7FGW
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP
Summary for 7FGW
Entry DOI | 10.2210/pdb7fgw/pdb |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total) |
Functional Keywords | pyrimethamine, toxoplasma gondii, dihydrofolate reductase, thymidylate synthase, oxidoreductase |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 4 |
Total formula weight | 280820.18 |
Authors | Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Yuvaniyama, Y.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. (deposition date: 2021-07-28, release date: 2022-06-29, Last modification date: 2023-11-29) |
Primary citation | Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Pengon, J.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17:1691-1702, 2022 Cited by PubMed: 35715223DOI: 10.1021/acschembio.1c00627 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)