4CSV

Tyrosine kinase AS - a common ancestor of Src and Abl bound to Gleevec

Summary for 4CSV

Entry DOI	10.2210/pdb4csv/pdb
Descriptor	SRC-ABL TYROSINE KINASE ANCESTOR, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
Functional Keywords	transferase, dfg
Biological source	SYNTHETIC CONSTRUCT
Total number of polymer chains	1
Total formula weight	31750.13
Authors	Kutter, S.,Wilson, C.,Cruz, L.,Agafonov, R.V.,Hoemberger, M.S.,Zorba, A.,Kern, D. (deposition date: 2014-03-10, release date: 2015-03-04, Last modification date: 2023-12-20)
Primary citation	Wilson, C.,Agafonov, R.V.,Hoemberger, M.,Kutter, S.,Zorba, A.,Halpin, J.,Buosi, V.,Otten, R.,Waterman, D.,Theobald, D.L.,Kern, D. Kinase Dynamics. Using Ancient Protein Kinases to Unravel a Modern Cancer Drug'S Mechanism. Science, 347:882-, 2015 Cited by PubMed: 25700521 DOI: 10.1126/SCIENCE.AAA1823 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation