8D7H
 
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8D82
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8D85
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5UZK
 | | Crystal Structure of PKA bound to an pyrrolo pyridine inhibitor | | 分子名称: | 2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamide, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | | 著者 | Jacobs, M.D, Brown, K. | | 登録日 | 2017-02-26 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
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2OJG
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2OJJ
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2OJI
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2OK1
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5HVU
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7KKE
 | | Phosphoinositide 3-Kinase gamma bound to a thiazole inhibitor | | 分子名称: | N-[2-(3,3-dimethylbutoxy)ethyl]-N'-{4-methyl-5-[(pyridin-4-yl)ethynyl]-1,3-thiazol-2-yl}urea, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | | 著者 | Jacobs, M.D, Griffith, J.P. | | 登録日 | 2020-10-27 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K gamma Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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2PST
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8FW1
 | | Gluconobacter Ene-Reductase (GluER) mutant - PagER | | 分子名称: | FLAVIN MONONUCLEOTIDE, N-ethylmaleimide reductase | | 著者 | Dahagam, S, Page, C, Patterson, M.G, Hyster, T.K. | | 登録日 | 2023-01-20 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes.
J.Am.Chem.Soc., 145, 2023
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2H8N
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7KNU
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7KNT
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3BJK
 | | Crystal structure of HI0827, a hexameric broad specificity acyl-coenzyme A thioesterase: The Asp44Ala mutant enzyme | | 分子名称: | 1,2-ETHANEDIOL, Acyl-CoA thioester hydrolase HI0827, CITRIC ACID | | 著者 | Willis, M.A, Herzberg, O, Structure 2 Function Project (S2F) | | 登録日 | 2007-12-04 | | 公開日 | 2008-02-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of YciA from Haemophilus influenzae (HI0827), a Hexameric Broad Specificity Acyl-Coenzyme A Thioesterase.
Biochemistry, 47, 2008
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4FA0
 | | Crystal structure of human AdPLA to 2.65 A resolution | | 分子名称: | Group XVI phospholipase A1/A2 | | 著者 | Lovell, S, Battaile, K.P, Addington, L, Zhang, N, Rao, J.L.U.M, Moise, A.R. | | 登録日 | 2012-05-21 | | 公開日 | 2012-06-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structure/Function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad.
J.Biol.Chem., 287, 2012
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7E4I
 | | Cryo-EM structure of the yeast mitochondrial SAM-Tom40/Tom5/Tom6 complex at 3.0 angstrom | | 分子名称: | Mitochondrial import receptor subunit TOM40, Mitochondrial import receptor subunit TOM5, Mitochondrial import receptor subunit TOM6, ... | | 著者 | Wang, Q, Guan, Z.Y, Qi, L.B, Yan, C.Y, Yin, P. | | 登録日 | 2021-02-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Science, 373, 2021
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7E4H
 | | Cryo-EM structure of the yeast mitochondrial SAM-Tom40 complex at 3.0 angstrom | | 分子名称: | Mitochondrial import receptor subunit TOM40, Sorting assembly machinery 35 kDa subunit, Sorting assembly machinery 37 kDa subunit, ... | | 著者 | Wang, Q, Guan, Z.Y, Qi, L.B, Yan, C.Y, Yin, P. | | 登録日 | 2021-02-13 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.
Science, 373, 2021
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2O94
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7TV3
 | | LH2-LH3 antenna in parallel configuration embedded in a nanodisc | | 分子名称: | BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... | | 著者 | Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. | | 登録日 | 2022-02-03 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (11.4 Å) | | 主引用文献 | Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7TUW
 | | LH2-LH3 antenna in anti parallel configuration embedded in a nanodisc | | 分子名称: | BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... | | 著者 | Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. | | 登録日 | 2022-02-03 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | | 主引用文献 | Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7TNB
 | | Caulobacter segnis arene reductase (CSAR) - WT | | 分子名称: | ACETATE ION, FLAVIN MONONUCLEOTIDE, NADH:flavin oxidoreductase/NADH oxidase, ... | | 著者 | Garfinkle, S.E, Jeffrey, P, Hyster, T.K. | | 登録日 | 2022-01-20 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | An asymmetric sp 3 -sp 3 cross-electrophile coupling using 'ene'-reductases.
Nature, 610, 2022
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6C1S
 | | Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor | | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile | | 著者 | Jacobs, M.D, Griffin, J.P. | | 登録日 | 2018-01-05 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
J. Med. Chem., 61, 2018
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8FB9
 | | LH2-LH3 antenna in anti parallel configuration embedded in a nanodisc | | 分子名称: | BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... | | 著者 | Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. | | 登録日 | 2022-11-29 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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