6CRG
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![BU of 6crg by Molmil](/molmil-images/mine/6crg) | Crystal Structure of Shp2 E76K GOF Mutant in complex with SHP099 | 分子名称: | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, GLYCEROL, SULFATE ION, ... | 著者 | Stams, T, Fodor, M. | 登録日 | 2018-03-17 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9, 2018
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3B7R
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![BU of 3b7r by Molmil](/molmil-images/mine/3b7r) | Leukotriene A4 Hydrolase Complexed with Inhibitor RB3040 | 分子名称: | IMIDAZOLE, Leukotriene A-4 hydrolase, N-[3-[(1-AMINOETHYL)(HYDROXY)PHOSPHORYL]-2-(1,1'-BIPHENYL-4-YLMETHYL)PROPANOYL]ALANINE, ... | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | 登録日 | 2007-10-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.811 Å) | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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3K8G
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![BU of 3k8g by Molmil](/molmil-images/mine/3k8g) | Structure of crystal form I of TP0453 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 30kLP | 著者 | Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G. | 登録日 | 2009-10-14 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices. J.Biol.Chem., 286, 2011
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3K8I
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![BU of 3k8i by Molmil](/molmil-images/mine/3k8i) | Structure of crystal form IV of TP0453 | 分子名称: | 30kLP | 著者 | Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G. | 登録日 | 2009-10-14 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices. J.Biol.Chem., 286, 2011
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3B7S
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![BU of 3b7s by Molmil](/molmil-images/mine/3b7s) | [E296Q]LTA4H in complex with RSR substrate | 分子名称: | ACETIC ACID, GLYCEROL, Leukotriene A-4 hydrolase, ... | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | 登録日 | 2007-10-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.465 Å) | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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6CRF
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![BU of 6crf by Molmil](/molmil-images/mine/6crf) | |
3B7T
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![BU of 3b7t by Molmil](/molmil-images/mine/3b7t) | [E296Q]LTA4H in complex with Arg-Ala-Arg substrate | 分子名称: | IMIDAZOLE, Leukotriene A-4 hydrolase, RAR peptide, ... | 著者 | Tholander, F, Haeggstrom, J, Thunnissen, M, Muroya, A, Roques, B.-P, Fournie-Zaluski, M.-C. | 登録日 | 2007-10-31 | 公開日 | 2008-09-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design. Chem.Biol., 15, 2008
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3K8H
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![BU of 3k8h by Molmil](/molmil-images/mine/3k8h) | Structure of crystal form I of TP0453 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 30kLP | 著者 | Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G. | 登録日 | 2009-10-14 | 公開日 | 2010-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices. J.Biol.Chem., 286, 2011
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4YWN
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![BU of 4ywn by Molmil](/molmil-images/mine/4ywn) | |
3K8J
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![BU of 3k8j by Molmil](/molmil-images/mine/3k8j) | Structure of crystal form III of TP0453 | 分子名称: | 30kLP | 著者 | Zhu, G, Luthra, A, Desrosiers, D, Koszelak-Rosenblum, M, Mulay, V, Radolf, J.D, Malkowski, M.G. | 登録日 | 2009-10-14 | 公開日 | 2010-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices. J.Biol.Chem., 286, 2011
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6BN5
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![BU of 6bn5 by Molmil](/molmil-images/mine/6bn5) | Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2 | 分子名称: | 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | 登録日 | 2017-11-16 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg. Med. Chem., 25, 2017
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4J6V
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![BU of 4j6v by Molmil](/molmil-images/mine/4j6v) | Crystal Structure of Tyrosinase from Bacillus megaterium N205D mutant | 分子名称: | COPPER (II) ION, Tyrosinase | 著者 | Kanteev, M, Goldfeder, M, Adir, N, Fishman, A. | 登録日 | 2013-02-12 | 公開日 | 2013-12-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The mechanism of copper uptake by tyrosinase from Bacillus megaterium. J.Biol.Inorg.Chem., 18, 2013
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4J6T
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![BU of 4j6t by Molmil](/molmil-images/mine/4j6t) | Crystal Structure of Tyrosinase from Bacillus megaterium F197A mutant | 分子名称: | COPPER (II) ION, Tyrosinase | 著者 | Kanteev, M, Goldfeder, M, Adir, N, Fishman, A. | 登録日 | 2013-02-12 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | The mechanism of copper uptake by tyrosinase from Bacillus megaterium. J.Biol.Inorg.Chem., 18, 2013
