4RUP
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![BU of 4rup by Molmil](/molmil-images/mine/4rup) | Crystal structure of zVDR L337H mutant-Gemini72 complex | 分子名称: | (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | 著者 | Huet, T, Moras, D, Rochel, N. | 登録日 | 2014-11-21 | 公開日 | 2015-10-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10, 2015
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1VEE
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![BU of 1vee by Molmil](/molmil-images/mine/1vee) | NMR structure of the hypothetical rhodanese domain At4g01050 from Arabidopsis thaliana | 分子名称: | proline-rich protein family | 著者 | Pantoja-Uceda, D, Lopez-Mendez, B, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Seki, M, Shinozaki, K, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-30 | 公開日 | 2005-01-25 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the rhodanese homology domain At4g01050(175-295) from Arabidopsis thaliana Protein Sci., 14, 2005
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4RW3
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![BU of 4rw3 by Molmil](/molmil-images/mine/4rw3) | Structural insights into substrate binding of brown spider venom class II phospholipases D | 分子名称: | D-MYO-INOSITOL-1-PHOSPHATE, DECANOIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Coronado, M.A, Ullah, A, da Silva, L.S, Chaves-Moreira, D, Vuitika, L, Chaim, O.M, Veiga, S.S, Chahine, J, Murakami, M.T, Arni, R.K. | 登録日 | 2014-12-01 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D. Curr Protein Pept Sci, 16, 2015
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4TQF
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![BU of 4tqf by Molmil](/molmil-images/mine/4tqf) | Crystal Structure of the C-terminal domain of IFRS bound with 2-(5-bromothienyl)-L-Ala and ATP | 分子名称: | 1,2-ETHANEDIOL, 3-(5-bromothiophen-2-yl)-L-alanine, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Nakamura, A, O'Donoghue, P, Soll, D. | 登録日 | 2014-06-11 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7143 Å) | 主引用文献 | Polyspecific pyrrolysyl-tRNA synthetases from directed evolution. Proc.Natl.Acad.Sci.USA, 111, 2014
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4RW5
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![BU of 4rw5 by Molmil](/molmil-images/mine/4rw5) | Structural insights into substrate binding of brown spider venom class II phospholipases D | 分子名称: | GLYCEROL, MAGNESIUM ION, N-TRIDECANOIC ACID, ... | 著者 | Coronado, M.A, Ullah, A, da Silva, L.S, Chaves-Moreira, D, Vuitika, L, Chaim, O.M, Veiga, S.S, Chahine, J, Murakami, M.T, Arni, R.K. | 登録日 | 2014-12-01 | 公開日 | 2015-06-03 | 最終更新日 | 2015-12-16 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structural Insights into Substrate Binding of Brown Spider Venom Class II Phospholipases D. Curr Protein Pept Sci, 16, 2015
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4RML
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![BU of 4rml by Molmil](/molmil-images/mine/4rml) | Crystal structure of the Olfactomedin domain of latrophilin 3 in C2221 crystal form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Latrophilin-3, MAGNESIUM ION | 著者 | Ranaivoson, F.M, Liu, Q, Martini, F, Bergami, F, Von daake, S, Li, S, Demeler, B, Hendrickson, W.A, Comoletti, D. | 登録日 | 2014-10-21 | 公開日 | 2015-08-19 | 最終更新日 | 2015-10-07 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Structure, 23, 2015
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1VJ4
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![BU of 1vj4 by Molmil](/molmil-images/mine/1vj4) | SEQUENCE-DEPENDENT CONFORMATION OF AN A-DNA DOUBLE HELIX: THE CRYSTAL STRUCTURE OF THE OCTAMER D(G-G-T-A-T-A-C-C) | 分子名称: | 5'-D(*GP*GP*TP*AP*TP*AP*CP*C)-3' | 著者 | Shakked, Z, Rabinovich, D, Kennard, O, Cruse, W.B, Salisbury, S.A, Viswamitra, M.A. | 登録日 | 1989-01-11 | 公開日 | 1989-01-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Sequence-dependent conformation of an A-DNA double helix: The crystal structure of the octamer d(G-G-T-A-T-A-C-C) J.Mol.Biol., 166, 1983
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1VDY
