8Y7X

Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2

Summary for 8Y7X

Entry DOI	10.2210/pdb8y7x/pdb
EMDB information	39025
Descriptor	Spike glycoprotein, Transmembrane protease serine 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	hku1a, spike, tmprss2, viral protein
Biological source	Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) More
Total number of polymer chains	6
Total formula weight	559888.67
Authors	Lu, Y.C.,Zhang, X.,Wang, H.F.,Liu, X.C.,Sun, L.,Yang, H.T. (deposition date: 2024-02-05, release date: 2024-07-17)
Primary citation	Wang, H.,Liu, X.,Zhang, X.,Zhao, Z.,Lu, Y.,Pu, D.,Zhang, Z.,Chen, J.,Wang, Y.,Li, M.,Dong, X.,Duan, Y.,He, Y.,Mao, Q.,Guo, H.,Sun, H.,Zhou, Y.,Yang, Q.,Gao, Y.,Yang, X.,Cao, H.,Guddat, L.,Sun, L.,Rao, Z.,Yang, H. TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. Cell, 2024 Cited by PubMed: 38964329 DOI: 10.1016/j.cell.2024.06.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.09 Å)

Structure validation