6LXB
 
 | | X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by soaking | | 分子名称: | (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Peroxisome proliferator-activated receptor alpha | | 著者 | Kamata, S, Honda, A, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. | | 登録日 | 2020-02-10 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
Iscience, 23, 2020
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7KQL
 | | Anti-Tim3 antibody Fab complex | | 分子名称: | GLYCEROL, Hepatitis A virus cellular receptor 2, Tim3.18 Fab heavy chain, ... | | 著者 | Deng, X.A, West, S.M, Strop, P. | | 登録日 | 2020-11-16 | | 公開日 | 2022-02-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Tim-3 mediates T cell trogocytosis to limit antitumor immunity.
J.Clin.Invest., 132, 2022
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6KKT
 | | human KCC1 structure determined in KCl and lipid nanodisc | | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | | 登録日 | 2019-07-27 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-08-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
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6KKU
 | | human KCC1 structure determined in NaCl and GDN | | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | | 登録日 | 2019-07-27 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
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6KKR
 | | human KCC1 structure determined in KCl and detergent GDN | | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Liu, S, Chang, S, Ye, S, Bai, X, Guo, J. | | 登録日 | 2019-07-27 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-08-12 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of the human cation-chloride cotransporter KCC1.
Science, 366, 2019
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7B1O
 | | Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complex with compound 22 | | 分子名称: | 4-chloranyl-N-[(1R)-1-[(1S,5R)-3-quinolin-4-yloxy-6-bicyclo[3.1.0]hexanyl]propyl]benzamide, Indoleamine 2,3-dioxygenase 1 | | 著者 | Lammens, A, Krapp, S, Lewis, R.T, Hamilton, M.M. | | 登録日 | 2020-11-25 | | 公開日 | 2021-09-29 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J.Med.Chem., 64, 2021
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6MBZ
 | | Structure of Transcription Factor | | 分子名称: | Signal transducer and activator of transcription 5B | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2018-08-30 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
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6KUR
 | | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B1) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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6KUK
 | | Structure of influenza D virus polymerase bound to vRNA promoter in mode A conformation (class A1) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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6KUP
 | | Structure of influenza D virus polymerase bound to vRNA promoter in Mode A conformation(Class A2) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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6KUV
 | | Structure of influenza D virus polymerase bound to cRNA promoter in class 2 | | 分子名称: | 3'-cRNA, 5'-cRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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6KUT
 | | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B2) | | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | | 登録日 | 2019-09-02 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural insight into RNA synthesis by influenza D polymerase.
Nat Microbiol, 4, 2019
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7W3X
 | | Cryo-EM structure of plant receptor like protein RXEG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Membrane-localized LRR receptor-like protein, ... | | 著者 | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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7W3V
 | | Plant receptor like protein RXEG1 in complex with xyloglucanase XEG1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cell 12A endoglucanase, ... | | 著者 | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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7W3T
 | | Cryo-EM structure of plant receptor like kinase NbBAK1 in RXEG1-BAK1-XEG1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Brassinosteroid insensitive 1-associated receptor kinase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Sun, Y, Wang, Y, Zhang, X.X, Chen, Z.D, Xia, Y.Q, Sun, Y.J, Zhang, M.M, Xiao, Y, Han, Z.F, Wang, Y.C, Chai, J.J. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-22 | | 最終更新日 | 2022-10-26 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Plant receptor-like protein activation by a microbial glycoside hydrolase.
Nature, 610, 2022
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5XN4
 | | Anti-CRISPR protein AcrIIA4 | | 分子名称: | Anti-CRISPR AcrIIA4 | | 著者 | Suh, J.-Y, Kim, I. | | 登録日 | 2017-05-17 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and dynamics of anti-CRISPR AcrIIA4, the Cas9 inhibitor.
Sci Rep, 8, 2018
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5YXA
 | | Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus | | 分子名称: | Non-structural protein 1 | | 著者 | Wang, H, Song, H, Qi, J, Shi, Y, Gao, G.F. | | 登録日 | 2017-12-04 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus.
Sci China Life Sci, 60, 2017
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7W0N
 | | Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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7W0L
 | | Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule | | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yue, Y, Liu, L.E, Wu, L.J, Xu, F, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 最終更新日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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7W0M
 | | Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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7W0O
 | | Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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7W0P
 | | Cryo-EM structure of a GPCR-Gi complex with peptide | | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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6ISS
 | | Lignin peroxidase H8 triple mutant S49C/A67C/H239 | | 分子名称: | CALCIUM ION, Ligninase H8, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Seo, H, Son, H, Kim, K.-J. | | 登録日 | 2018-11-19 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Extra disulfide and ionic salt bridge improves the thermostability of lignin peroxidase H8 under acidic condition
Enzyme.Microb.Technol., 148, 2021
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7T3F
 | | Development of BRD4 inhibitors as arsenicals antidotes | | 分子名称: | 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, Bromodomain-containing protein 4, GLYCEROL | | 著者 | Wu, M, Yatchang, M, Mathew, B, Zhai, L, Ruiz, P, Bostwick, R, Augelli-Szafran, C.E, Suto, M.J. | | 登録日 | 2021-12-07 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals.
Bioorg.Med.Chem.Lett., 64, 2022
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6MAJ
 | | HBO1 is required for the maintenance of leukaemia stem cells | | 分子名称: | 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide, BRD1 protein, GLYCEROL, ... | | 著者 | Ren, B, Peat, T.S, Monahan, B, Dawson, M, Street, I. | | 登録日 | 2018-08-27 | | 公開日 | 2019-12-25 | | 最終更新日 | 2020-01-22 | | 実験手法 | X-RAY DIFFRACTION (2.139 Å) | | 主引用文献 | HBO1 is required for the maintenance of leukaemia stem cells.
Nature, 577, 2020
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