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4Q4J
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BU of 4q4j by Molmil
Structure of crosslinked TM287/288_S498C_S520C mutant
分子名称: ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288
著者Hohl, M, Schoeppe, J, Gruetter, M.G, Seeger, M.A.
登録日2014-04-14
公開日2014-07-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Q7K
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BU of 4q7k by Molmil
Structure of NBD287 of TM287/288
分子名称: ABC transporter
著者Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A.
登録日2014-04-25
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Biochemistry, 54, 2015
4Q7L
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BU of 4q7l by Molmil
Structure of NBD288 of TM287/288
分子名称: NICKEL (II) ION, Uncharacterized ABC transporter ATP-binding protein TM_0288
著者Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A.
登録日2014-04-25
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Biochemistry, 54, 2015
4Q4H
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TM287/288 in its apo state
分子名称: ABC transporter, Uncharacterized ABC transporter ATP-binding protein TM_0288
著者Hohl, M, Gruetter, M.G, Seeger, M.A.
登録日2014-04-14
公開日2014-07-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.527 Å)
主引用文献Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Q7M
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Structure of NBD288-Avi of TM287/288
分子名称: Uncharacterized ABC transporter ATP-binding protein TM_0288
著者Bukowska, M.A, Hohl, M, Gruetter, M.G, Seeger, M.A.
登録日2014-04-25
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.
Biochemistry, 54, 2015
4J7W
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E3_5 DARPin L86A mutant
分子名称: DARPin_E3_5_L86A
著者Seeger, M.A, Gruetter, M.G.
登録日2013-02-14
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity.
Protein Sci., 22, 2013
4J8Y
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E3_5 DARPin D77S mutant
分子名称: DARPin_E3_5_D77S
著者Seeger, M.A, Gruetter, M.G.
登録日2013-02-15
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity.
Protein Sci., 22, 2013
4JB8
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Caspase-7 in Complex with DARPin C7_16
分子名称: Caspase-7 subunit p11, Caspase-7 subunit p20, DARPin C7_16
著者Fluetsch, A, Seeger, M.A, Gruetter, M.G.
登録日2013-02-19
公開日2013-08-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity.
Protein Sci., 22, 2013
1TGJ
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BU of 1tgj by Molmil
HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE
分子名称: 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3
著者Mittl, P.R.E, Priestle, J.P, Gruetter, M.G.
登録日1996-07-09
公開日1997-01-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
4LSZ
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Caspase-7 in Complex with DARPin D7.18
分子名称: Caspase-7 subunit p10, Caspase-7 subunit p20, DARPin D7.18
著者Fluetsch, A, Lukarska, M, Gruetter, M.G.
登録日2013-07-23
公開日2014-07-02
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise.
Biochem.J., 461, 2014
1BX7
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HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.2 ANGSTROMS
分子名称: HIRUSTASIN, SULFATE ION
著者Uson, I, Sheldrick, G.M, De La Fortelle, E, Bricogne, G, Di Marco, S, Priestle, J.P, Gruetter, M.G, Mittl, P.R.E.
登録日1998-10-14
公開日1999-04-27
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors.
Structure Fold.Des., 7, 1999
1BX8
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HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.4 ANGSTROMS
分子名称: HIRUSTASIN, SULFATE ION
著者Uson, I, Sheldrick, G.M, De La Fortelle, E, Bricogne, G, Di Marco, S, Priestle, J.P, Gruetter, M.G, Mittl, P.R.E.
登録日1998-10-14
公開日1999-04-27
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors.
Structure Fold.Des., 7, 1999
3EO1
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BU of 3eo1 by Molmil
Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3
分子名称: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3
著者Gruetter, C, Gruetter, M.G.
登録日2008-09-26
公開日2008-12-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
3EO0
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BU of 3eo0 by Molmil
Structure of the Transforming Growth Factor-Beta Neutralizing Antibody GC-1008
分子名称: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, GLYCEROL
著者Gruetter, C, Gruetter, M.G.