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4OXF
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4J6U
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5DN5
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![BU of 5dn5 by Molmil](/molmil-images/mine/5dn5) | Structure of a C-terminally truncated glycoside hydrolase domain from Salmonella typhimurium FlgJ | 分子名称: | CHLORIDE ION, IODIDE ION, Peptidoglycan hydrolase FlgJ, ... | 著者 | Zaloba, P, Bailey-Elkin, B.A, Mark, B.L. | 登録日 | 2015-09-09 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural and Biochemical Insights into the Peptidoglycan Hydrolase Domain of FlgJ from Salmonella typhimurium. Plos One, 11, 2016
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4CIK
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![BU of 4cik by Molmil](/molmil-images/mine/4cik) | plasminogen kringle 1 in complex with inhibitor | 分子名称: | 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN | 著者 | Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D. | 登録日 | 2013-12-10 | 公開日 | 2014-06-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction. Acs Med.Chem.Lett., 5, 2014
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8CHF
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![BU of 8chf by Molmil](/molmil-images/mine/8chf) | cryo-EM Structure of Craf:14-3-3:Mek1 | 分子名称: | 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Dedden, D, Ulrich, G. | 登録日 | 2023-02-07 | 公開日 | 2024-02-21 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.25 Å) | 主引用文献 | Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
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7V62
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![BU of 7v62 by Molmil](/molmil-images/mine/7v62) | Crystal structure of human OSBP ORD in complex with cholesterol | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHOLESTEROL, CITRIC ACID, ... | 著者 | Kobayashi, J, Kato, R. | 登録日 | 2021-08-19 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Ligand Recognition by the Lipid Transfer Domain of Human OSBP Is Important for Enterovirus Replication. Acs Infect Dis., 8, 2022
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5I6Q
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![BU of 5i6q by Molmil](/molmil-images/mine/5i6q) | Crystal structure of color device state B | 分子名称: | DNA (26-MER), DNA (5'-D(*AP*CP*AP*GP*TP*CP*GP*TP*GP*GP*TP*AP*TP*C)-3'), DNA (5'-D(*CP*AP*GP*AP*TP*AP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*TP*AP*CP*G)-3'), ... | 著者 | Hao, Y, Birktoft, J, Seeman, N.C. | 登録日 | 2016-02-16 | 公開日 | 2017-01-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (4.912 Å) | 主引用文献 | A device that operates within a self-assembled 3D DNA crystal. Nat Chem, 9, 2017
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8CPO
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![BU of 8cpo by Molmil](/molmil-images/mine/8cpo) | Crystal structure of the PolB16_OarG intein variant S1A, N183A, C111A, C165A | 分子名称: | PolB16 Intein Cys-less | 著者 | Kattelmann, S, Pasch, T, Mootz, H.D, Kuemmel, D. | 登録日 | 2023-03-03 | 公開日 | 2023-05-17 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins. Chem Sci, 14, 2023
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8CPN
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![BU of 8cpn by Molmil](/molmil-images/mine/8cpn) | Crystal structure of the PolB16_OarG intein variant S1A, N183A | 分子名称: | IODIDE ION, PolB16 intein | 著者 | Kattelmann, S, Pasch, T, Mootz, H.D, Kummel, D. | 登録日 | 2023-03-03 | 公開日 | 2023-05-17 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biochemical analysis of a novel atypically split intein reveals a conserved histidine specific to cysteine-less inteins. Chem Sci, 14, 2023
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5YJE
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![BU of 5yje by Molmil](/molmil-images/mine/5yje) | Crystal structure of HIRA(644-1017) | 分子名称: | Protein HIRA, SULFATE ION | 著者 | Sato, Y, Senda, M, Senda, T. | 登録日 | 2017-10-10 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit Nat Commun, 9, 2018
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5IWD
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![BU of 5iwd by Molmil](/molmil-images/mine/5iwd) | HCMV DNA polymerase subunit UL44 complex with a small molecule | 分子名称: | 5-methylidene-3-(methylsulfanyl)-2-benzothiophen-4(5H)-one, DNA polymerase processivity factor | 著者 | Chen, H, Coen, D.M, Hogle, J.M, Filman, D.J. | 登録日 | 2016-03-22 | 公開日 | 2016-11-30 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions. ACS Infect Dis, 3, 2017
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3SBD
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![BU of 3sbd by Molmil](/molmil-images/mine/3sbd) | Crystal structure of RAC1 P29S mutant | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1 | 著者 | Ha, B.H, Boggon, T.J. | 登録日 | 2011-06-03 | 公開日 | 2012-07-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat.Genet., 44, 2012
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