7N8V
 
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3NQS
 | | Crystal Structure of Inducible Nitric Oxide Synthase with N-Nitrosated-pterin | | 分子名称: | 1,2-ETHANEDIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE, ... | | 著者 | Rosenfeld, R.J, Getzoff, E.D, Tainer, J.A. | | 登録日 | 2010-06-29 | | 公開日 | 2010-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
J.Biol.Chem., 285, 2010
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2SSP
 | | LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA | | 分子名称: | DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*TP*(AAB)P*AP*TP*CP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE) | | 著者 | Parikh, S.S, Mol, C.D, Slupphaug, G, Bharati, S, Krokan, H.E, Tainer, J.A. | | 登録日 | 1999-04-28 | | 公開日 | 1999-05-06 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO J., 17, 1998
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8D3G
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8D3O
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8D3J
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8D3H
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8D3E
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8D3I
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8D3N
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8D3K
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5UM9
 | | Flap endonuclease 1 (FEN1) D86N with 5'-flap substrate DNA and Sm3+ | | 分子名称: | DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3'), DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*CP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ... | | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | | 登録日 | 2017-01-26 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
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3HUF
 | | Structure of the S. pombe Nbs1-Ctp1 complex | | 分子名称: | DNA repair and telomere maintenance protein nbs1, Double-strand break repair protein ctp1, THIOCYANATE ION | | 著者 | Williams, R.S, Guenther, G, Tainer, J.A. | | 登録日 | 2009-06-13 | | 公開日 | 2009-10-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell(Cambridge,Mass.), 139, 2009
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3HVC
 | | Crystal structure of human p38alpha MAP kinase | | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, Mitogen-activated protein kinase 14 | | 著者 | Perry, J.J, Tainer, J.A. | | 登録日 | 2009-06-15 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
J.Mol.Biol., 391, 2009
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3HRV
 | | Crystal structure of TcpA, a Type IV pilin from Vibrio cholerae El Tor biotype | | 分子名称: | GLYCEROL, SULFATE ION, Toxin coregulated pilin | | 著者 | Craig, L, Arvai, A.S, Tainer, J.A. | | 登録日 | 2009-06-09 | | 公開日 | 2010-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Vibrio cholerae El Tor TcpA crystal structure and mechanism for pilus-mediated microcolony formation.
Mol.Microbiol., 77, 2010
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3HUE
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3L41
 | | Crystal Structure of S. pombe Brc1 BRCT5-BRCT6 domains in complex with phosphorylated H2A | | 分子名称: | BRCT-containing protein 1, phosphorylated H2A tail | | 著者 | Williams, R.S, Williams, J.S, Guenther, G, Tainer, J.A. | | 登録日 | 2009-12-18 | | 公開日 | 2010-02-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | gammaH2A binds Brc1 to maintain genome integrity during S-phase.
Embo J., 29, 2010
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3L2P
 | | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States | | 分子名称: | 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... | | 著者 | Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. | | 登録日 | 2009-12-15 | | 公開日 | 2010-07-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Biochemistry, 49, 2010
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3L40
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1QOM
 | | MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER (DELTA 65) WITH SWAPPED N-TERMINAL HOOK | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Crane, B.R, Rosenfeld, R.A, Arvai, A.S, Tainer, J.A, Stuehr, D.J, Getzoff, E.D. | | 登録日 | 1999-11-15 | | 公開日 | 1999-12-15 | | 最終更新日 | 2019-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | N-Terminal Domain Swapping and Metal Ion Binding in Nitric Oxide Synthase Dimerization
Embo J., 18, 1999
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6VBH
 | | Human XPG endonuclease catalytic domain | | 分子名称: | DNA repair protein complementing XP-G cells,Flap endonuclease 1, SULFATE ION | | 著者 | Tsutakawa, S.E, Arvai, A.S, Tainer, J.A. | | 登録日 | 2019-12-18 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | | 主引用文献 | Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VBA
 | | Structure of human Uracil DNA Glycosylase (UDG) bound to Aurintricarboxylic acid (ATA) | | 分子名称: | 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid), Uracil-DNA glycosylase | | 著者 | Moiani, D, Arvai, A.S, Tainer, J.A. | | 登録日 | 2019-12-18 | | 公開日 | 2021-03-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Prog.Biophys.Mol.Biol., 163, 2021
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6WH1
 | | Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains | | 分子名称: | DNA ligase 3 alpha, X-ray repair cross complementing protein 1 variant | | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | | 登録日 | 2020-04-07 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
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6WH2
 | | Structure of the C-terminal BRCT domain of human XRCC1 | | 分子名称: | X-ray repair cross complementing protein 1 variant | | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | | 登録日 | 2020-04-07 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.414 Å) | | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
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2ABK
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