3PS0
 
 | | The structure of the CRISPR-associated protein, csa2, from Sulfolobus solfataricus | | 分子名称: | CRISPR-Associated protein, CSA2 | | 著者 | Lintner, N.G, Sdano, M, Young, M.J, Lawrence, C.M. | | 登録日 | 2010-11-30 | | 公開日 | 2011-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and functional characterization of an archaeal clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for antiviral defense (CASCADE).
J.Biol.Chem., 286, 2011
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3PV1
 | | Crystal structure of the USP15 DUSP-UBL domains | | 分子名称: | ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 15 | | 著者 | Elliott, P.R, Urbe, S, Clague, M.J, Barsukov, I.L. | | 登録日 | 2010-12-06 | | 公開日 | 2011-11-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural variability of the ubiquitin specific protease DUSP-UBL double domains.
Febs Lett., 585, 2011
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4YSB
 | | Crystal structure of ETHE1 from Myxococcus xanthus | | 分子名称: | FE (III) ION, Metallo-beta-lactamase family protein | | 著者 | Sattler, S.A, Wang, X, DeHan, P.J, Xun, L, Kang, C. | | 登録日 | 2015-03-17 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5015 Å) | | 主引用文献 | Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
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4YSK
 | | Crystal structure of apo-form SdoA from Pseudomonas putida | | 分子名称: | Beta-lactamase domain protein, FE (III) ION | | 著者 | Sattler, S.A, Wang, X, DeHan, P.J, Xun, L, Kang, C. | | 登録日 | 2015-03-17 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.466 Å) | | 主引用文献 | Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
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4YSL
 | | Crystal structure of SdoA from Pseudomonas putida in complex with glutathione | | 分子名称: | Beta-lactamase domain protein, FE (III) ION, GLUTATHIONE | | 著者 | Sattler, S.A, Wang, X, DeHan, P.J, Xun, L, Kang, C. | | 登録日 | 2015-03-17 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.4618 Å) | | 主引用文献 | Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-beta-lactamase Superfamily.
J.Biol.Chem., 290, 2015
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7KS6
 | | STRUCTURE OF TETRASACCHARIDE BUILDING BLOCK OF A SULFATED FUCAN FROM LYTECHINUS VARIEGATUS | | 分子名称: | 4-O-sulfo-alpha-L-fucopyranose-(1-3)-2,4-di-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose | | 著者 | Kim, S.B, Thara, R, Aderibigbe, A.O, Doerksen, R.J, Pomin, V.H. | | 登録日 | 2020-11-21 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational properties of l-fucose and the tetrasaccharide building block of the sulfated l-fucan from Lytechinus variegatus.
J.Struct.Biol., 209, 2020
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8I8Y
 | | A mutant of the C-terminal complex of proteins 4.1G and NuMA | | 分子名称: | Engineered protein | | 著者 | Hu, X. | | 登録日 | 2023-02-06 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7W0G
 | | Human PPAR delta ligand binding domain in complex with a synthetic agonist H11 | | 分子名称: | 2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta | | 著者 | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | | 登録日 | 2021-11-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.443 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR alpha / delta Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.
J.Med.Chem., 65, 2022
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5W5J
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7LJE
 | | Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases | | 分子名称: | 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide, Histone acetyltransferase p300 | | 著者 | Jakob, C.G. | | 登録日 | 2021-01-29 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.607 Å) | | 主引用文献 | Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.
Bioorg.Med.Chem.Lett., 39, 2021
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8JPA
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5DH3
 | | Crystal structure of MST2 in complex with XMU-MP-1 | | 分子名称: | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, CHLORIDE ION, SULFATE ION, ... | | 著者 | Kong, L.L, Yun, C.H. | | 登録日 | 2015-08-29 | | 公開日 | 2016-08-31 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.468 Å) | | 主引用文献 | Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
Sci Transl Med, 8, 2016
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2JVN
 | | Domain C of human PARP-1 | | 分子名称: | Poly [ADP-ribose] polymerase 1, ZINC ION | | 著者 | Hoffman, D, Tao, Z, Liu, H. | | 登録日 | 2007-09-24 | | 公開日 | 2008-05-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif.
Biochemistry, 47, 2008
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4EXB
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4ETR
 | | X-ray structure of PA2169 from Pseudomonas aeruginosa | | 分子名称: | Putative uncharacterized protein | | 著者 | Schnell, R, Sandalova, T, Lindqvist, Y, Schneider, G. | | 登録日 | 2012-04-24 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Acta Crystallogr.,Sect.F, 69, 2013
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4ES6
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7N3U
 | | Crystal structure of human WEE1 kinase domain in complex with ZN-c3 | | 分子名称: | 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, Wee1-like protein kinase | | 著者 | Lee, C.C. | | 登録日 | 2021-06-02 | | 公開日 | 2021-09-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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5XEG
 | | The structure of OsALKBH1 | | 分子名称: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, Oxidoreductase, ... | | 著者 | Wang, C, Guo, Y, Zeng, Z. | | 登録日 | 2017-04-05 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification and analysis of adenine N6-methylation sites in the rice genome.
Nat Plants, 4, 2018
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5W5O
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4EXA
 | | Crystal structure of the PA4992, the putative aldo-keto reductase from Pseudomona aeruginosa | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative uncharacterized protein | | 著者 | Sandalova, T, Schnell, R, Schneider, G. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery.
Acta Crystallogr.,Sect.F, 69, 2013
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5XOI
 | | The structure of OsALKBH1 | | 分子名称: | MANGANESE (II) ION, Oxidoreductase, 2OG-Fe oxygenase family protein, ... | | 著者 | Wang, C, Guo, Y, Zeng, Z. | | 登録日 | 2017-05-28 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identification and analysis of adenine N6-methylation sites in the rice genome.
Nat Plants, 4, 2018
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2LWS
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2M0Q
 | | Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix | | 分子名称: | Potassium voltage-gated channel subfamily E member 2 | | 著者 | Lai, C, Li, P, Chen, L, Zhang, L, Wu, F, Tian, C. | | 登録日 | 2012-11-01 | | 公開日 | 2014-04-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Differential modulations of KCNQ1 by auxiliary proteins KCNE1 and KCNE2.
Sci Rep, 4, 2014
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2LWU
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6AI9
 | | Cab2 mutant-H337A complex with phosphopantothenate | | 分子名称: | N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanine, Phosphopantothenate--cysteine ligase CAB2 | | 著者 | Zheng, P, Zhu, Z. | | 登録日 | 2018-08-22 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
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