7FGW

Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP

Summary for 7FGW

Entry DOI	10.2210/pdb7fgw/pdb
Descriptor	Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... (6 entities in total)
Functional Keywords	pyrimethamine, toxoplasma gondii, dihydrofolate reductase, thymidylate synthase, oxidoreductase
Biological source	Toxoplasma gondii
Total number of polymer chains	4
Total formula weight	280820.18
Authors	Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Yuvaniyama, Y.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. (deposition date: 2021-07-28, release date: 2022-06-29, Last modification date: 2023-11-29)
Primary citation	Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Pengon, J.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17:1691-1702, 2022 Cited by PubMed: 35715223 DOI: 10.1021/acschembio.1c00627 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation