7SZL
 
 | | Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2) | | 分子名称: | X-linked interleukin-1 receptor accessory protein-like 2 | | 著者 | Nimma, S, Gu, W, Manik, M.K, Ve, T, Nanson, J.D, Kobe, B. | | 登録日 | 2021-11-28 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signalling.
Febs Lett., 596, 2022
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4C0M
 | | Crystal Structure of the N terminal domain of wild type TRIF (TIR- domain-containing adapter-inducing interferon-beta) | | 分子名称: | TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 | | 著者 | Ullah, M.O, Ve, T, Mangan, M, Alaidarous, M, Sweet, M.J, Mansell, A, Kobe, B. | | 登録日 | 2013-08-05 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Tlr Signalling Adaptor Trif/Ticam-1 Has an N-Terminal Helical Domain with Structural Similarity to Ifit Proteins
Acta Crystallogr.,Sect.D, 69, 2013
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4C7M
 | | The crystal structure of TcpB or BtpA TIR domain | | 分子名称: | Toll/interleukin-1 receptor domain-containing protein | | 著者 | Alaidarous, M, Ve, T, Casey, L.W, Valkov, E, Ullah, M.O, Schembri, M.A, Mansell, A, Sweet, M.J, Kobe, B. | | 登録日 | 2013-09-23 | | 公開日 | 2013-12-04 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.
J.Biol.Chem., 289, 2014
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4BSX
 | | Crystal Structure of the N terminal domain of TRIF (TIR-domain- containing adapter-inducing interferon-beta) | | 分子名称: | TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1 | | 著者 | Ullah, M.O, Ve, T, Mangan, M, Alaidarous, M, Sweet, M.J, Mansell, A, Kobe, B. | | 登録日 | 2013-06-12 | | 公開日 | 2013-12-11 | | 最終更新日 | 2013-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.229 Å) | | 主引用文献 | The Tlr Signalling Adaptor Trif/Ticam-1 Has an N-Terminal Helical Domain with Structural Similarity to Ifit Proteins
Acta Crystallogr.,Sect.D, 69, 2013
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4BZ4
 | | CorA is a surface-associated copper-binding protein important in Methylomicrobium album BG8 copper acquisition | | 分子名称: | CALCIUM ION, COPPER (I) ION, COPPER-REPRESSIBLE POLYPEPTIDE, ... | | 著者 | Johnson, K.A, Ve, T, Pedersen, R.B, Lillehaug, J.R, Jensen, H.B, Helland, R, Karlsen, O.A. | | 登録日 | 2013-07-24 | | 公開日 | 2014-02-19 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Cora is a Copper Repressible Surface-Associated Copper(I)-Binding Protein Produced in Methylomicrobium Album Bg8.
Plos One, 9, 2014
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6C0M
 | | The synthesis, biological evaluation and structural insights of unsaturated 3-N-substituted sialic acids as probes of human parainfluenza virus-3 haemagglutinin-neuraminidase | | 分子名称: | 1,2-ETHANEDIOL, 2,6-anhydro-3,5-dideoxy-5-[(2-methylpropanoyl)amino]-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-D-glycero-D-galacto-non-2-enoni c acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Dirr, L, Ve, T, von Itzstein, M. | | 登録日 | 2018-01-01 | | 公開日 | 2018-06-27 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes.
ACS Chem. Biol., 13, 2018
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6BR5
 | | N2 neuraminidase in complex with a novel antiviral compound | | 分子名称: | (1R)-4-acetamido-1,5-anhydro-3-carbamimidamido-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. | | 登録日 | 2017-11-30 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.0379076 Å) | | 主引用文献 | A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity.
ChemMedChem, 13, 2018
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6BR6
 | | N2 neuraminidase in complex with a novel antiviral compound | | 分子名称: | (1R)-4-acetamido-3-amino-1,5-anhydro-2,3,4-trideoxy-1-sulfo-D-glycero-D-galacto-octitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Li, L.H, Ve, T, Pascolutti, M, Hadhazi, A, Bailly, B, Thomson, R.J, Gao, G.F, von Itzstein, M. | | 登録日 | 2017-11-30 | | 公開日 | 2018-03-07 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.03983879 Å) | | 主引用文献 | A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity.
