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1LDP
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BU of 1ldp by Molmil
CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS I H-2LD, ...
著者Speir, J.A, Wilson, I.A.
登録日1998-03-15
公開日1998-06-17
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.
Immunity, 8, 1998
5JOR
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BU of 5jor by Molmil
Crystal structure of unbound anti-glycan antibody Fab14.22 at 2.2 A
分子名称: Fab 14.22 light chain, Fab14.22 heavy chain, GLYCEROL, ...
著者Sarkar, A, Irimia, A, Teyton, L, Wilson, I.A.
登録日2016-05-02
公開日2017-03-22
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2.206 Å)
主引用文献T cells control the generation of nanomolar-affinity anti-glycan antibodies.
J. Clin. Invest., 127, 2017
1TZG
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BU of 1tzg by Molmil
Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41
分子名称: Envelope polyprotein GP160, Fab 4E10, GLYCEROL
著者Cardoso, R.M.F, Zwick, M.B, Stanfield, R.L, Kunert, R, Binley, J.M, Katinger, H, Burton, D.R, Wilson, I.A.
登録日2004-07-09
公開日2005-03-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
Immunity, 22, 2005
1U9K
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BU of 1u9k by Molmil
Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76
分子名称: ZINC ION, triggering receptor expressed on myeloid cells 1
著者Kelker, M.S, Debler, E.W, Wilson, I.A.
登録日2004-08-09
公開日2004-12-14
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal Structure of Mouse Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.76A
J.Mol.Biol., 344, 2004
1U7D
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BU of 1u7d by Molmil
crystal structure of apo M. jannashii tyrosyl-tRNA synthetase
分子名称: Tyrosyl-tRNA synthetase
著者Zhang, Y, Wang, L, Schultz, P.G, Wilson, I.A.
登録日2004-08-03
公開日2005-05-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein Sci., 14, 2005
5JS9
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BU of 5js9 by Molmil
Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kong, L, Wilson, I.A.
登録日2016-05-07
公開日2016-07-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (6.918 Å)
主引用文献Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
1U21
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BU of 1u21 by Molmil
transthyretin with tethered inhibitor on one monomer.
分子名称: 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin
著者Wiseman, R.L, Johnson, S.M, Kelker, M.S, Foss, T, Wilson, I.A, Kelly, J.W.
登録日2004-07-16
公開日2005-06-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Kinetic stabilization of an oligomeric protein by a single ligand binding event
J.Am.Chem.Soc., 127, 2005
5JSA
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BU of 5jsa by Molmil
Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kong, L, Wilson, I.A.
登録日2016-05-07
公開日2016-07-13
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (6.308 Å)
主引用文献Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
1U7X
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BU of 1u7x by Molmil
crystal structure of a mutant M. jannashii tyrosyl-tRNA synthetase specific for O-methyl-tyrosine
分子名称: POTASSIUM ION, Tyrosyl-tRNA synthetase
著者Zhang, Y, Wang, L, Schultz, P.G, Wilson, I.A.
登録日2004-08-04
公開日2005-05-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein Sci., 14, 2005
3CN0
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BU of 3cn0 by Molmil
Human transthyretin (TTR) in complex with 3,5-Dimethyl-4-hydroxystilbene
分子名称: 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
3CFB
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BU of 3cfb by Molmil
High-resolution structure of blue fluorescent antibody EP2-19G2 in complex with stilbene hapten at 100K
分子名称: 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID, BLUE FLUORESCENT ANTIBODY EP2-19G2-IGG2B HEAVY CHAIN, BLUE FLUORESCENT ANTIBODY EP2-19G2-KAPPA LIGHT CHAIN, ...
著者Debler, E.W, Wilson, I.A.
登録日2008-03-03
公開日2008-03-18
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex.
Science, 319, 2008
3CN1
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BU of 3cn1 by Molmil
Human transthyretin (TTR) in complex with 3,5-Dibromo-4-hydroxystilbene
分子名称: 2,6-dibromo-4-[(E)-2-phenylethenyl]phenol, Transthyretin
著者Connelly, S, Wilson, I.A.
登録日2008-03-24
公開日2008-10-28
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
J.Med.Chem., 51, 2008
9AX2
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BU of 9ax2 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 2-(1-methyl-3-oxo-5-(2-phenylpropoxy)isoindolin-2-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate
分子名称: 2-{(1R)-1-methyl-3-oxo-5-[(2S)-2-phenylpropoxy]-1,3-dihydro-2H-isoindol-2-yl}ethyl {[(3M)-3-(1H-imidazol-4-yl)phenyl]methyl}carbamate, H9 Immunoglobulin Light Chain, PHOSPHATE ION
著者Lederberg, O.L, Yan, N.L, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
登録日2024-03-05
公開日2024-12-18
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
J.Med.Chem., 67, 2024
9AX3
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BU of 9ax3 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 4-(3-ethyl-3-phenylpyrrolidin-1-yl)-1,6-dimethylpyridin-2(1H)-one
分子名称: 4-[(3R)-3-ethyl-3-phenylpyrrolidin-1-yl]-1,6-dimethylpyridin-2(1H)-one, H9 Immunoglobulin Light Chain, PHOSPHATE ION
著者Lederberg, O.L, Yan, N.L, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
登録日2024-03-05
公開日2024-12-18
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
J.Med.Chem., 67, 2024
9AWY
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BU of 9awy by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 3-(2-(4-(3-ethyl-3-phenylpyrrolidin-1-yl)-6-methyl-2-oxopyridin-1(2H)-yl)ethyl)-8-(imidazo[1,5-a]pyrazin-8-yl)-1,3,8-triazaspiro[4.5]decan-2-one
分子名称: 3-(2-{4-[(3R)-3-ethyl-3-phenylpyrrolidin-1-yl]-6-methyl-2-oxopyridin-1(2H)-yl}ethyl)-8-[(4R)-imidazo[1,5-a]pyrazin-8-yl]-1,3,8-triazaspiro[4.5]decan-2-one, H9 Immunoglobulin Light Chain, PHOSPHATE ION
著者Lederberg, O.L, Kelly, J.W, Yan, N.L, Wilson, I.A, Stanfield, R.L.
登録日2024-03-05
公開日2024-12-18
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
J.Med.Chem., 67, 2024
9AWX
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BU of 9awx by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 1-(1-(imidazo[1,5-a]pyrazin-8-yl)azetidin-3-yl)-3-(2-(6-methyl-4-(3-methyl-3-phenylpyrrolidin-1-yl)-2-oxopyridin-1(2H)-yl)ethyl)urea
分子名称: H9 Immunoglobulin Light Chain, N-{1-[(4R)-imidazo[1,5-a]pyrazin-8-yl]azetidin-3-yl}-N'-(2-{6-methyl-4-[(3R)-3-methyl-3-phenylpyrrolidin-1-yl]-2-oxopyridin-1(2H)-yl}ethyl)urea, PHOSPHATE ION
著者Lederberg, O.L, Yan, N.L, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
登録日2024-03-05
公開日2024-12-18
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
J.Med.Chem., 67, 2024
9AX1
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BU of 9ax1 by Molmil
Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 2-(6-methyl-2-oxo-4-(2-phenylpropoxy)pyridin-1(2H)-yl)ethyl (3-(1H-imidazol-4-yl)benzyl)carbamate
分子名称: 2-{6-methyl-2-oxo-4-[(2S)-2-phenylpropoxy]pyridin-1(2H)-yl}ethyl {[(3P)-3-(1H-imidazol-4-yl)phenyl]methyl}carbamate, H9 Immunoglobulin Light Chain, PHOSPHATE ION
著者Lederberg, O.L, Yan, N.L, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
登録日2024-03-05
公開日2024-12-18
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.
J.Med.Chem., 67, 2024
5KZC
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BU of 5kzc by Molmil
Crystal structure of an HIV-1 gp120 engineered outer domain with a Man9 glycan at position N276, in complex with broadly neutralizing antibody VRC01
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Engineered outer domain of gp120, VRC01 Fab heavy chain, ...
著者Julien, J.-P, Jardine, J.G, Diwanji, D, Schief, W.R, Wilson, I.A.
登録日2016-07-24
公開日2016-08-10
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Plos Pathog., 12, 2016
6FYT
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BU of 6fyt by Molmil
Structure of H1 (A/solomon Islands/3/06) Influenza Hemagglutinin in complex with SD38
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYW
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BU of 6fyw by Molmil
Structure of B/Brisbane/60/2008 Influenza Hemagglutinin in complex with SD83
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2024-12-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin
Science, 362, 2018
6FYU
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BU of 6fyu by Molmil
Structure of H7(A/Shanghai/2/2013) Influenza Hemagglutinin in complex SD36
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.643 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
6FYS
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BU of 6fys by Molmil
Structure of single domain antibody SD83
分子名称: 1,2-ETHANEDIOL, Single domain antibody SD83
著者Laursen, N.S, Wilson, I.A.
登録日2018-03-12
公開日2018-11-07
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
3GAR
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BU of 3gar by Molmil
A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
分子名称: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
著者Su, Y, Yamashita, M.M, Greasley, S.E, Mullen, C.A, Shim, J.H, Jennings, P.A, Benkovic, S.J, Wilson, I.A.
登録日1998-05-13
公開日1998-08-12
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
J.Mol.Biol., 281, 1998
7U2E
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BU of 7u2e by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADI-55688
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-55688 heavy chain, ADI-55688 light chain, ...
著者Yuan, M, Zhu, X, Wilson, I.A.
登録日2022-02-23
公開日2022-05-04
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献A broad and potent neutralization epitope in SARS-related coronaviruses.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U2D
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BU of 7u2d by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody ADG20
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADG20 heavy chain, ADG20 light chain, ...
著者Zhu, X, Yuan, M, Wilson, I.A.
登録日2022-02-23
公開日2022-05-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献A broad and potent neutralization epitope in SARS-related coronaviruses.
Proc.Natl.Acad.Sci.USA, 119, 2022

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