登録日2008-09-26
公開日2008-12-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions
Proc.Natl.Acad.Sci.Usa, 105, 2008
3G7Y
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Crystal structure of oxidized Ost6L
分子名称: Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6
著者Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M.
登録日2009-02-11
公開日2009-06-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.215 Å)
主引用文献Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.
Proc.Natl.Acad.Sci.USA, 106, 2009
3GA4
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Crystal structure of Ost6L (photoreduced form)
分子名称: 1,2-ETHANEDIOL, Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6, TETRAETHYLENE GLYCOL
著者Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M.
登録日2009-02-16
公開日2009-06-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.
Proc.Natl.Acad.Sci.USA, 106, 2009
3G9B
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BU of 3g9b by Molmil
Crystal structure of reduced Ost6L
分子名称: Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6
著者Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M.
登録日2009-02-13
公開日2009-06-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.
Proc.Natl.Acad.Sci.USA, 106, 2009
154L
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BU of 154l by Molmil
THE REFINED STRUCTURES OF GOOSE LYSOZYME AND ITS COMPLEX WITH A BOUND TRISACCHARIDE SHOW THAT THE "GOOSE-TYPE LYSOZYMES LACK A CATALYTIC ASPARTATE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GOOSE LYSOZYME
著者Weaver, L.H, Gruetter, M.G, Matthews, B.W.
登録日1994-05-05
公開日1995-01-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" lysozymes lack a catalytic aspartate residue.
J.Mol.Biol., 245, 1995
1C94
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BU of 1c94 by Molmil
REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.
分子名称: RETRO-GCN4 LEUCINE ZIPPER
著者Mittl, P.R.E, Deillon, C.A, Sargent, D, Liu, N, Klauser, S, Thomas, R.M, Gutte, B, Gruetter, M.G.
登録日1999-07-30
公開日2000-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.
Proc.Natl.Acad.Sci.USA, 97, 2000
1CP3
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BU of 1cp3 by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE INHIBITOR ACE-DVAD-FMC
分子名称: ACETYL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE, APOPAIN
著者Mittl, P.R.E, Dimarco, S, Gruetter, M.G.
登録日1996-12-12
公開日1997-12-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.
J.Biol.Chem., 272, 1997
153L
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THE REFINED STRUCTURES OF GOOSE LYSOZYME AND ITS COMPLEX WITH A BOUND TRISACCHARIDE SHOW THAT THE "GOOSE-TYPE LYSOZYMES LACK A CATALYTIC ASPARTATE
分子名称: GOOSE LYSOZYME
著者Weaver, L.H, Gruetter, M.G, Matthews, B.W.
登録日1994-05-05
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" lysozymes lack a catalytic aspartate residue.
J.Mol.Biol., 245, 1995
2C2K
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BU of 2c2k by Molmil
Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.
分子名称: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-14-(4-ETHOXY-4-OXOBUTANOYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN -16-OIC ACID, ...
著者Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C.
登録日2005-09-29
公開日2006-09-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2C2M
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Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.
分子名称: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-[4-(BENZYLOXY)-4-OXOBUTANOYL]-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14 -PENTAAZAHEXADECAN-16-OIC ACID, ...
著者Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C.
登録日2005-09-29
公開日2006-09-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2C2O
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Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.
分子名称: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-14-{4-[BENZYL(METHYL) AMINO]-4-OXOBUTANOYL}-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ...
著者Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C.
登録日2005-09-29
公開日2006-09-20
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2C2Z
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Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor
分子名称: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL) -14-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL] -11-[(1R)-1-HYDROXYETHYL]-5-(2-METHYLPROPYL)-3,6,9,12-TETRAOXO -1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ...
著者Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Powers, J.C, Gruetter, M.G.
登録日2005-10-02
公開日2006-09-20
最終更新日2017-02-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006

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