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6B0N
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BU of 6b0n by Molmil
Crystal structure of the cleavage-independent prefusion HIV Env glycoprotein trimer of the clade A BG505 isolate (NFL construct) in complex with Fabs PGT122 and PGV19 at 3.39 A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp140, ...
著者Sarkar, A, Irimia, A, Wilson, I.A.
登録日2017-09-14
公開日2018-05-30
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer.
Nat Commun, 9, 2018
6BKB
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BU of 6bkb by Molmil
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab AR3A heavy chain, ...
著者Tzarum, N, Wilson, I.A, Law, M.
登録日2017-11-08
公開日2018-12-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.799 Å)
主引用文献Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKQ
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BU of 6bkq by Molmil
Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
6BKC
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Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab AR3B heavy chain, Fab AR3B light chain, ...
著者Tzarum, N, Wilson, I.A, Law, M.
登録日2017-11-08
公開日2018-12-26
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKO
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BU of 6bko by Molmil
Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin D190E mutant apo form
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
6BKS
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BU of 6bks by Molmil
Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin D190E mutant in complex with 6'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
6BL6
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BU of 6bl6 by Molmil
Crystallization of lipid A transporter MsbA from Salmonella typhimurium
分子名称: Lipid A export ATP-binding/permease protein MsbA
著者Padayatti, P.S, Stanfield, R.L, Zhang, Q, Wilson, I.A, Lee, S.C.
登録日2017-11-09
公開日2019-01-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights into the Lipid A Transport Pathway in MsbA.
Structure, 27, 2019
6BXC
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BU of 6bxc by Molmil
Crystal structure of N-terminal fragment of Zebrafish Toll-Like Receptor 5 (TLR5) with Lamprey Variable Lymphocyte Receptor 9 (VLR9) bound
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gunn, R.J, Wilson, I.A, Cooper, M.D, Herrin, B.R.
登録日2017-12-18
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.
J. Mol. Biol., 430, 2018
6CA9
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BU of 6ca9 by Molmil
Crystal structure of Fab PCT64_LMCA (SAR), the least mutated common ancestor of the HIV-1 broadly neutralizing antibody lineage PCT64
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, PCT64_LMCA Fab heavy chain, ...
著者Omorodion, O, Wilson, I.A.
登録日2018-01-29
公開日2018-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.702 Å)
主引用文献Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.
Cell Rep, 23, 2018
6CXL
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BU of 6cxl by Molmil
anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5
分子名称: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, anti-HIV-1 Fab 2G12 heavy chain, anti-HIV-1 Fab 2G12 light chain
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.586 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
6D2P
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BU of 6d2p by Molmil
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
分子名称: GLYCEROL, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, IOMAclass naive CLK31 Fab heavy chain, ...
著者Sarkar, A, Wilson, I.A.
登録日2018-04-13
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Sci Transl Med, 10, 2018
6CE0
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BU of 6ce0 by Molmil
Crystal structure of a HIV-1 clade B tier-3 isolate H078.14 UFO-BG Env trimer in complex with broadly neutralizing Fabs PGT124 and 35O22 at 4.6 Angstrom
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ...
著者Kumar, S, Sarkar, A, Wilson, I.A.
登録日2018-02-09
公開日2018-12-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.602 Å)
主引用文献HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
6CJK
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BU of 6cjk by Molmil
Anti HIV Fab 10A
分子名称: ACETATE ION, GLYCEROL, Immunoglobulin Fab heavy chain, ...
著者Hangartner, L, Ward, A.B, Wilson, I.A, Oyen, D.
登録日2018-02-26
公開日2018-08-15
最終更新日2019-12-18
実験手法X-RAY DIFFRACTION (1.795 Å)
主引用文献Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
6BXA
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BU of 6bxa by Molmil
Crystal structure of N-terminal fragment of Zebrafish Toll-Like Receptor 5 (TLR5) with Lamprey Variable Lymphocyte Receptor 2 (VLR2) bound
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Gunn, R.J, Wilson, I.A, Cooper, M.D, Herrin, B.R.
