5WAI
 
 | | Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex | | 分子名称: | Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... | | 著者 | Chen, S, Jiao, L, Liu, X. | | 登録日 | 2017-06-26 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
Mol. Cell, 69, 2018
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2AHD
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4MNV
 | | Crystal structure of bicyclic peptide UK729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (uPA) | | 分子名称: | 1,3,5-tris(bromomethyl)benzene, ACETATE ION, GLYCEROL, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2013-09-11 | | 公開日 | 2014-02-05 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4MNW
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK749 | | 分子名称: | 1,3,5-tris(bromomethyl)benzene, ACETATE ION, GLYCEROL, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2013-09-11 | | 公開日 | 2014-02-05 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4MNY
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK903 | | 分子名称: | ACETATE ION, GLYCEROL, N,N',N''-benzene-1,3,5-triyltris(2-bromoacetamide), ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2013-09-11 | | 公開日 | 2014-02-05 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
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4A0P
 | | Crystal structure of LRP6P3E3P4E4 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chen, S, Malinauskas, T, Aricescu, A.R, Siebold, C, Jones, E.Y. | | 登録日 | 2011-09-11 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Functional Studies of Lrp6 Ectodomain Reveal a Platform for Wnt Signaling.
Dev.Cell, 21, 2011
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4OS5
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4OS1
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK601 (bicyclic 1) | | 分子名称: | ACETATE ION, SULFATE ION, Urokinase-type plasminogen activator, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2014-02-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2021-06-02 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
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4OS4
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK603 (bicyclic 1) | | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2014-02-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2021-06-02 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
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4OS6
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK604 (bicyclic 2) | | 分子名称: | ACETATE ION, SULFATE ION, Urokinase-type plasminogen activator, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2014-02-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2021-06-02 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
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4OS2
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK602 (bicyclic 1) | | 分子名称: | ACETATE ION, SULFATE ION, Urokinase-type plasminogen activator, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2014-02-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2021-06-02 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
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4OS7
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK607 (bicyclic) | | 分子名称: | ACETATE ION, GLYCEROL, SULFATE ION, ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2014-02-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2021-06-02 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Nat Chem, 6, 2014
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6J20
 | | Crystal structure of the human NK1 substance P receptor | | 分子名称: | 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, Substance-P receptor,Endolysin | | 著者 | Chen, S, Lu, M, Zhang, H, Wu, B, Zhao, Q. | | 登録日 | 2018-12-30 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
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6J21
 | | Crystal structure of the human NK1 substance P receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, Substance-P receptor,Endolysin | | 著者 | Chen, S, Lu, M, Zhang, H, Wu, B, Zhao, Q. | | 登録日 | 2018-12-30 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
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7Y26
 | | Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex | | 分子名称: | Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7Y27
 | | Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7Y24
 | | Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7DHY
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7DHZ
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6M3M
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1HQ7
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6LFD
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6LF4
 | | Crystal structure of VMB-1 bound to hydrolyzed meropenem | | 分子名称: | (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy l)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, VMB-1 metallo-beta-lactamase, ZINC ION | | 著者 | Cheng, Q, Chen, S. | | 登録日 | 2019-11-28 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Crystal structure of VMB-1 bound to hydrolyzed meropenem
To Be Published
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7LT3
 | | NHEJ Long-range synaptic complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | | 著者 | He, Y, Chen, S. | | 登録日 | 2021-02-18 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
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7LSY
 | | NHEJ Short-range synaptic complex | | 分子名称: | DNA (26-MER), DNA (5'-D(P*CP*AP*AP*TP*GP*AP*AP*AP*CP*GP*GP*AP*AP*CP*AP*GP*TP*CP*AP*G)-3'), DNA (5'-D(P*GP*TP*TP*CP*TP*TP*AP*GP*TP*AP*TP*AP*TP*A)-3'), ... | | 著者 | He, Y, Chen, S. | | 登録日 | 2021-02-18 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | | 主引用文献 | Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature, 593, 2021
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