7FIL
| |
7FIK
| The cryo-EM structure of the CR subunit from X. laevis NPC | 分子名称: | MGC154553 protein, MGC83295 protein, MGC83926 protein, ... | 著者 | Shi, Y, Huang, G, Zhan, X. | 登録日 | 2021-07-31 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex. Science, 376, 2022
|
|
6TGE
| |
8S9B
| Cryo-EM structure of Nav1.7 with LCM | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8S9C
| Cryo-EM structure of Nav1.7 with CBZ | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-03-27 | 公開日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
6A72
| Copper transporter protein | 分子名称: | ATP7B protein, CALCIUM ION, dioxo(di-mu-sulfide)dimolybdenum | 著者 | Chen, W.B. | 登録日 | 2018-07-01 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein. Nat Commun, 10, 2019
|
|
6JI0
| Structure of RyR2 (F/A/C/Ca2+ dataset) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | 登録日 | 2019-02-19 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
|
|
6JGZ
| Structure of RyR2 (F/P/Ca2+ dataset) | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1B, RyR2, ZINC ION | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | 登録日 | 2019-02-16 | 公開日 | 2019-12-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6JIY
| Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | 登録日 | 2019-02-24 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
|
|
6JG3
| Cryo-EM structure of RyR2 (Ca2+ alone dataset) | 分子名称: | Ryanodine receptor 2, ZINC ION | 著者 | Chi, X.M, Gong, D.S, Ren, K, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Zhou, Q, Yan, N. | 登録日 | 2019-02-13 | 公開日 | 2019-12-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6JRS
| Structure of RyR2 (*F/A/C/L-Ca2+/Ca2+-CaM dataset) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | 登録日 | 2019-04-05 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
|
|
6JV2
| Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset) | 分子名称: | CALCIUM ION, Calmodulin-1, RyR2, ... | 著者 | Gong, D.S, Chi, X.M, Zhou, G.W, Huang, G.X.Y, Lei, J.L, Yan, N. | 登録日 | 2019-04-15 | 公開日 | 2019-07-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 572, 2019
|
|
8WGH
| Cryo-EM structure of the red-shifted Fittonia albivenis PSI-LHCI | 分子名称: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Huang, G.Q, Li, X.X, Sui, S.F, Qin, X.C. | 登録日 | 2023-09-21 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structure of the red-shifted Fittonia albivenis photosystem I. Nat Commun, 15, 2024
|
|
8Y66
| Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin | 分子名称: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Solute carrier family 2, facilitated glucose transporter member 9 | 著者 | Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y. | 登録日 | 2024-02-01 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nat Commun, 15, 2024
|
|
8Y65
| Cryo-EM structure of human urate transporter GLUT9 bound to substrate urate | 分子名称: | Solute carrier family 2, facilitated glucose transporter member 9, URIC ACID | 著者 | Pan, X.J, Shen, Z.L, Xu, L, Huang, G.X.Y. | 登録日 | 2024-02-01 | 公開日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structural basis for urate recognition and apigenin inhibition of human GLUT9. Nat Commun, 15, 2024
|
|
6A69
| Cryo-EM structure of a P-type ATPase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuroplastin, Plasma membrane calcium-transporting ATPase 1 | 著者 | Gong, D.S, Chi, X.M, Ren, K, Huang, G.X.Y, Zhou, G.W, Yan, N, Lei, J.L, Zhou, Q. | 登録日 | 2018-06-27 | 公開日 | 2018-09-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.11 Å) | 主引用文献 | Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin. Nat Commun, 9, 2018
|
|
8FHS
| Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at 3.3 Angstrom resolution | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-12-15 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
|
|
6LY5
| Organization and energy transfer in a huge diatom PSI-FCPI supercomplex | 分子名称: | (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, (3S,3'S,5R,5'R,6S,6'R,8'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'- yl acetate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | 著者 | Xiong, P, Caizhe, X. | 登録日 | 2020-02-13 | 公開日 | 2020-10-21 | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | 主引用文献 | Structural basis for energy transfer in a huge diatom PSI-FCPI supercomplex. Nat Commun, 11, 2020
|
|
3WSA
| The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole | 分子名称: | N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, Squalene synthase | 著者 | Shang, N, Li, Q, Huang, C.H, Oldfield, E, Guo, R.T. | 登録日 | 2014-03-05 | 公開日 | 2015-04-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | SQ109, a new drug lead for Chagas disease. Antimicrob.Agents Chemother., 59, 2015
|
|
8HFR
| NPC-trapped pre-60S particle | 分子名称: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | 著者 | Li, Z.Q, Chen, S.J, Sui, S.F. | 登録日 | 2022-11-12 | 公開日 | 2023-04-12 | 最終更新日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618, 2023
|
|
8HBN
| |
8WE6
| Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
|
|
8WEA
| Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2 Angstrom resolution | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
|
|
8WE9
| Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Fan, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
|
|
8WE8
| Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2023-09-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
|
|