6C9V
| Mycobacterium tuberculosis adenosine kinase bound to (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | 分子名称: | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl]tetrahydrofuran-3,4-diol, Adenosine kinase, GLYCEROL, ... | 著者 | Crespo, R.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2018-01-28 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J.Med.Chem., 62, 2019
|
|
1G2I
| CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION | 分子名称: | PROTEASE I, SULFATE ION | 著者 | Du, X, Choi, I.-G, Kim, R, Jancarik, J, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | 登録日 | 2000-10-19 | 公開日 | 2000-11-08 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution. Proc.Natl.Acad.Sci.USA, 97, 2000
|
|
6C67
| Mycobacterium tuberculosis adenosine kinase bound to iodotubercidin | 分子名称: | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Adenosine kinase, GLYCEROL, ... | 著者 | Crespo, R.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2018-01-17 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J.Med.Chem., 62, 2019
|
|
5CA9
| |
6C9N
| |
5CA8
| |
2I47
| Crystal structure of catalytic domain of TACE with inhibitor | 分子名称: | 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE, ADAM 17, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... | 著者 | Xu, W, Condon, J.S, Lovering, F.E. | 登録日 | 2006-08-21 | 公開日 | 2006-12-05 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of potent and selective TACE inhibitors via the S1 pocket. Bioorg.Med.Chem.Lett., 17, 2007
|
|
6C9Q
| |
6C9R
| Mycobacterium tuberculosis adenosine kinase bound to (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-(thiophen-3-yl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | 分子名称: | 9-beta-D-ribofuranosyl-6-(thiophen-3-yl)-9H-purine, Adenosine kinase, GLYCEROL, ... | 著者 | Crespo, R.A, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2018-01-28 | 公開日 | 2019-05-01 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. J.Med.Chem., 62, 2019
|
|
8END
| |
8ENF
| |
8ENB
| |
5WI9
| Crystal structure of KL with an agonist Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 39F7 Fab heavy chain, ... | 著者 | Johnstone, S, Min, X, Wang, Z. | 登録日 | 2017-07-18 | 公開日 | 2018-07-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Agonistic beta-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions. J. Biol. Chem., 293, 2018
|
|
5ECE
| Tankyrase 1 with Phthalazinone 1 | 分子名称: | 1,2-ETHANEDIOL, 2-[4-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]phenyl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, ACETATE ION, ... | 著者 | Kazmirski, S.L, Johannes, J, Read, J.A, Howard, T, Larsen, N.A, Ferguson, A.D. | 登録日 | 2015-10-20 | 公開日 | 2015-11-25 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
|
|
6C9P
| |
5EBT
| Tankyrase 1 with Phthalazinone 2 | 分子名称: | (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one, Tankyrase-1, ... | 著者 | Kazmirski, S.L, Johannes, J. | 登録日 | 2015-10-19 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Bioorg.Med.Chem.Lett., 25, 2015
|
|
5F5M
| Crystal structure of Marburg virus nucleoprotein core domain | 分子名称: | Nucleoprotein | 著者 | Guo, Y, Liu, B.C, Liu, X, Li, G.B, Wang, W.M, Dong, S.S, Wang, W.J. | 登録日 | 2015-12-04 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | 主引用文献 | Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus J. Virol., 91, 2017
|
|
5F5O
| Crystal structure of Marburg virus nucleoprotein core domain bound to VP35 regulation peptide | 分子名称: | Nucleoprotein, Peptide from Polymerase cofactor VP35, SULFATE ION | 著者 | Guo, Y, Liu, B.C, Liu, X, Li, G.B, Wang, W.M, Dong, S.S, Wang, W.J. | 登録日 | 2015-12-04 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Insight into Nucleoprotein Conformation Change Chaperoned by VP35 Peptide in Marburg Virus J. Virol., 91, 2017
|
|
8JE2
| Cryo-EM structure of neddylated Cul2-Rbx1-EloBC-FEM1B complexed with FNIP1-FLCN | 分子名称: | Cullin-2, Elongin-B, Elongin-C, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-05-15 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
|
|
8JE1
| An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2 | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | 著者 | Dai, Z, Liang, L, Yin, Y.X. | 登録日 | 2023-05-15 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase. Embo J., 43, 2024
|
|
8H41
| Crystal structure of a decarboxylase from Trichosporon moniliiforme in complex with o-nitrophenol | 分子名称: | MAGNESIUM ION, O-NITROPHENOL, Salicylate decarboxylase | 著者 | Gao, J, Zhao, Y.P, Li, Q, Liu, W.D, Sheng, X. | 登録日 | 2022-10-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase Catalysts, 12, 2022
|
|
8ECZ
| Bovine Fab 4C1 | 分子名称: | 4C1 Fab heavy chain, 4C1 Fab light chain, PHOSPHATE ION | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8EDF
| |
8ECQ
| Bovine Fab 2G3 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2G3 Fab Heavy chain, 2G3 Fab Light chain, ... | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8ECV
| Bovine Fab 2F12 | 分子名称: | 2F12 Fab Heavy chain, 2F12 Fab Light chain | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|