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![BU of 1vdy by Molmil](/molmil-images/mine/1vdy) | NMR Structure of the hypothetical ENTH-VHS domain At3g16270 from Arabidopsis thaliana | 分子名称: | hypothetical protein (RAFL09-17-B18) | 著者 | Lopez-Mendez, B, Pantoja-Uceda, D, Tomizawa, T, Koshiba, S, Kigawa, T, Shirouzu, M, Terada, T, Inoue, M, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Seki, M, Shinozaki, K, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2004-03-25 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the hypothetical ENTH-VHS domain AT3G16270 from arabidopsis thaliana To be Published
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1W1D
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![BU of 1w1d by Molmil](/molmil-images/mine/1w1d) | Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate | 分子名称: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, GOLD ION, ... | 著者 | Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | 登録日 | 2004-06-21 | 公開日 | 2004-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates Embo J., 23, 2004
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3QCQ
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![BU of 3qcq by Molmil](/molmil-images/mine/3qcq) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-(3-Amino-1H-indazol-6-yl)-N4-ethyl-2,4-pyrimidinediamine | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-(3-amino-2H-indazol-6-yl)-N~4~-ethylpyrimidine-2,4-diamine, GLYCEROL, ... | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | 登録日 | 2011-01-17 | 公開日 | 2011-03-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3QCX
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![BU of 3qcx by Molmil](/molmil-images/mine/3qcx) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-{2-Amino-6-[(3R)-3-methyl-4-morpholinyl]-4-pyrimidinyl}-1H-indazol-3-amine | 分子名称: | 3-phosphoinositide-dependent protein kinase 1, 6-{2-amino-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}-2H-indazol-3-amine, GLYCEROL, ... | 著者 | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | 登録日 | 2011-01-17 | 公開日 | 2011-03-09 | 最終更新日 | 2011-11-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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5LO1
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![BU of 5lo1 by Molmil](/molmil-images/mine/5lo1) | HSP90 WITH indazole derivative | 分子名称: | 1-[2-Amino-4-(1,3-dihydro-isoindole-2-carbonyl)-quinazolin-6-yl]-cyclobutanecarboxylic acid ethylamide, Heat shock protein HSP 90-alpha | 著者 | Graedler, U, Amaral, M, Schuetz, D. | 登録日 | 2016-08-08 | 公開日 | 2017-11-29 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61, 2018
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2MBX
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![BU of 2mbx by Molmil](/molmil-images/mine/2mbx) | Structure, dynamics and stability of allergen cod parvalbumin Gad m 1 by solution and high-pressure NMR. | 分子名称: | CALCIUM ION, Parvalbumin beta | 著者 | Moraes, A.H, Ackerbauer, D, Bublin, M, Ferreira, F, Almeida, F.C.L, Breiteneder, H, Valente, A. | 登録日 | 2013-08-07 | 公開日 | 2014-08-20 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution and high-pressure NMR studies of the structure, dynamics, and stability of the cross-reactive allergenic cod parvalbumin Gad m 1. Proteins, 82, 2014
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7CZ5
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![BU of 7cz5 by Molmil](/molmil-images/mine/7cz5) | Cryo-EM structure of the human growth hormone-releasing hormone receptor-Gs protein complex | 分子名称: | CHOLESTEROL, Growth hormone-releasing hormone receptor,growth hormone-releasing hormone receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhou, F, Zhang, H, Cong, Z, Zhao, L, Zhou, Q, Mao, C, Cheng, X, Shen, D, Cai, X, Ma, C, Wang, Y, Dai, A, Zhou, Y, Sun, W, Zhao, F, Zhao, S, Jiang, H, Jiang, Y, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2020-09-07 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural basis for activation of the growth hormone-releasing hormone receptor. Nat Commun, 11, 2020
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7D68
