8EUY
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![BU of 8euy by Molmil](/molmil-images/mine/8euy) | Ytm1 associated nascent 60S ribosome (-fkbp39) State 1A | 分子名称: | 60S ribosomal protein L13, 60S ribosomal protein L14, 60S ribosomal protein L15-A, ... | 著者 | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | 登録日 | 2022-10-19 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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8EUI
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![BU of 8eui by Molmil](/molmil-images/mine/8eui) | Ytm1 associated nascent 60S ribosome (-fkbp39) State 3 | 分子名称: | 60S ribosomal protein L10-A, 60S ribosomal protein L11-A, 60S ribosomal protein L13, ... | 著者 | Zhou, X, Bilokapic, S, Deshmukh, A.A, Halic, M. | 登録日 | 2022-10-18 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Chromatin localization of nucleophosmin organizes ribosome biogenesis. Mol.Cell, 82, 2022
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3ITF
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7YC9
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![BU of 7yc9 by Molmil](/molmil-images/mine/7yc9) | Co-crystal structure of BTK kinase domain with inhibitor | 分子名称: | (7~{S})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, Tyrosine-protein kinase BTK | 著者 | Zhou, X. | 登録日 | 2022-07-01 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J.Med.Chem., 66, 2023
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7DPT
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![BU of 7dpt by Molmil](/molmil-images/mine/7dpt) | Structural basis for ligand binding modes of CTP synthase | 分子名称: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | 登録日 | 2020-12-21 | 公開日 | 2021-09-15 | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | 主引用文献 | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DPW
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![BU of 7dpw by Molmil](/molmil-images/mine/7dpw) | Structural basis for ligand binding modes of CTP synthase | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | 登録日 | 2020-12-21 | 公開日 | 2021-09-15 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
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8CU6
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![BU of 8cu6 by Molmil](/molmil-images/mine/8cu6) | Crystal structure of A2AAR-StaR2-S277-bRIL in complex with a novel A2a antagonist, LJ-4517 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | 著者 | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | 登録日 | 2022-05-16 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor. J.Med.Chem., 65, 2022
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8CU7
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![BU of 8cu7 by Molmil](/molmil-images/mine/8cu7) | Crystal structure of A2AAR-StaR2-bRIL in complex with a novel A2a antagonist, LJ-4517 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | 著者 | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | 登録日 | 2022-05-16 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor. J.Med.Chem., 65, 2022
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2FA9
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![BU of 2fa9 by Molmil](/molmil-images/mine/2fa9) | The crystal structure of Sar1[H79G]-GDP provides insight into the coat-controlled GTP hydrolysis in the disassembly of COP II | 分子名称: | GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Rao, Y, Huang, M, Yuan, C, Bian, C, Hou, X. | 登録日 | 2005-12-07 | 公開日 | 2006-09-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP II Chin.J.Struct.Chem., 25, 2006
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7ESH
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![BU of 7esh by Molmil](/molmil-images/mine/7esh) | Crystal structure of amylosucrase from Calidithermus timidus | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, amylosucrase | 著者 | Tian, Y, Hou, X, Ni, D, Xu, W, Guang, C, Zhang, W, Rao, Y, Mu, W. | 登録日 | 2021-05-10 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structure-based interface engineering methodology in designing a thermostable amylose-forming transglucosylase J.Biol.Chem., 298, 2022
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1SZS
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![BU of 1szs by Molmil](/molmil-images/mine/1szs) | The structure of gamma-aminobutyrate aminotransferase mutant: I50Q | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ... | 著者 | Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Zhou, X, Fisher, A.J, Toney, M.D. | 登録日 | 2004-04-06 | 公開日 | 2005-03-01 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase. Biochemistry, 44, 2005
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1SZU
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![BU of 1szu by Molmil](/molmil-images/mine/1szu) | The structure of gamma-aminobutyrate aminotransferase mutant: V241A | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-aminobutyrate aminotransferase, ... | 著者 | Liu, W, Peterson, P.E, Langston, J.A, Jin, X, Zhou, X, Fisher, A.J, Toney, M.D. | 登録日 | 2004-04-06 | 公開日 | 2005-03-01 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coligamma-Aminobutyrate Aminotransferase. Biochemistry, 44, 2005
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6KTR
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![BU of 6ktr by Molmil](/molmil-images/mine/6ktr) | Crystal structure of fibroblast growth factor 19 in complex with Fab | 分子名称: | Fibroblast growth factor 19, G1A8-Fab-HC, G1A8-Fab-LC, ... | 著者 | Liu, H, Zheng, S, Hou, X, Liu, X, Lv, X, Li, Y, Li, W, Sui, J. | 登録日 | 2019-08-28 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.59775758 Å) | 主引用文献 | Novel Abs targeting the N-terminus of fibroblast growth factor 19 inhibit hepatocellular carcinoma growth without bile-acid-related side-effects. Cancer Sci., 111, 2020
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3ESW
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![BU of 3esw by Molmil](/molmil-images/mine/3esw) | Complex of yeast PNGase with GlcNAc2-IAc. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase, UV excision repair protein RAD23, ... | 著者 | Zhao, G, Zhou, X, Lennarz, W.J, Schindelin, H. | 登録日 | 2008-10-06 | 公開日 | 2008-11-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural and mutational studies on the importance of oligosaccharide binding for the activity of yeast PNGase. Glycobiology, 19, 2009
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4UIS
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![BU of 4uis by Molmil](/molmil-images/mine/4uis) | The cryoEM structure of human gamma-Secretase complex | 分子名称: | GAMMA-SECRETASE, LYSOZYME | 著者 | Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y. | 登録日 | 2015-04-03 | 公開日 | 2015-06-10 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structural Basis of Human Gamma-Secretase Assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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8UYJ
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![BU of 8uyj by Molmil](/molmil-images/mine/8uyj) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | 分子名称: | BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYL
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![BU of 8uyl by Molmil](/molmil-images/mine/8uyl) | MERS 5' proximal stem-loop 5, conformation 2 | 分子名称: | MERS 5' proximal stem-loop 5 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYM
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![BU of 8uym by Molmil](/molmil-images/mine/8uym) | MERS 5' proximal stem-loop 5, conformation 3 | 分子名称: | MERS 5' proximal stem-loop 5 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYK
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![BU of 8uyk by Molmil](/molmil-images/mine/8uyk) | MERS 5' proximal stem-loop 5, conformation 1 | 分子名称: | MERS 5' proximal stem-loop 5 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYG
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![BU of 8uyg by Molmil](/molmil-images/mine/8uyg) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 2 | 分子名称: | RNA (135-MER) | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYE
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![BU of 8uye by Molmil](/molmil-images/mine/8uye) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 1 | 分子名称: | BtCoV-HKU5 5' proximal stem-loop 5 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYP
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![BU of 8uyp by Molmil](/molmil-images/mine/8uyp) | SARS-CoV-1 5' proximal stem-loop 5 | 分子名称: | SARS-CoV-1 5' proximal stem-loop 5 | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-13 | 公開日 | 2023-12-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYS
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![BU of 8uys by Molmil](/molmil-images/mine/8uys) | SARS-CoV-2 5' proximal stem-loop 5 | 分子名称: | SARS-CoV-2 RNA SL5 domain. | 著者 | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | 登録日 | 2023-11-14 | 公開日 | 2023-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WUE
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8W4C
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![BU of 8w4c by Molmil](/molmil-images/mine/8w4c) | The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking | 分子名称: | PROGESTERONE, Sigma non-opioid intracellular receptor 1 | 著者 | Xiao, Y, Fu, C, Sun, Z, Zhou, X. | 登録日 | 2023-08-23 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.676 Å) | 主引用文献 | Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor. Nat Commun, 15, 2024
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