8YH9
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![BU of 8yh9 by Molmil](/molmil-images/mine/8yh9) | Type I-FHNH Cascade complex | 分子名称: | 60-nt crRNA, Cas5f, Cas6f, ... | 著者 | Li, Z. | 登録日 | 2024-02-27 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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8YEO
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![BU of 8yeo by Molmil](/molmil-images/mine/8yeo) | Type I-FHNH Cascade-dsDNA R-loop complex | 分子名称: | 60-nt crRNA, Cas5f, Cas6f, ... | 著者 | Li, Z. | 登録日 | 2024-02-22 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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7MN5
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![BU of 7mn5 by Molmil](/molmil-images/mine/7mn5) | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-10-27 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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7MN6
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![BU of 7mn6 by Molmil](/molmil-images/mine/7mn6) | Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-10-27 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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7MN8
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![BU of 7mn8 by Molmil](/molmil-images/mine/7mn8) | Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | 登録日 | 2021-04-30 | 公開日 | 2021-11-10 | 最終更新日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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2NSF
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![BU of 2nsf by Molmil](/molmil-images/mine/2nsf) | |
2NSG
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2EW7
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![BU of 2ew7 by Molmil](/molmil-images/mine/2ew7) | Crystal Structure of Helicobacter Pylori peptide deformylase | 分子名称: | COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
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2EW5
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![BU of 2ew5 by Molmil](/molmil-images/mine/2ew5) | Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor | 分子名称: | 4-{(1E)-3-OXO-3-[(2-PHENYLETHYL)AMINO]PROP-1-EN-1-YL}-1,2-PHENYLENE DIACETATE, COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
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2FOI
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![BU of 2foi by Molmil](/molmil-images/mine/2foi) | Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. | 分子名称: | 4-(2,4-DICHLOROPHENOXY)-2'-METHYLBIPHENYL-3-OL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, enoyl-acyl carrier reductase | 著者 | Freundlich, J.S, Shieh, H, Anderson, J.W, Kuo, M, Yu, M, Valderramos, J, Karagyozov, L, Tsai, H, Lucumi, E, Jacobs Jr, W.R, Schiehser, G.A, Jacobus, D.P, Fidock, D.A, Sacchettini, J.C. | 登録日 | 2006-01-13 | 公開日 | 2007-01-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy. J.Biol.Chem., 282, 2007
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2EW6
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![BU of 2ew6 by Molmil](/molmil-images/mine/2ew6) | Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor | 分子名称: | (2E)-3-(3,4-DIHYDROXYPHENYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]ACRYLAMIDE, COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
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4Q31
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![BU of 4q31 by Molmil](/molmil-images/mine/4q31) | The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FORMIC ACID, ... | 著者 | Tan, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-04-10 | 公開日 | 2014-05-07 | 最終更新日 | 2017-03-08 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. Struct Dyn, 3, 2016
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4MV2
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![BU of 4mv2 by Molmil](/molmil-images/mine/4mv2) | Crystal structure of plu4264 protein from Photorhabdus luminescens | 分子名称: | NICKEL (II) ION, SODIUM ION, plu4264 | 著者 | Michalska, K, Li, H, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R, Weerth, S, Thomas, M.G, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2013-09-23 | 公開日 | 2013-10-02 | 最終更新日 | 2015-02-04 | 実験手法 | X-RAY DIFFRACTION (1.349 Å) | 主引用文献 | Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 angstrom resolution. Proteins, 83, 2015
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7YDX
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![BU of 7ydx by Molmil](/molmil-images/mine/7ydx) | Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | 分子名称: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | 登録日 | 2022-07-04 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | 主引用文献 | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun, 13, 2022
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7YC9
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![BU of 7yc9 by Molmil](/molmil-images/mine/7yc9) | Co-crystal structure of BTK kinase domain with inhibitor | 分子名称: | (7~{S})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, Tyrosine-protein kinase BTK | 著者 | Zhou, X. | 登録日 | 2022-07-01 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J.Med.Chem., 66, 2023
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4FPW
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![BU of 4fpw by Molmil](/molmil-images/mine/4fpw) | Crystal Structure of CalU16 from Micromonospora echinospora. Northeast Structural Genomics Consortium Target MiR12. | 分子名称: | CalU16 | 著者 | Seetharaman, J, Lew, S, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Phillips Jr, G.N, Kennedy, M.A, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-06-22 | 公開日 | 2012-12-12 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19. Acs Chem.Biol., 9, 2014
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4EAX
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![BU of 4eax by Molmil](/molmil-images/mine/4eax) | Mouse NGF in complex with Lyso-PS | 分子名称: | Beta-nerve growth factor, O-[(S)-hydroxy{[(2S)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-L-serine | 著者 | Jiang, T, Tong, Q. | 登録日 | 2012-03-23 | 公開日 | 2012-09-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional insights into lipid-bound nerve growth factors Faseb J., 26, 2012
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5H48
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![BU of 5h48 by Molmil](/molmil-images/mine/5h48) | Crystal structure of Cbln1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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5H4C
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![BU of 5h4c by Molmil](/molmil-images/mine/5h4c) | Crystal structure of Cbln4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein Cbln4 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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7VS2
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4M6W
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![BU of 4m6w by Molmil](/molmil-images/mine/4m6w) | Crystal structure of the C-terminal segment of FANCM in complex with FAAP24 | 分子名称: | Fanconi anemia group M protein, Fanconi anemia-associated protein of 24 kDa, SULFATE ION | 著者 | Yang, H, Zhang, T, Tong, L, Ding, J. | 登録日 | 2013-08-11 | 公開日 | 2013-10-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res., 41, 2013
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5H49
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![BU of 5h49 by Molmil](/molmil-images/mine/5h49) | Crystal structure of Cbln1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cerebellin-1 | 著者 | Zhong, C, Shen, J, Zhang, H, Ding, J. | 登録日 | 2016-10-31 | 公開日 | 2017-09-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Cbln1 and Cbln4 Are Structurally Similar but Differ in GluD2 Binding Interactions. Cell Rep, 20, 2017
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5XLB
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5XL2
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5XLD
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![BU of 5xld by Molmil](/molmil-images/mine/5xld) | |