami Dizicheh, Z.,Chen, I.L.,Diep, A.N.,Shi, S.,Ivic, N.,Bonnans, C.,Owyang, A.,Sood, P.,Fuh, G.,Schmidt, M.,Gerrick, K.Y.,Koenig, P.,Poggio, M.
23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and Fc gamma RIIIa Activation.
Cancer Res Commun, 5:476-495, 2025

PubMed Abstract: This study emphasizes the utility of population-based genome-wide assessments for discovering naturally occurring genetic variants associated with lifetime risks for cancer or immune diseases as novel drug targets. We identify ULBP6 as a potential keystone member of the NKG2D pathway, which is important for antitumor immunity. Targeting ULBP6 may hold therapeutic promise for patients with cancer.

PubMed: 40116579
DOI: 10.1158/2767-9764.CRC-24-0478

Experimental method

X-RAY DIFFRACTION (2.307 Å)