登録日2017-12-18
公開日2018-05-09
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.
J. Mol. Biol., 430, 2018
6CA7
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BU of 6ca7 by Molmil
Crystal structure of PCT64_13C, a strain specific anti-HIV antibody
分子名称: PCT64_13C heavy chain, PCT64_13C light chain
著者Murrell, S, Wilson, I.A.
登録日2018-01-29
公開日2018-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.643 Å)
主引用文献Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.
Cell Rep, 23, 2018
6CA6
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BU of 6ca6 by Molmil
Crystal structure of PCT64_35S, a broadly neutralizing anti-HIV antibody.
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, PCT64_35S heavy chain, ...
著者Murrell, S, Wilson, I.A.
登録日2018-01-29
公開日2018-06-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.
Cell Rep, 23, 2018
6CXG
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BU of 6cxg by Molmil
anti-HIV-1 Fab 2G12 in complex with glycopeptide 10V1S
分子名称: 10V1S glycopeptide, GLYCEROL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose, ...
著者Stanfield, R.L, Wilson, I.A.
登録日2018-04-03
公開日2019-02-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.
ACS Cent Sci, 5, 2019
6D0U
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BU of 6d0u by Molmil
Crystal structure of C05 V110P/A117E mutant bound to H3 influenza hemagglutinin, HA1 subunit
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 V110P/A117E mutant, heavy chain, ...
著者Wu, N.C, Wilson, I.A.
登録日2018-04-11
公開日2019-01-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Multistate design of influenza antibodies improves affinity and breadth against seasonal viruses.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CF7
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BU of 6cf7 by Molmil
Crystal structure of the A/Solomon Islands/3/2006(H1N1) influenza virus hemagglutinin in complex with small molecule JNJ4796
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Kadam, R.U, Wilson, I.A.
登録日2018-02-13
公開日2019-02-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.719 Å)
主引用文献A small-molecule fusion inhibitor of influenza virus is orally active in mice.
Science, 363, 2019
6BKR
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BU of 6bkr by Molmil
Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin in complex with 6'-SLN
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
著者Wu, N.C, Wilson, I.A.
登録日2017-11-09
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nat Commun, 9, 2018
6DCV
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BU of 6dcv by Molmil
Crystal structure of human anti-tau antibody CBTAU-27.1
分子名称: GLYCEROL, Light chain of CBTAU27.1 Fab, heavy chain of CBTAU-27.1 Fab
著者Zhu, X, Zhang, H, Wilson, I.A.
登録日2018-05-08
公開日2018-06-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Acta Neuropathol Commun, 6, 2018
4GMS
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BU of 4gms by Molmil
Crystal structure of heterosubtypic Fab S139/1 in complex with influenza A H3 hemagglutinin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab S139/1 heavy chain, ...
著者Lee, P.S, Ekiert, D.C, Wilson, I.A.
登録日2012-08-16
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GDI
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BU of 4gdi by Molmil
A subtype N10 neuraminidase-like protein of A/little yellow-shouldered bat/Guatemala/164/2009
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Zhu, X, Wilson, I.A.
登録日2012-07-31
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G6A
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BU of 4g6a by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33
分子名称: AP33 Heavy Chain, AP33 Light chain, E2 peptide
著者Kong, L, Wilson, I.A, Law, M.
登録日2012-07-18
公開日2012-09-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33.
J.Virol., 86, 2012
4GDJ
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BU of 4gdj by Molmil
A subtype N10 neuraminidase-like protein of A/little yellow-shouldered bat/Guatemala/060/2010
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neuraminidase, ...
著者Zhu, X, Wilson, I.A.
登録日2012-07-31
公開日2012-09-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site.
Proc.Natl.Acad.Sci.USA, 109, 2012

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