7W0G

Human PPAR delta ligand binding domain in complex with a synthetic agonist H11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Peroxisome proliferator-activated receptor delta	polymer	282	32360.6	2	UniProt (Q03181) Pfam (PF00104) In PDB	Homo sapiens (Human)	PPAR-delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta
2	A, B	2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic acid	non-polymer		465.4	2	Chemie (85B)
3		water	water		18.0	18	Chemie (HOH)

Sequence modifications

A, B: 173 - 441 (UniProt: Q03181)

PDB	External Database	Details
Met 160	-	initiating methionine
His 161	-	expression tag
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
Leu 167	-	expression tag
Val 168	-	expression tag
Pro 169	-	expression tag
Arg 170	-	expression tag
Gly 171	-	expression tag
Ser 172	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64721.2
Non-Polymers*	Number of molecules	2
	Total formula weight	930.8
All*	Total formula weight	65652.0

*Water molecules are not included.