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7SHY
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BU of 7shy by Molmil
IgE-Fc in complex with omalizumab scFv
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, IgE Fc, ...
著者Pennington, L.F, Jardetzky, T.J, Kleinboelting, S.
登録日2021-10-11
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.
Nat Commun, 12, 2021
7SI0
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BU of 7si0 by Molmil
IgE-Fc in complex with 813
分子名称: 813 Variable fragment Heavy chain, 813 Variable fragment Light chain, IgE Fc, ...
著者Pennington, L.F, Jardetzky, T.J, Kleinboelting, S.
登録日2021-10-12
公開日2021-12-15
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.
Nat Commun, 12, 2021
7SHT
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BU of 7sht by Molmil
Structure of a partially disrupted IgE high affinity receptor complex bound to an omalizumab variant
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, ...
著者Pennington, L.F, Jardetzky, T.S.
登録日2021-10-11
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (7.29 Å)
主引用文献Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.
Nat Commun, 12, 2021
8EWG
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BU of 8ewg by Molmil
Cryo-EM structure of a riboendonclease
分子名称: CRISPR-associated endonuclease Cas9, RNA (56-MER)
著者Li, Z, Wang, F.
登録日2022-10-23
公開日2023-08-30
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola.
J.Mol.Biol., 435, 2023
5TSA
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BU of 5tsa by Molmil
Crystal structure of the Zrt-/Irt-like protein from Bordetella bronchiseptica with bound Zn2+
分子名称: CADMIUM ION, Membrane protein, ZINC ION
著者Zhang, T, Fellner, M, Sui, D, Liu, J, Hu, J.
登録日2016-10-28
公開日2017-09-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.
Sci Adv, 3, 2017
5TSB
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BU of 5tsb by Molmil
Crystal structure of the Zrt-/Irt-like protein from Bordetella bronchiseptica with bound Cd2+
分子名称: CADMIUM ION, Membrane protein
著者Zhang, T, Fellner, M, Sui, D, Liu, J, Hu, J.
登録日2016-10-28
公開日2017-09-20
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.
Sci Adv, 3, 2017
7MTQ
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BU of 7mtq by Molmil
CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495
分子名称: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2
著者Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
登録日2021-05-13
公開日2021-07-07
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
7MTR
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BU of 7mtr by Molmil
CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ...
著者Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
登録日2021-05-13
公開日2021-07-07
最終更新日2021-09-08
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
7MTS
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BU of 7mts by Molmil
CryoEM Structure of mGlu2 - Gi Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ...
著者Seven, A.B, Barros-Alvarez, X, Skiniotis, G.
登録日2021-05-13
公開日2021-07-07
最終更新日2021-07-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献G-protein activation by a metabotropic glutamate receptor.
Nature, 595, 2021
8HAF
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BU of 8haf by Molmil
PTHrP-PTH1R-Gs complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, L, Xu, H.E, Yuan, Q.
登録日2022-10-26
公開日2022-12-21
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
Acta Pharmacol.Sin., 44, 2023
8HA0
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BU of 8ha0 by Molmil
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, L, Xu, H.E, Yuan, Q.
登録日2022-10-26
公開日2022-12-21
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.62 Å)
主引用文献Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
Acta Pharmacol.Sin., 44, 2023
8HAO
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BU of 8hao by Molmil
Human parathyroid hormone receptor-1 dimer
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha, ...
著者Zhao, L, Xu, H.E, Yuan, Q.
登録日2022-10-26
公開日2022-12-21
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3.76 Å)
主引用文献Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
Acta Pharmacol.Sin., 44, 2023
6ULJ
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BU of 6ulj by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-08
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00045
To Be Published
5XP5
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BU of 5xp5 by Molmil
C-Src in complex with ATP-Chf
分子名称: MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid
著者Duan, Y, Guo, M, Dai, S, Chen, L, Chen, Y.
登録日2017-06-01
公開日2018-02-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
8H4U
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BU of 8h4u by Molmil
Cryo-EM structure of a riboendonuclease
分子名称: CRISPR-associated endonuclease Cas9
著者Li, Z, Wang, F.
登録日2022-10-11
公開日2023-08-30
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola.
J.Mol.Biol., 435, 2023
8H41
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BU of 8h41 by Molmil
Crystal structure of a decarboxylase from Trichosporon moniliiforme in complex with o-nitrophenol
分子名称: MAGNESIUM ION, O-NITROPHENOL, Salicylate decarboxylase
著者Gao, J, Zhao, Y.P, Li, Q, Liu, W.D, Sheng, X.
登録日2022-10-09
公開日2023-08-16
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase
Catalysts, 12, 2022
5XKD
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BU of 5xkd by Molmil
Crystal structure of dibenzothiophene sulfone monooxygenase BdsA in complex with FMN at 2.4 angstrom
分子名称: Dibenzothiophene desulfurization enzyme A, FLAVIN MONONUCLEOTIDE
著者Gu, L, Su, T, Liu, S, Su, J.
登録日2017-05-07
公開日2018-05-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.393 Å)
主引用文献Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the "4S" Desulfurization Pathway.
Front Microbiol, 9, 2018
6UK6
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BU of 6uk6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00018
分子名称: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-04
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00018
To Be Published
6UKB
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BU of 6ukb by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-04
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
6UJM
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BU of 6ujm by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00013
分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-03
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00013
To Be Published
6ULA
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BU of 6ula by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-07
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00030
To Be Published
7N9T
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BU of 7n9t by Molmil
CryoEM structure of SARS-CoV-2 Spike in complex with Nb17
分子名称: Nanobody Nb17, Spike glycoprotein
著者Huang, W, Taylor, D.
登録日2021-06-18
公開日2021-08-11
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
5XKC
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BU of 5xkc by Molmil
Crystal structure of dibenzothiophene sulfone monooxygenase BdsA at 2.2 angstrome
分子名称: Dibenzothiophene desulfurization enzyme A
著者Gu, L, Su, T, Liu, S, Su, J.
登録日2017-05-07
公開日2018-05-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.209 Å)
主引用文献Structural and Biochemical Characterization of BdsA fromBacillus subtilisWU-S2B, a Key Enzyme in the "4S" Desulfurization Pathway.
Front Microbiol, 9, 2018
5XP7
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BU of 5xp7 by Molmil
C-Src in complex with ATP-CHCl
分子名称: GLYCEROL, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, ...
著者Guo, M, Dai, S, Duan, Y, Chen, L, Chen, Y.
登録日2017-06-01
公開日2017-09-06
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.012 Å)
主引用文献Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
6UL9
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BU of 6ul9 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00023
分子名称: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q.Q, Cerione, R.A.
登録日2019-10-07
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published

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