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5IMX
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Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
分子名称: 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine, ALK tyrosine kinase receptor
著者Wang, C, Zhang, P, Dong, J.
登録日2016-03-07
公開日2016-05-04
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
1L0Q
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BU of 1l0q by Molmil
Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein
分子名称: Surface layer protein
著者Jing, H, Takagi, J, Liu, J.-H, Lindgren, S, Zhang, R.-G, Joachimiak, A, Wang, J.-H, Springer, T.A.
登録日2002-02-12
公開日2002-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Archaeal Surface Layer Proteins Contain beta Propeller, PKD, and beta Helix Domains and Are Related to Metazoan Cell Surface Proteins.
Structure, 10, 2002
5F6I
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BU of 5f6i by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
分子名称: DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
6EB0
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BU of 6eb0 by Molmil
STRUCTURE OF 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (HPAB), OXYGENASE COMPONENT FROM ESCHERICHIA COLI
分子名称: 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit, ACETATE ION
著者Zhou, D, Kandavelu, P, Zhang, H, Wang, B.C, Yan, Y, Rose, J.
登録日2018-08-03
公開日2019-05-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli.
Sci Rep, 9, 2019
2O8M
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BU of 2o8m by Molmil
Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
分子名称: Protease, SODIUM ION, ZINC ION
著者Fischmann, T.O, Prongay, A.J, Madison, V.M, Yao, N.
登録日2006-12-12
公開日2007-10-09
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization
J.Med.Chem., 50, 2007
5Z9J
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BU of 5z9j by Molmil
Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme, TRIS(HYDROXYETHYL)AMINOMETHANE
著者Lu, M, Lin, L, Zhang, C, Chen, Y.
登録日2018-02-03
公開日2019-02-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.
Chembiochem, 2020
1YY6
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BU of 1yy6 by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide
分子名称: Epstein-Barr nuclear antigen-1, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
著者Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M, Shire, K, Nguyen, T, Zhang, R, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L.
登録日2005-02-23
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
5Z9I
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BU of 5z9i by Molmil
Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme
著者Lu, M, Lin, L, Zhang, C, Chen, Y.
登録日2018-02-03
公開日2019-02-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.
Chembiochem, 2020
5GI4
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BU of 5gi4 by Molmil
DEAD-box RNA helicase
分子名称: ATP-dependent RNA helicase DeaD
著者Xu, L, Wang, L, Li, F, Wu, L, Shi, Y.
登録日2016-06-22
公開日2017-05-31
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.244 Å)
主引用文献Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
5GJU
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BU of 5gju by Molmil
DEAD-box RNA helicase
分子名称: ADENOSINE MONOPHOSPHATE, ATP-dependent RNA helicase DeaD
著者Xu, L, Li, F, Wang, L, Shi, Y.
登録日2016-07-02
公開日2017-05-31
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
2ZN7
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BU of 2zn7 by Molmil
CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes
分子名称: 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 1
著者Xu, W, Wu, J.
登録日2008-04-22
公開日2008-10-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Chemmedchem, 3, 2008
5F6H
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BU of 5f6h by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque
分子名称: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6J
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BU of 5f6j by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
分子名称: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
著者Fera, D, Harrison, S.C.
登録日2015-12-06
公開日2016-01-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (6.63 Å)
主引用文献Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
4QQY
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BU of 4qqy by Molmil
Crystal structure of T. fusca Cas3-ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ...
著者Ke, A, Huo, Y, Nam, K.H.
登録日2014-06-30
公開日2014-08-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
4QQX
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BU of 4qqx by Molmil
Crystal structure of T. fusca Cas3-ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ...
著者Ke, A, Huo, Y, Nam, K.H.
登録日2014-06-30
公開日2014-08-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.34 Å)
主引用文献Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
4QQW
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BU of 4qqw by Molmil
Crystal structure of T. fusca Cas3
分子名称: CRISPR-associated helicase, Cas3 family, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ...
著者Ke, A, Huo, Y, Nam, K.H.
登録日2014-06-30
公開日2014-08-27
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.664 Å)
主引用文献Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
2DVA
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BU of 2dva by Molmil
Crystal structure of peanut lectin GAL-BETA-1,3-GALNAC-ALPHA-O-ME (Methyl-T-antigen) complex
分子名称: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
著者Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
登録日2006-07-30
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DVG
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BU of 2dvg by Molmil
Crystal structure of peanut lectin GAL-ALPHA-1,6-GLC complex
分子名称: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
著者Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
登録日2006-07-31
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DVD
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BU of 2dvd by Molmil
Crystal structure of peanut lectin GAL-ALPHA-1,3-GAL complex
分子名称: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
著者Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
登録日2006-07-31
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DV9
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BU of 2dv9 by Molmil
Crystal structure of peanut lectin GAL-BETA-1,3-GAL complex
分子名称: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
著者Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
登録日2006-07-30
公開日2006-11-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
5U0U
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BU of 5u0u by Molmil
Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.1 single-chain variable fragment
著者Fera, D, Harrison, S.C.
登録日2016-11-27
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.428 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U0R
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BU of 5u0r by Molmil
Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.UCA1 heavy chain, DH270.UCA1 light chain, SULFATE ION
著者Fera, D, Harrison, S.C.
登録日2016-11-26
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.295 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5INW
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BU of 5inw by Molmil
Structure of reaction loop cleaved lamprey angiotensinogen
分子名称: C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION
著者Wei, H, Zhou, A.
登録日2016-03-08
公開日2016-10-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
5TPL
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BU of 5tpl by Molmil
Crystal Structure of DH270.3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
分子名称: DH270.3 Fab heavy chain, DH270.3 Fab light chain
著者Fera, D, Harrison, S.C.
登録日2016-10-20
公開日2017-03-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
6A68
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the crystal structure of rat calcium-dependent activator protein for secretion (CAPS) DAMH domain
分子名称: Calcium-dependent secretion activator 1, POTASSIUM ION
著者Zhou, H, Wei, Z.Q, Yao, D.Q, Zhang, R.G, Ma, C.
登録日2018-06-26
公開日2019-03-13
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.
Cell Rep, 26, 2019

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