7FGW

Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with pyrimethamine, NADPH and dUMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Bifunctional dihydrofolate reductase-thymidylate synthase	polymer	610	68842.7	4	UniProt (Q07422) Pfam (PF00186) Pfam (PF00303)	Toxoplasma gondii	DHFR-TS
2	E, I, L, P (A, B, C, D)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)
3	F, J, M, Q (A, B, C, D)	5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE	non-polymer		248.7	4	Chemie (CP6)
4	G, N (A, C)	BENZAMIDINE	non-polymer		120.2	2	Chemie (BEN)
5	H, K, O, R (A, B, C, D)	2'-DEOXYURIDINE 5'-MONOPHOSPHATE	non-polymer		308.2	4	Chemie (UMP)
6	S, T, U, V (A, B, C, D)	water	water		18.0	1531	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	275370.6
Non-Polymers*	Number of molecules	14
	Total formula weight	5449.6
All*	Total formula weight	280820.2

*Water molecules are not included.