ChemMedChem, 13, 2018
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7L6W
 | | SFX structure of the MyD88 TIR domain higher-order assembly | | 分子名称: | Myeloid differentiation primary response protein MyD88 | | 著者 | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Flueckiger, L, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Stacey, K.J, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | 登録日 | 2020-12-24 | | 公開日 | 2021-03-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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7RTC
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7BER
 | | SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly) | | 分子名称: | Myeloid differentiation primary response protein MyD88 | | 著者 | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | 登録日 | 2020-12-24 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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7BEQ
 | | MicroED structure of the MyD88 TIR domain higher-order assembly | | 分子名称: | Myeloid differentiation primary response protein MyD88 | | 著者 | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | 登録日 | 2020-12-24 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3 Å) | | 主引用文献 | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
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6WEB
 | | Multi-Hit SFX using MHz XFEL sources | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Holmes, S, Darmanin, C, Abbey, B. | | 登録日 | 2020-04-01 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
Nat Commun, 13, 2022
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6WEC
 | | Multi-Hit SFX using MHz XFEL sources | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Holmes, S, Darmanin, C, Abbey, B. | | 登録日 | 2020-04-01 | | 公開日 | 2021-10-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
Nat Commun, 13, 2022
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7SHJ
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6GTH
 | | Serial Femtosecond Crystallography at Megahertz pulse rates | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | | 著者 | Wiedorn, M, Oberthuer, D, Werner, N, Schubert, R, White, T.A, Mancuso, A, Perbandt, M, Betzel, C, Barty, A, Chapman, H. | | 登録日 | 2018-06-18 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Megahertz serial crystallography.
Nat Commun, 9, 2018
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6FTR
 | | Serial Femtosecond Crystallography at Megahertz pulse rates | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Wiedorn, M.O, Oberthuer, D, Barty, A, Chapman, H.N. | | 登録日 | 2018-02-23 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.76000106 Å) | | 主引用文献 | Megahertz serial crystallography.
Nat Commun, 9, 2018
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7TUM
 | | Multi-Hit SFX using MHz XFEL sources- first hit | | 分子名称: | 1,2-ETHANEDIOL, Lysozyme C, SODIUM ION | | 著者 | Darmanin, C, Holmes, S, Abbey, B. | | 登録日 | 2022-02-03 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.202 Å) | | 主引用文献 | Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
Nat Commun, 13, 2022
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8F73
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2NDH
 | | NMR solution structure of MAL/TIRAP TIR domain (C116A) | | 分子名称: | Toll/interleukin-1 receptor domain-containing adapter protein | | 著者 | Lavrencic, P, Mobli, M. | | 登録日 | 2016-05-27 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TEB
 | | Crystal Structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPP1 | | 分子名称: | Recognition of Peronospora parasitica 1 | | 著者 | Bentham, A.R, Zhang, X, Croll, T, Williams, S, Kobe, B. | | 登録日 | 2016-09-20 | | 公開日 | 2017-02-01 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | | 主引用文献 | Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6OGD
 | | Cryo-EM structure of YenTcA in its prepore state | | 分子名称: | Chitinase 2, Toxin subunit YenA1, Toxin subunit YenA2 | | 著者 | Piper, S.J, Brillault, L, Box, J.K, Landsberg, M.J. | | 登録日 | 2019-04-02 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.
Nat Commun, 10, 2019
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5VJJ
 | | Crystal structure of the flax-rust effector AvrP | | 分子名称: | Avirulence protein AvrP123, ZINC ION | | 著者 | Zhang, X, Ericsson, D.J, Williams, S.J, Kobe, B. | | 登録日 | 2017-04-19 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.
Mol. Plant Pathol., 19, 2018
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8JZM
 | | The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210 | | 分子名称: | Toll/interleukin-1 receptor domain-containing adapter protein | | 著者 | Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B. | | 登録日 | 2023-07-05 | | 公開日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem, 39, 2024
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7M6K
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