4WRN
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![BU of 4wrn by Molmil](/molmil-images/mine/4wrn) | Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltose-binding periplasmic protein,Uromodulin, ZINC ION, ... | 著者 | Bokhove, M, De Sanctis, D, Jovine, L. | 登録日 | 2014-10-24 | 公開日 | 2016-01-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A structured interdomain linker directs self-polymerization of human uromodulin. Proc.Natl.Acad.Sci.USA, 113, 2016
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6DBK
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![BU of 6dbk by Molmil](/molmil-images/mine/6dbk) | Tyk2 with compound 8 | 分子名称: | 4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-N-ethylbenzamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Vajdos, F.F. | 登録日 | 2018-05-03 | 公開日 | 2018-08-29 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
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6DBM
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![BU of 6dbm by Molmil](/molmil-images/mine/6dbm) | Tyk2 with compound 23 | 分子名称: | Non-receptor tyrosine-protein kinase TYK2, [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Vajdos, F.F. | 登録日 | 2018-05-03 | 公開日 | 2018-08-29 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (2.368 Å) | 主引用文献 | Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
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6DBN
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![BU of 6dbn by Molmil](/molmil-images/mine/6dbn) | Jak1 with compound 23 | 分子名称: | Tyrosine-protein kinase JAK1, [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Vajdos, F.F. | 登録日 | 2018-05-03 | 公開日 | 2018-08-29 | 最終更新日 | 2018-11-07 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
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5KIT
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![BU of 5kit by Molmil](/molmil-images/mine/5kit) | |
6KZC
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![BU of 6kzc by Molmil](/molmil-images/mine/6kzc) | crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide | 分子名称: | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide, NT-3 growth factor receptor | 著者 | Zhang, Z.M, Wang, Y. | 登録日 | 2019-09-23 | 公開日 | 2019-10-09 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. Eur.J.Med.Chem., 179, 2019
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7D7L
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![BU of 7d7l by Molmil](/molmil-images/mine/7d7l) | The crystal structure of SARS-CoV-2 papain-like protease in complex with YM155 | 分子名称: | 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione, CAFFEINE, GLYCEROL, ... | 著者 | Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. | 登録日 | 2020-10-04 | 公開日 | 2021-04-21 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell, 12, 2021
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7D7K
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![BU of 7d7k by Molmil](/molmil-images/mine/7d7k) | The crystal structure of SARS-CoV-2 papain-like protease in apo form | 分子名称: | 1,2-ETHANEDIOL, CAFFEINE, Non-structural protein 3, ... | 著者 | Zhao, Y, Sun, L, Yang, H.T, Rao, Z.H. | 登録日 | 2020-10-04 | 公開日 | 2021-04-21 | 最終更新日 | 2021-11-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. Protein Cell, 12, 2021
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7YHQ
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![BU of 7yhq by Molmil](/molmil-images/mine/7yhq) | |
7YHO
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![BU of 7yho by Molmil](/molmil-images/mine/7yho) | |
7YHP
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![BU of 7yhp by Molmil](/molmil-images/mine/7yhp) | |
5GSX
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![BU of 5gsx by Molmil](/molmil-images/mine/5gsx) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-2 | 分子名称: | 10-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | 登録日 | 2016-08-17 | 公開日 | 2017-06-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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7WK0
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![BU of 7wk0 by Molmil](/molmil-images/mine/7wk0) | Local refine of Omicron spike bitrimer with 6m6 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | 著者 | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | 登録日 | 2022-01-08 | 公開日 | 2022-07-13 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res., 32, 2022
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7WJY
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![BU of 7wjy by Molmil](/molmil-images/mine/7wjy) | Omicron spike trimer with 6m6 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | 著者 | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | 登録日 | 2022-01-08 | 公開日 | 2022-07-13 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res., 32, 2022
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7WJZ
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![BU of 7wjz by Molmil](/molmil-images/mine/7wjz) | Omicron Spike bitrimer with 6m6 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6m6 heavy chain, 6m6 light chain, ... | 著者 | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | 登録日 | 2022-01-08 | 公開日 | 2022-07-13 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res., 32, 2022
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5GSV
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![BU of 5gsv by Molmil](/molmil-images/mine/5gsv) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 142-5 | 分子名称: | 10-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | 登録日 | 2016-08-17 | 公開日 | 2017-04-26 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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5GSR
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![BU of 5gsr by Molmil](/molmil-images/mine/5gsr) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide I5A | 分子名称: | 9-mer peptide from Spike protein, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | 登録日 | 2016-08-17 | 公開日 | 2017-04-26 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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5GR7
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![BU of 5gr7 by Molmil](/molmil-images/mine/5gr7) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-1 | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | 登録日 | 2016-08-08 | 公開日 | 2017-06-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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5GSB
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![BU of 5gsb by Molmil](/molmil-images/mine/5gsb) | Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-3 | 分子名称: | Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... | 著者 | Liu, K, Chai, Y, Qi, J, Tan, W, Liu, W.J, Gao, G.F. | 登録日 | 2016-08-15 | 公開日 | 2017-07-12 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8+ T Cell Epitopes and Host MHC. J. Immunol., 198, 2017
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5KH5
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![BU of 5kh5 by Molmil](/molmil-images/mine/5kh5) | |
2RBE
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![BU of 2rbe by Molmil](/molmil-images/mine/2rbe) | The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors | 分子名称: | (5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zhang, J, Jordan, S.R, Li, V. | 登録日 | 2007-09-18 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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5KH4
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![BU of 5kh4 by Molmil](/molmil-images/mine/5kh4) | |
3HFD
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![BU of 3hfd by Molmil](/molmil-images/mine/3hfd) | |
5KH2
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![BU of 5kh2 by Molmil](/molmil-images/mine/5kh2) | |
5DJ4
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![BU of 5dj4 by Molmil](/molmil-images/mine/5dj4) | |