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![BU of 7d68 by Molmil](/molmil-images/mine/7d68) | Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex | 分子名称: | Glucagon-like peptide 2 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, W, Chen, L, Zhou, Q, Zhao, L, Zhang, H, Cong, Z, Shen, D, Zhao, F, Zhou, F, Cai, X, Chen, Y, Zhou, Y, Gadgaard, S, van der Velden, W.J, Zhao, S, Jiang, Y, Rosenkilde, M.M, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2020-09-29 | 公開日 | 2020-12-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Res., 30, 2020
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4CZV
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![BU of 4czv by Molmil](/molmil-images/mine/4czv) | Structure of the Neurospora crassa Pan2 WD40 domain | 分子名称: | CHLORIDE ION, GLYCEROL, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2 | 著者 | Peter, D, Jonas, S, Izaurralde, E, Weichenrieder, O. | 登録日 | 2014-04-22 | 公開日 | 2014-06-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay. Nat.Struct.Mol.Biol., 21, 2014
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5LNY
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![BU of 5lny by Molmil](/molmil-images/mine/5lny) | HSP90 WITH indazole derivative | 分子名称: | 6-Hydroxy-3-(piperidine-1-carbonyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide, Heat shock protein HSP 90-alpha | 著者 | Graedler, U, Amaral, M, Schuetz, D. | 登録日 | 2016-08-08 | 公開日 | 2017-11-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61, 2018
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4CSV
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![BU of 4csv by Molmil](/molmil-images/mine/4csv) | Tyrosine kinase AS - a common ancestor of Src and Abl bound to Gleevec | 分子名称: | 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, SRC-ABL TYROSINE KINASE ANCESTOR | 著者 | Kutter, S, Wilson, C, Cruz, L, Agafonov, R.V, Hoemberger, M.S, Zorba, A, Kern, D. | 登録日 | 2014-03-10 | 公開日 | 2015-03-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism. Science, 347, 2015
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5LDD
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![BU of 5ldd by Molmil](/molmil-images/mine/5ldd) | |
4G76
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5MAU
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![BU of 5mau by Molmil](/molmil-images/mine/5mau) | Crystal structure of dimeric chlorite dismutase from Cyanothece sp. PCC7425 (pH 6.5) | 分子名称: | Chlorite dismutase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Puehringer, D, Schaffner, I, Mlynek, G, Obinger, C, Djinovic-Carugo, K. | 登録日 | 2016-11-04 | 公開日 | 2017-12-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Molecular Mechanism of Enzymatic Chlorite Detoxification: Insights from Structural and Kinetic Studies. ACS Catal, 7, 2017
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5ME0
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![BU of 5me0 by Molmil](/molmil-images/mine/5me0) | Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112 | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S. | 登録日 | 2016-11-14 | 公開日 | 2017-01-11 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | 主引用文献 | Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways. Nucleic Acids Res., 45, 2017
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4M5T
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![BU of 4m5t by Molmil](/molmil-images/mine/4m5t) | Disulfide trapped human alphaB crystallin core domain in complex with C-terminal peptide | 分子名称: | Alpha-crystallin B chain, SULFATE ION | 著者 | Laganowsky, A, Cascio, D, Hochberg, G, Sawaya, M.R, Benesch, J.L.P, Robinson, C.V, Eisenberg, D. | 登録日 | 2013-08-08 | 公開日 | 2014-04-09 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity. Proc.Natl.Acad.Sci.USA, 111, 2014
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5MAO
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5MHP
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![BU of 5mhp by Molmil](/molmil-images/mine/5mhp) | Novel Imidazo[1,2-a]pyridine Derivatives with Potent Autotaxin/ENPP2 Inhibitor Activity | 分子名称: | 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Fleury, D, Mueller, I, Lamers, M, Triballeau, N, Mollat, P, Vercheval, L. | 登録日 | 2016-11-25 | 公開日 | 2017-08-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. J. Med. Chem., 60, 2017
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