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Structure of human TIRR in complex with 53BP1 Tudor domains
分子名称:	TP53-binding protein 1, Tudor-interacting repair regulator protein
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2018-03-10
公開日	2018-06-06
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.179 Å)
主引用文献	Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018

6CO2

Structure of an engineered protein (NUDT16TI) in complex with 53BP1 Tudor domains
分子名称:	NUDT16-Tudor-interacting (NUDT16TI), TP53-binding protein 1
著者	Botuyan, M.V, Thompson, J.R, Cui, G, Mer, G.
登録日	2018-03-10
公開日	2018-06-06
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (2.49 Å)
主引用文献	Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018

6D0L

Structure of human TIRR
分子名称:	Tudor-interacting repair regulator protein
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2018-04-10
公開日	2018-06-06
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.97 Å)
主引用文献	Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018

8U4U

Crystal structure of 53BP1 tandem Tudor domain homodimer engineered with two disulfide bridges
分子名称:	TP53-binding protein 1
著者	Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日	2023-09-11
公開日	2023-09-20
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (3.79 Å)
主引用文献	An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14, 2023

3P8D

Crystal structure of the second Tudor domain of human PHF20 (homodimer form)
分子名称:	Medulloblastoma antigen MU-MB-50.72
著者	Cui, G, Lee, J, Thompson, J.R, Botuyan, M.V, Mer, G.
登録日	2010-10-13
公開日	2011-06-22
最終更新日	2012-09-26
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat.Struct.Mol.Biol., 19, 2012

8UQ9

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker
分子名称:	CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ...
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQ8

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker
分子名称:	CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ...
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.34 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQA

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker
分子名称:	CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ...
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.049 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQC

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2)
分子名称:	E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.61 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQB

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1)
分子名称:	CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.484 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQD

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density)
分子名称:	E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (3.893 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

8UQE

Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 26-residue linker (RING not modeled in density)
分子名称:	E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2023-10-23
公開日	2024-01-17
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (3.562 Å)
主引用文献	Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024

3PD7

Crystal Structure of the Sixth BRCT Domain of Human TopBP1
分子名称:	DNA topoisomerase 2-binding protein 1
著者	Lee, J, Xu, C, Cui, G, Thompson, J.R, Mer, G.
登録日	2010-10-22
公開日	2010-12-08
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.26 Å)
主引用文献	Crystal Structure of the Sixth BRCT Domain of Human TopBP1 To be Published

6VE5

X-ray structure of human REV7 in complex with Shieldin3 (residues 41-74)
分子名称:	Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2019-12-28
公開日	2021-01-13
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta. J.Biol.Chem., 297, 2021

3SD4

Crystal structure of the first Tudor domain of human PHF20
分子名称:	PHD finger protein 20
著者	Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日	2011-06-08
公開日	2011-06-22
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.928 Å)
主引用文献	PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat.Struct.Mol.Biol., 19, 2012

5VX7

Solution NMR structure of the BRCT domain of S. cerevisiae Rev1
分子名称:	DNA repair protein REV1
著者	Xu, C, Cui, G, Botuyan, M.V, Mer, G.
登録日	2017-05-23
公開日	2018-01-31
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Solution NMR structure of the BRCT domain of S. cerevisiae Rev1 To Be Published

5VEY

Solution NMR structure of histone H2A-H2B mono-ubiquitylated at H2A Lys15 in complex with RNF169 (653-708)
分子名称:	E3 ubiquitin-protein ligase RNF169, Histone H2B type 1-J,Histone H2A type 1-B/E, Polyubiquitin-B
著者	Hu, Q, Botuyan, M.V, Cui, G, Mer, G.
登録日	2017-04-06
公開日	2017-05-17
最終更新日	2022-02-23
実験手法	SOLUTION NMR
主引用文献	Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18. Mol. Cell, 66, 2017

5VZM

Solution NMR structure of human Rev1 (932-1039) in complex with ubiquitin
分子名称:	DNA repair protein REV1, Ubiquitin
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2017-05-29
公開日	2018-05-23
最終更新日	2019-12-04
実験手法	SOLUTION NMR
主引用文献	Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin. J. Mol. Biol., 430, 2018

5UMV

Crystal structure of the BRCT domain of S. cerevisiae Rev1
分子名称:	DNA repair protein REV1
著者	Lee, J, Xu, C, Thompson, J.R, Botuyan, M.V, Mer, G.
登録日	2017-01-29
公開日	2018-01-31
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Crystal structure of the BRCT domain of S. cerevisiae Rev1 To Be Published

5VF0

Solution NMR structure of human RAD18 (198-240) in complex with ubiquitin
分子名称:	E3 ubiquitin-protein ligase RAD18, Polyubiquitin-B, ZINC ION
著者	Hu, Q, Botuyan, M.V, Mer, G.
登録日	2017-04-06
公開日	2017-05-17
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18. Mol. Cell, 66, 2017

2LH0

NMR structure of the histone-interacting N-terminal homodimeric region of Rtt106
分子名称:	Histone chaperone RTT106
著者	Hu, Q, Cui, G, Mer, G.
登録日	2011-08-04
公開日	2012-02-01
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106. Nature, 483, 2012

2LVM

Solution structure of human 53BP1 tandem Tudor domains in complex with a histone H4K20me2 peptide
分子名称:	Histone H4, Tumor suppressor p53-binding protein 1
著者	Cui, G, Botuyan, M, Mer, G.
登録日	2012-07-07
公開日	2012-12-12
最終更新日	2013-04-03
実験手法	SOLUTION NMR
主引用文献	Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat.Struct.Mol.Biol., 20, 2013

2LY1

NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #2)
分子名称:	Tudor domain-containing protein 7
著者	Cui, G, Botuyan, M, Mer, G.
登録日	2012-09-10
公開日	2013-09-11
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	NMR structure of the second and third lotus domains of tudor domain-containing protein 7 To be Published

2MWO

Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide
分子名称:	Cellular tumor antigen p53, Tumor suppressor p53-binding protein 1
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2014-11-15
公開日	2014-12-10
最終更新日	2015-03-18
実験手法	SOLUTION NMR
主引用文献	Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1. Structure, 23, 2015

2MWP

Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
分子名称:	Cellular tumor antigen p53, Tumor suppressor p53-binding protein 1
著者	Cui, G, Botuyan, M.V, Mer, G.
登録日	2014-11-15
公開日	2014-12-10
最終更新日	2015-03-18
実験手法	SOLUTION NMR
主引用文献	Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1. Structure, 23, 2015

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