3UO8
 
 | | Crystal structure of the MALT1 paracaspase (P1 form) | | 分子名称: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | | 著者 | Jeffrey, P.D, Yu, J.W, Shi, Y. | | 登録日 | 2011-11-16 | | 公開日 | 2011-12-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region.
Proc.Natl.Acad.Sci.USA, 108, 2011
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7XST
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5DO4
 | | Thrombin-RNA aptamer complex | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2015-09-10 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.859 Å) | | 主引用文献 | Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
Nucleic Acids Res., 44, 2016
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5AYW
 | | Structure of a membrane complex | | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | | 著者 | Huang, Y, Han, L, Zheng, J. | | 登録日 | 2015-09-14 | | 公開日 | 2016-02-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.555 Å) | | 主引用文献 | Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
Nat.Struct.Mol.Biol., 23, 2016
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5DK3
 | | Crystal Structure of Pembrolizumab, a full length IgG4 antibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ... | | 著者 | Scapin, G, Prosise, W, Reichert, P. | | 登録日 | 2015-09-02 | | 公開日 | 2015-11-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab.
Nat.Struct.Mol.Biol., 22, 2015
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3SJ1
 | | PpcA M58D mutant | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CYTOCHROME C7, HEME C, ... | | 著者 | Pokkuluri, P.R, Schiffer, M. | | 登録日 | 2011-06-20 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pitfalls in the interpretation of structural changes in mutant proteins from crystal structures.
J.Struct.Funct.Genom., 13, 2012
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3SJ0
 | | PpcA mutant M58S | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CYTOCHROME C7, HEME C, ... | | 著者 | Pokkuluri, P.R, Schiffer, M. | | 登録日 | 2011-06-20 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Pitfalls in the interpretation of structural changes in mutant proteins from crystal structures.
J.Struct.Funct.Genom., 13, 2012
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3SJ4
 | | PpcA mutant M58K | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CYTOCHROME C7, HEME C, ... | | 著者 | Pokkuluri, P.R, Schiffer, M. | | 登録日 | 2011-06-20 | | 公開日 | 2012-07-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pitfalls in the interpretation of structural changes in mutant proteins from crystal structures.
J.Struct.Funct.Genom., 13, 2012
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3SEL
 | | PpcA M58N mutant | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, CYTOCHROME C7, HEME C, ... | | 著者 | Pokkuluri, P.R, Schiffer, M. | | 登録日 | 2011-06-10 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Pitfalls in the interpretation of structural changes in mutant proteins from crystal structures.
J.Struct.Funct.Genom., 13, 2012
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7YDX
 | | Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | | 分子名称: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | | 著者 | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | | 登録日 | 2022-07-04 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | | 主引用文献 | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.
Nat Commun, 13, 2022
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6IWI
 | | Crystal structure of PDE5A in complex with a novel inhibitor | | 分子名称: | MAGNESIUM ION, N-[3-(4,5-diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide, ZINC ION, ... | | 著者 | Zhang, X.L, Xu, Y.C. | | 登録日 | 2018-12-05 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.155 Å) | | 主引用文献 | Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
J.Med.Chem., 62, 2019
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6JM5
 | | Crystal structure of TBC1D23 C terminal domain | | 分子名称: | SODIUM ION, TBC1 domain family member 23 | | 著者 | Sun, Q, Huang, W. | | 登録日 | 2019-03-07 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH.
Proc.Natl.Acad.Sci.USA, 116, 2019
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4IA0
 | | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | | 分子名称: | 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... | | 著者 | Ren, J, Chen, T, Xu, Y. | | 登録日 | 2012-12-05 | | 公開日 | 2014-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
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8Y8C
 | | Structure of HCoV-HKU1C spike in the inactive-closed conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y8D
 | | Structure of HCoV-HKU1C spike in the inactive-1up conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y8I
 | | Structure of HCoV-HKU1C spike in the glycan-activated-3up conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y89
 | | Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Wang, H.F, Zhang, X, Liu, X.C, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y8E
 | | Structure of HCoV-HKU1C spike in the inactive-2up conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y88
 | | Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y7X
 | | Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T. | | 登録日 | 2024-02-05 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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4K5U
 | | Recognition of the BG-H Antigen by a Lamprey Variable Lymphocyte Receptor | | 分子名称: | Variable lymphocyte receptor, beta-D-galactopyranose | | 著者 | Luo, M, Velikovsky, C.A, Yang, X.B, Mariuzza, R.A. | | 登録日 | 2013-04-15 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | | 主引用文献 | Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
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8Y8G
 | | Structure of HCoV-HKU1C spike in the glycan-activated-1up conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y87
 | | Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Liu, X.C, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y8B
 | | Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Wang, H.F, Zhang, X, Lu, Y.C, Liu, X.C, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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8Y8H
 | | Structure of HCoV-HKU1C spike in the glycan-activated-2up conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Lu, Y.C, Zhang, X, Wang, H.F, Sun, L, Yang, H.T. | | 登録日 | 2024-02-06 | | 公開日 | 2024-07-17 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Cell, 187, 2024
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