7W0G
Human PPAR delta ligand binding domain in complex with a synthetic agonist H11
Summary for 7W0G
Entry DOI | 10.2210/pdb7w0g/pdb |
Descriptor | Peroxisome proliferator-activated receptor delta, 2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid (3 entities in total) |
Functional Keywords | complex, agonist, peroxisome proliferator-activated receptor, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65652.04 |
Authors | Dai, L.,Sun, H.B.,Yuan, H.L.,Feng, Z.Q. (deposition date: 2021-11-18, release date: 2022-02-02, Last modification date: 2024-05-29) |
Primary citation | Feng, Z.,Xiang, J.,Liu, H.,Li, J.,Xu, X.,Sun, G.,Zheng, R.,Zhang, S.,Liu, J.,Yang, S.,Xu, Q.,Wen, X.,Yuan, H.,Sun, H.,Dai, L. Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR alpha / delta Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J.Med.Chem., 65:2571-2592, 2022 Cited by PubMed: 35060744DOI: 10.1021/acs.jmedchem.1c02002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.443 Å) |
Structure validation
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