7FGW
 
 | | Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, BENZAMIDINE, ... | | 著者 | Vanichtanankul, J, Yoomuang, A, Taweechai, S, Saeyang, T, Yuvaniyama, Y, Tarnchompoo, B, Yuthavong, Y, Kamchonwongpaisan, S. | | 登録日 | 2021-07-28 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase.
Acs Chem.Biol., 17, 2022
|
|
4NIE
 | |
6INH
 | | A glycosyltransferase with UDP and the substrate | | 分子名称: | 1-O-[(8alpha,9beta,10alpha,13alpha)-13-(beta-D-glucopyranosyloxy)-18-oxokaur-16-en-18-yl]-beta-D-glucopyranose, GLYCEROL, UDP-glycosyltransferase 76G1, ... | | 著者 | Zhu, X. | | 登録日 | 2018-10-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Hydrophobic recognition allows the glycosyltransferase UGT76G1 to catalyze its substrate in two orientations.
Nat Commun, 10, 2019
|
|
6ING
 | |
6KJY
 | | Galectin-13 variant C136S/C138S | | 分子名称: | Galactoside-binding soluble lectin 13 | | 著者 | Su, J. | | 登録日 | 2019-07-23 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
Glycobiology, 30, 2020
|
|
6KJW
 | | Galectin-13 variant C136S | | 分子名称: | Galactoside-binding soluble lectin 13 | | 著者 | Su, J. | | 登録日 | 2019-07-23 | | 公開日 | 2019-10-16 | | 最終更新日 | 2020-02-19 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
Glycobiology, 30, 2020
|
|
6KJX
 | | Galectin-13 variant C138S | | 分子名称: | Galactoside-binding soluble lectin 13 | | 著者 | Su, J. | | 登録日 | 2019-07-23 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
Glycobiology, 30, 2020
|
|
7FIC
 | |
7XPN
 | |
2QT0
 | | Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside and an ATP analogue | | 分子名称: | MAGNESIUM ION, Nicotinamide riboside, Nicotinamide riboside kinase 1, ... | | 著者 | Rabeh, W.M, Tempel, W, Nedyalkova, L, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Brenner, C, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2007-07-31 | | 公開日 | 2007-08-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+).
Plos Biol., 5, 2007
|
|
6U09
 | |
6U06
 | |
8D1G
 | | hBest2 Ca2+-bound open state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.07 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1O
 | | hBest1_345 Ca2+-bound open state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1I
 | | hBest1 1uM Ca2+ (Ca2+-bound) closed state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (1.82 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1K
 | | hBest1 Ca2+-bound partially open neck state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1F
 | | hBest2 5mM Ca2+ (Ca2+-bound) closed state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (1.82 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1N
 | | bBest2_345 Ca2+-bound open state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (1.93 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1E
 | | hBest2 1uM Ca2+ (Ca2+-bound) closed state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (1.78 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1J
 | | hBest1 5mM Ca2+ (Ca2+-bound) closed state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.05 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1L
 | | hBest1 Ca2+-bound partially open aperture state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (2.12 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8D1M
 | |
8D1H
 | | hBest2 Ca2+-unbound closed state | | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | | 登録日 | 2022-05-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (1.94 Å) | | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels.
Nat Commun, 13, 2022
|
|
8YLB
 | | Cocrystal structures of agonists compound 1 with HsClpP | | 分子名称: | 5-[(2-methylphenyl)methyl]-11-(phenylmethyl)-2,5,7,11-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),6-dien-8-one, ATP-dependent Clp protease proteolytic subunit, mitochondrial | | 著者 | Zhao, N, Zhu, Y, Bao, R. | | 登録日 | 2024-03-06 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Rational Design of a Novel Class of Human ClpP Agonists through a Ring-Opening Strategy with Enhanced Antileukemia Activity.
J.Med.Chem., 67, 2024
|
|
4XT9
 | | RORgamma (263-509) complexed with GSK2435341A and SRC2 | | 分子名称: | LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, N-[4-(2,5-dichlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... | | 著者 | Wang, Y, Ma, Y. | | 登録日 | 2015-01-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR gamma t inverse agonists
Bioorg.Med.Chem., 23, 2015
|
|
